One-pot synthesis of β-amino carbonyl compounds catalyzed silica supported phenylphosphinic acid

Liu, Di; Zhang, Jingwei; Zhang, Chi; Kou, Xiaoyan

doi:10.1515/gps-2014-0077

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In contrast to 1,2-diaryl-3-arylamino-1-propanones, which are conveniently obtained through the direct condensation of a aryl methyl ketone, an aromatic aldehyde and an arylamine in the presence of various catalysts, [16][17][18] β-arylamino ketones lacking any substituent at position 2 of the oxopropylidene linker are usually prepared by replacing the quaternized, easily leaving dialkylamino group in ketonic Mannich base hydrochlorides with an arylamino moiety. 19 Using the latter synthetic approach, two different types of phenolic 1-aryl-3-arylamino-1-propanones can be prepared.…”

Section: Resultsmentioning

confidence: 99%

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

Roman¹

2017

Acta Chemica Iasi

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A small collection of 1-aryl-3-arylamino-1-propanones having a phenolic moiety in their structure has been obtained by the replacement of the tertiary amino group in ketonic Mannich bases with (hetero)aromatic amines. The installment of the phenolic moiety took place either through the N-alkylation of 4-aminophenol with ketonic Mannich base hydrochlorides, or via amine exchange in ketonic Mannich bases derived from either 2′-hydroxyacetophenone or 4′-hydroxyacetophenone.

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Section: Resultsmentioning

confidence: 99%

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

Roman¹

2017

Acta Chemica Iasi

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“…Liu et al managed to obtain similar products using cyclohexanone instead of acetophenone via the use of silica-supported phenylphosphinic acid in ethanol solvent at room temperature. Reactions were much faster (30-70 min), and yields were similarly high (67-96%) [99].…”

Section: Mannich-type Reactionsmentioning

confidence: 97%

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Bosica

Abdilla

2022

Catalysts

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Multicomponent reactions (MCRs) have been gaining significance and attention over the past decade because of their ability to furnish complex products by using readily available and simple starting materials while simultaneously eliminating the need to separate and purify any intermediates. More so, most of these products have been found to exhibit diverse biological activities. Another paradigm shift which has occurred contemporarily is the switch to heterogeneous catalysis, which results in additional benefits such as the reduction of waste and an increase in the safety of the process. More importantly, it allows the user to recover and reuse the catalyst for multiple runs. In summary, both methodologies adhere to the principles of green chemistry, a philosophy which needs to become overarchingly enshrined. The plethora of reactions and catalysts which have been developed gives hope that chemists are slowly changing their ideology. As a result, this review attempts to discuss multicomponent reactions catalysed by operationally heterogeneous catalysts in the past 10 years. In this review, a further distinction is made between the MCRs which lead to the formation of heterocycles and those which do not.

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Novel aminobenzenesulfonamides as potential inhibitors of carbonic anhydrases

ROMAN

2024

Rev.Roum.Chim.

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A synthetic approach to N-[3-(hetero)aryl-3-oxoprop-1-yl]sulfonamides by N-alkylation of sulfanilamide with structurally diverse ketone Mannich base hydrochlorides is being reported. This scarcely explored synthetic strategy that involves aminomethylated ketones as starting materials has afforded novel compounds, potentially useful as inhibitors of carbonic anhydrases, with moderate to good yields.

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One-pot synthesis of β-amino carbonyl compounds catalyzed silica supported phenylphosphinic acid

Cited by 3 publications

References 26 publications

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Novel aminobenzenesulfonamides as potential inhibitors of carbonic anhydrases

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