One-pot α-ferrocenylalkylation of amines and alcohols with α-ferrocenyl substituted alcohols under acid-free conditions

Ferrocenyl alkylation of 4‐mercapto derivatives of sydnones and sydnone imines. New antidotes for sulfonylurea herbicides

“…We have previously reported a convenient methodology for the ferrocenyl alkylation of alcohols, heterocyclic thiols, and amino acids with (α-ferrocenylalkyl) carbonates under mild acid-free conditions. [25][26][27][28] The application of this method not only allowed us to obtain ferrocenyl sydnone imines (Table 2) but also made it possible to solve the problem of the inertness of 4-mercaptosydnones in the alkylation reaction under the action of α-hydroxy derivatives of ferrocene. The target ferrocene-containing 4-thiosydnones 3 were obtained in moderate yields.…”

One‐pot acid‐free ferrocenylalkylation of azoles with α‐ferrocenyl alcohols: ferrocene‐based plant growth regulators and herbicide safeners

“…[25,26] Carbonates 2 spontaneously decompose under neutral conditions even at room temperature producing the αferrocenylcarbocation that interacts with the nucleophile (or pre-nucleophile) NuH furnishing the α-ferrocenylalkylation product 3 (Scheme 1). [25,26] Carbonates 2 spontaneously decompose under neutral conditions even at room temperature producing the αferrocenylcarbocation that interacts with the nucleophile (or pre-nucleophile) NuH furnishing the α-ferrocenylalkylation product 3 (Scheme 1).…”

The nature of ferrocenylalkylating agent in the acid-catalyzed reactions with ferrocenyl(phenyl)methanol

“…Recent examples include the use of ferro cenyl carbonates for alkylation of various nucleophiles in neutral and basic media. [14][15][16] Nevertheless, α-ferrocenyl-substituted alcohols are currently the most common alkylating agents. This is primarily due to their stability, simple handling, and a wide range of methods for their preparation.…”