One pot synthesis of some new 2-hydrazino-[1,3,4]thiadiazepino[7,6-b]quinolines under microwave irradiation conditions

Abstract

An efficient and convenient procedure has been developed for the synthesis of 2-hydrazino- [1,3,4]thiadiazepino [7,6-b]quinolines (2a-h) in good yields. They have been achieved by the reaction between corresponding 2-chloro-3-formyl-quinoline and carbidimide in specially desighned microwave oven for organic synthesis in unsealed borosil vessel in presence of pTsOH and dimethylformamide. The structure of new compounds has been evaluated on the basis of analytical, IR, 1 H NMR and mass spectral data.

Easy preparation, characterization and reactions of new 8‐chloro‐7‐formyl‐4‐oxo‐2‐phenyl‐4H‐pyrimido[1,2‐a]pyrimidine‐3‐carbonitrile

“…Then, reactivity of pyrimidopyrimidine 3 toward binucleophiles was performed 26 . Thus, cyclocondensation of compound 3 with thiocarbohyrazide and/or hydrazine carbodithioic acid afforded fused pyrimidopyrimidothiadiazepine derivatives 10 and 11 , respectively (Scheme 5).…”