One-pot synthesis of ZnO nanobelt-like structures in hyaluronan hydrogels for wound dressing applications

Rao, Kummara Madhusudana; Suneetha, Maduru; Zo, Sunmi; Duck, Kim Hyun; Han, Sung Soo

doi:10.1016/j.carbpol.2019.115124

Cited by 65 publications

(36 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A strain sweep test was first performed on all hydrogels in order to establish their linear viscoelastic domain and to compare the storage modulus values ( G ′) of the different formulations. As shown in Figure , the elastic modulus ( G ′) of the PEtOx-EI-Se 2 hydrogel with different Se-containing and swelling rates was higher than the loss modulus ( G ′′) at any tested strain and frequency, confirming the cross-linked structure of the samples and indicating that all evaluated hydrogels exhibit predominantly elastic behaviors . In the “as-prepared” state, the G ′ of the 2 mol % Se-containing is limited to around 5 kPa, while the 4 mol % Se-containing hydrogel exhibits a G ′ close to 17 kPa, which is in accordance with the higher theoretical cross-link density of the latter.…”

Section: Results and Discussionsupporting

confidence: 72%

On-Demand Dissoluble Diselenide-Containing Hydrogel

Imbernon

et al. 2020

Biomacromolecules

View full text Add to dashboard Cite

On-demand dissolution of hydrogels is being increasingly studied for their potential use in burn wound dressing applications. Herein, a dynamic diselenide-containing hydrogel is developed through a very simple one-pot and two-step process starting from the selenol functionalization of a partially hydrolyzed poly(2-ethyl-2-oxazoline) with γ-butyroselenolactone. The hydrogel spontaneously cross-links via an in situ oxidation of the selenol functionalities in air. The gelation process and the final viscoelastic properties of the gel are characterized by rheological experiments. The mechanical properties of those new diselenide-containing hydrogels are easily tuned by varying the concentration of γ-butyroselenolactone. The materials also show good skin adhesion and UV light responsiveness. A unique feature of the hydrogel is its capability to be fully and rapidly dissolved on-demand, via oxidation or reduction of the diselenide cross-links, making them particularly attractive for burn wound dressing applications.

show abstract

Section: Results and Discussionsupporting

confidence: 72%

On-Demand Dissoluble Diselenide-Containing Hydrogel

Imbernon

et al. 2020

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…HA is a non-toxic and nonallergic polymer that has demonstrated exciting effects on wound healing, including the promotion of epithelial cell migration, the decrease of inflammatory processes, enhancement of angiogenesis, and stimulation of endothelial cell proliferation and migration (8)(9)(10)(11)(12). Thus, in recent years, HA is increasingly employed for the design and manufacture of wound dressings with highly promising results (13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid in wound dressings

Cortés

Caballero-Florán

Mendoza‐Muñoz

et al. 2020

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Human skin possesses an essential function in the maintenance of individuals' health. However, it may undergo a variety of lesions that produce wounds of distinct severity. In this respect, instantly after any skin wound, the process of tissue regeneration and repair initiates. Nevertheless, diverse factors can delay this process, including bacterial infections, nutritional status, age, hypoxia, chronic diseases, necrosis, and vascular and arterial diseases. Thus, wound dressings are frequently used to improve wound healing. Those wound dressings are fabricated with diverse materials, which confer them different properties. In this regard, hyaluronic acid is a natural polysaccharide widely distributed in extracellular matrices of mammal tissues, which possesses remarkable attributes in terms of biocompatibility, biodegradability, and low cost. Moreover, hyaluronic acid exhibits several beneficial effects on wound healing, such as the decrease of inflammatory processes, regulation of tissue remodeling, and enhancement of angiogenesis. Therefore, in recent years, there is growing attention in this polysaccharide for the design and manufacture of novel wound dressings, which have shown encouraging properties. Here, we describe the different approaches of hyaluronic acid for the production of wound dressings, encompassing hydrogels, films, scaffolds, foams, topical formulations, and nanoformulations, as well as its beneficial effects on wound healing. Finally, we discuss perspectives about the use of hyaluronic acid in wound dressings.

show abstract

“…Here we report the facile synthesis of in situ crosslinking bionanocomposite hydrogels which deliver antimicrobial Zn 2+ and have potential for wound healing applications [64][65][66][67][68][69][70]. The simple addition of extra components enables the inclusion of multiple drugs to treat wounds with various microbial populations (or indeed for patients with multiple co-morbidities).…”

Section: Discussionmentioning

confidence: 99%

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Leone

Fırlak

Challen

et al. 2019

JFB

View full text Add to dashboard Cite

In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

show abstract

One-pot synthesis of ZnO nanobelt-like structures in hyaluronan hydrogels for wound dressing applications

Cited by 65 publications

References 31 publications

On-Demand Dissoluble Diselenide-Containing Hydrogel

On-Demand Dissoluble Diselenide-Containing Hydrogel

Hyaluronic acid in wound dressings

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Contact Info

Product

Resources

About