One-pot three-component synthesis of novel pyrano[3,2-e]pyrazolo[1,5-a]pyrimidines and investigation of their biological activities

In vitro biological studies and computational prediction-based analyses of pyrazolo[1,5-a]pyrimidine derivatives

“…36 12.12 ± 0.40 mM. 37 Peytam and co-workers prepared substituted 6-amino-pyrazolo[1,5-a]pyrimidine 4 as an anti-diabetic agent through the inhibition of a-glucosidase enzyme with an activity IC 50 of 15.2 ± 0.4 mM, which is more potent than acarbose (IC 50 = 750.0 ± 1.5 mM) by around 50-fold. 38 From our previous cooperation, Hassan et al designed and prepared some 5-arylpyrazolo[1,5-a]pyrimidine derivatives as multi-target candidates and concluded that the 7-amino-6-cyano-pyrazolo[1,5-a] pyrimidine-3-carboxamide derivative 5 showed powerful activities as an antioxidant and anti-diabetic agent.…”

“… 36 Additionally, Vahedi et al synthesized 8-(cyclohexylamino)-2,5-dimethyl-6 H -pyrano[3,2- e ]pyrazolo[1,5- a ]pyrimidine derivative 2, which showed potent cytotoxicity against MCF-7 breast cells with IC 50 = 19.70 ± 0.89 μM; they also prepared another 5-(2-ethoxy-2-oxoethyl)-6 H -pyrano[3,2- e ]pyrazolo[1,5- a ]pyrimidinederivative 3 as an antioxidant agent, which exhibited free radical scavenging activity with IC 50 = 12.12 ± 0.40 μM. 37 Peytam and co-workers prepared substituted 6-amino-pyrazolo[1,5- a ]pyrimidine 4 as an anti-diabetic agent through the inhibition of α-glucosidase enzyme with an activity IC 50 of 15.2 ± 0.4 μM, which is more potent than acarbose (IC 50 = 750.0 ± 1.5 μM) by around 50-fold. 38 From our previous cooperation, Hassan et al designed and prepared some 5-aryl-pyrazolo[1,5- a ]pyrimidine derivatives as multi-target candidates and concluded that the 7-amino-6-cyano-pyrazolo[1,5- a ]pyrimidine-3-carboxamide derivative 5 showed powerful activities as an antioxidant and anti-diabetic agent.…”

Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies

“…Various synthetic compounds with heterocyclic moieties have become recognized for their antiviral properties [ 27 , 28 ]. Therefore, pyranopyrazole moieties and their annulated systems are a special structure of bioactive fused heterocyclic structures that have developed attentive significance in biochemistry due to their various pharmacological and biological efficiencies such as human Chk1 kinase inhibitors [ 29 ], antimicrobial agents [ 30 ], molluscicidal agents [ 31 ], analgesic [ 32 ], anti-bacterial [ 33 ], anti-inflammatory [ 22 ], antiproliferative [ 34 ], antifungal [ 35 ], anti-depressant [ 36 ], antioxidant [ 37 ], antimalarial [ 38 ], α-glucosidase inhibitors [ 39 ], anti-cancer [ 40 ], biodegradable agrochemicals [ 41 ], and anti-Alzheimer efficiencies [ 42 ].…”

Development of CuMnxOy (x = 2, and y = 4)-GO heterostructure for the synthesis of pyranoquinoline derivatives

“…The pyranoquinoline derivatives are an important group of heterocyclic compounds in the field of organic chemistry due to pharmaceutical and biological properties such as antimalarial 3 , anticancer 4 , antimicrobial 5 , etc. Many studies have offered various methods for the synthesis of pyranoquinoline derivatives, such as the use of microwave radiation 6 , ultrasonic radiation 7 , room temperature 8 , nanocatalysts 9 , Hack reaction 10 , and Diels–Alder reaction 11 . Therefore, pyranoquinolines were synthesized in the presence of nanocatalysts in a pure form with high efficiency 12 .…”