One-pot synthesis of α,β-unsaturated ketones through sequential alkyne dimerization/hydration reactions using the Hoveyda–Grubbs catalyst

Abstract

Herein we report a sequential one-pot alkyne dimerization/hydration protocol for the regioselective synthesis of α,β-unsaturated ketones in quantitive yields. The alkyne dimerization reactions of terminal arylacetylenes proceeded with high regioselectivity...

Platinum-Catalyzed Hydrative Dimerization of Alkynylsilanes to α,β-Unsaturated Ketones

“…Hydrative dimerization of terminal alkynes leading to α,β-unsaturated ketones has been achieved under catalysis by Rh and Ru complexes. , We therefore anticipated that this transformation would involve the formation of free phenylacetylene from 1a by desilylation. To verify this possibility, phenylacetylene was used instead of 1a .…”