One-pot wet-chemical fabrication of 3D urchin-like core-shell Au@PdCu nanocrystals for electrochemical breast cancer immunoassay

Chen, Di-Nan; Wang, Ai‐Jun; Feng, Jiu‐Ju; Cheang, Tuck Yun

doi:10.1007/s00604-023-05932-7

Cited by 6 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The coefficient of R 2 (0.995) indicates excellent correlation. According to the principle of S/N = 3, the LOD , of an anodic PEC sensor is 0.014 U/mL, which is comparable with other strategies − for the detection of CA15-3 (Table S2). In contrast, for the cancer marker of CEA using a cathodic PEC sensor, the relationship is positively linear with the marker concentration, and the LOD is as low as 0.0023 ng/mL, which is superior to most methods − for sensing CEA (Table S3).…”

Section: Resultsmentioning

confidence: 57%

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Zhong,

Ding,

Man

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

Breast cancer poses the significance of early diagnosis and treatment. Here, we developed an innovative photoelectrochemical (PEC) immunosensor characterized by high-level dual photocurrent signals and exceptional sensitivity. The PEC sensor, denoted as MIL&Ag 2 S, was constructed by incorporating Ag 2 S into a metal−organic framework of MIL-101(Cr). This composite not only enhanced electron−hole separation and conductivity but also yielded robust and stable dual photocurrent signals. Through the implementation of signal switching, we achieved the combined detection of cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) with outstanding stability, reproducibility, and specificity. The results revealed a linear range for CEA detection spanning 0.01−32 ng/mL, with a remarkably low detection limit of 0.0023 ng/mL. Similarly, for CA15-3 detection, the linear range extended from 0.1 to 320 U/mL, with a low detection limit of 0.014 U/mL. The proposed strategy introduces new avenues for the development of highly efficient, cost-effective, and user-friendly PEC sensors. Furthermore, it holds promising prospects for early clinical diagnosis, contributing to potential breakthroughs in medical detection and ultimately improving patient outcomes.

show abstract

Section: Resultsmentioning

confidence: 57%

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Zhong,

Ding,

Man

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Facile wet chemical synthesis produces colloidal dispersions of various nanoparticle–graphene composites [ 85 ]. Common combinations utilized in electrochemical biosensors include graphene–gold [ 86 ], graphene–platinum [ 60 ], graphene–silver [ 87 ], graphene–iron oxide [ 88 ] and graphene–metal oxides like CuO and TiO 2 [ 81 , 89 ].…”

Section: Graphene Electrochemical Biosensorsmentioning

confidence: 99%

“…Common combinations utilized in electrochemical biosensors include graphene–gold [ 86 ], graphene–platinum [ 60 ], graphene–silver [ 87 ], graphene–iron oxide [ 88 ] and graphene–metal oxides like CuO and TiO 2 [ 81 , 89 ]. Hydrothermal approaches [ 85 ], electrostatic assembly [ 90 ], electrophoretic deposition [ 91 ], and electrochemical reduction methods [ 51 ] allow for nanoscale control over morphology and composition. Figure 5 shows the morphology of several graphene-based nanocomposites.…”

Section: Graphene Electrochemical Biosensorsmentioning

confidence: 99%

Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis

Fu,

Zheng,

et al. 2023

Molecules

View full text Add to dashboard Cite

Graphene is an emerging nanomaterial increasingly being used in electrochemical biosensing applications owing to its high surface area, excellent conductivity, ease of functionalization, and superior electrocatalytic properties compared to other carbon-based electrodes and nanomaterials, enabling faster electron transfer kinetics and higher sensitivity. Graphene electrochemical biosensors may have the potential to enable the rapid, sensitive, and low-cost detection of cancer biomarkers. This paper reviews early-stage research and proof-of-concept studies on the development of graphene electrochemical biosensors for potential future cancer diagnostic applications. Various graphene synthesis methods are outlined along with common functionalization approaches using polymers, biomolecules, nanomaterials, and synthetic chemistry to facilitate the immobilization of recognition elements and improve performance. Major sensor configurations including graphene field-effect transistors, graphene modified electrodes and nanocomposites, and 3D graphene networks are highlighted along with their principles of operation, advantages, and biosensing capabilities. Strategies for the immobilization of biorecognition elements like antibodies, aptamers, peptides, and DNA/RNA probes onto graphene platforms to impart target specificity are summarized. The use of nanomaterial labels, hybrid nanocomposites with graphene, and chemical modification for signal enhancement are also discussed. Examples are provided to illustrate applications for the sensitive electrochemical detection of a broad range of cancer biomarkers including proteins, circulating tumor cells, DNA mutations, non-coding RNAs like miRNA, metabolites, and glycoproteins. Current challenges and future opportunities are elucidated to guide ongoing efforts towards transitioning graphene biosensors from promising research lab tools into mainstream clinical practice. Continued research addressing issues with reproducibility, stability, selectivity, integration, clinical validation, and regulatory approval could enable wider adoption. Overall, graphene electrochemical biosensors present powerful and versatile platforms for cancer diagnosis at the point of care.

show abstract

Atomically Co-dispersed nitrogen-doped carbon for sensitive electrochemical immunoassay of breast cancer biomarker CA15-3

Han,

Cai,

Chen

2024

Microchim Acta

View full text Add to dashboard Cite

One-pot wet-chemical fabrication of 3D urchin-like core-shell Au@PdCu nanocrystals for electrochemical breast cancer immunoassay

Cited by 6 publications

References 44 publications

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis

Atomically Co-dispersed nitrogen-doped carbon for sensitive electrochemical immunoassay of breast cancer biomarker CA15-3

Contact Info

Product

Resources

About

One-pot wet-chemical fabrication of 3D urchin-like core-shell Au@PdCu nanocrystals for electrochemical breast cancer immunoassay

Cited by 6 publications

References 44 publications

Versatile Metal–Organic Framework Incorporating Ag2S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Versatile Metal–Organic Framework Incorporating Ag2S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis

Atomically Co-dispersed nitrogen-doped carbon for sensitive electrochemical immunoassay of breast cancer biomarker CA15-3

Contact Info

Product

Resources

About

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers

Versatile Metal–Organic Framework Incorporating Ag₂S for Constructing a Photoelectrochemical Immunosensor for Two Breast Cancer Markers