One-pot synthesis of α-aminonitriles from alkyl and aryl cyanides: a Strecker reaction via aldimine alanes

Acetone Cyanohydrin: A Convenient Alternative of Toxic Sodium Cyanide/Acetic Acid for Oxidative Cyanation of Tertiary Amines

“…Further, they can readily be converted into other useful products such as in a-amino acids either via hydrolysis or by nucleophilic additions to the nitrile group [5]. Therefore, the synthesis of these a-aminonitriles is significantly important both in synthetic as well as medicinal chemistry.…”

Expeditious and efficient synthesis of Strecker’s α-aminonitriles catalyzed by sulfated polyborate

“…The optimized protocol was also applied to the reaction of aromatic and aliphatic ketones. The reaction gives lower yield with longer reaction time as compared to aldehydes (Table 3, entries 15,16). Only a few extents of research on the Strecker reaction with ketones has been reported.…”

Eco-friendly synthesis of α-aminonitriles from ketones in PEG-400 medium using potassium Hexacyanoferrate(II) as cyanide source

“…In general, a-aminonitriles are synthesized by the reactions of aldehydes/ketones with amines in the presence of a cyanide source such as HCN [10,11], KCN [12], TMSCN [13,14], (EtO) 2 P(O)CN [15], Et 2 AlCN [16], Bu 3 SnCN [17,18], MeCOCN [19], acetone cyanohydrin [20,21] and ethyl cyanoformate [22,23]. However, these cyanide sources are often hazardous and toxic, and involve harsh reaction conditions.…”