One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving

Camprodon, Joan A.; Martı́nez-Raga, José; Alonso‐Alonso, Miguel; Shih, Mei‐Chiung; Pascual‐Leone, Álvaro

doi:10.1016/j.drugalcdep.2006.06.002

Cited by 237 publications

(178 citation statements)

References 18 publications

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“…In the fi rst study, Camprodon et al (2007) administered two sessions of 10 Hz rTMS to the right or left DLPFC at 90% resting motor threshold in a randomized cross-over design in six subjects. The level of cocaine cravings were assessed with VAS 10 min before, immediately following, and 4 h following rTMS.…”

Section: Treatment Of Cocaine Addiction With Rtmsmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation and drug addiction

Barr

Farzan

Wing

et al. 2011

International Review of Psychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that is now being tested for its ability to treat addiction. This review discusses current research approaches and results of studies which measured the therapeutic use of rTMS to treat tobacco, alcohol and illicit drug addiction. The research in this area is limited and therefore all studies evaluating the therapeutic use of rTMS in tobacco, alcohol or illicit drug addiction were retained including case studies through NCBI PubMed (http://www.ncbi.nlm.nih.gov) and manual searches. A total of eight studies were identifi ed that examined the ability of rTMS to treat tobacco, alcohol and cocaine addiction. The results of this review indicate that rTMS is effective in reducing the level of cravings for smoking, alcohol, and cocaine when applied at high frequencies to the dorsolateral prefrontal cortex (DLPFC). Furthermore, these studies suggest that repeated sessions of high frequency rTMS over the DLPFC may be most effective in reducing the level of smoking and alcohol consumption. Although work in this area is limited, this review indicates that rTMS is a promising modality for treating drug addiction.

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Section: Treatment Of Cocaine Addiction With Rtmsmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation and drug addiction

Barr

Farzan

Wing

et al. 2011

International Review of Psychiatry

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“…The data that emerge from this experiment may provide a neurobiological basis for the emerging data that a potentiating form of repetitive transcranial magnetic stimulation (TMS) to the DLPFC ( (Camprodon et al, 2007;Politi et al, 2008;Terraneo et al, 2016), or an attenuating form of TMS to the MPFC (Hanlon et al, 2015) appears to dampen craving among cocaine users. To minimize the impact of the methodological and human subject's factors, we employed an experimental technique that activates the prefrontal cortex (like many task-based studies) without requiring the individual to concentrate on a task.…”

Section: Introductionmentioning

confidence: 99%

Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

Hanlon

Dowdle

Moss

et al. 2016

Neuropsychopharmacol

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The integrity of frontal-striatal circuits is an area of great interest in substance dependence literature, particularly as the field begins to develop neural circuit-specific brain stimulation treatments for these individuals. Prior research indicates that frontal-striatal connectivity is disrupted in chronic cocaine users in a baseline (resting) state. It is unclear, however, if this is also true when these circuits are mobilized by an external source. In this study, we measured the functional and structural integrity of frontal-striatal circuitry involved in limbic arousal and executive control in 36 individuals-18 cocaine-dependent individuals with a history of failed quit attempts and 18 age-matched controls. This was achieved by applying a transcranial magnetic stimulation to the medial prefrontal cortex (Brodmann area 10) and the dorsolateral prefrontal cortex (lateral Brodmann 9) while participants rested in the MRI scanner (TMS/BOLD imaging). Relative to the controls, cocaine users had a lower ventral striatal BOLD response to MPFC stimulation. The dorsal striatal BOLD response to DLPFC stimulation however was not significantly different between the groups. Among controls, DLPFC stimulation led to a reciprocal attenuation of MPFC activity (BA 10), but this pattern did not exist in cocaine users. No relationship was found between regional diffusion metrics and functional activity. Considered together these data suggest that, when engaged, cocaine users can mobilize their executive control system similar to controls, but that the 'set point' for mobilizing their limbic arousal system has been elevated-an interpretation consistent with opponent process theories of addiction.

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“…For instance, noninvasive brain stimulation, namely repetitive transcranial magnetic stimulation (rTMS), of the DLPFC significantly reduces smoking (Eichhammer et al, 2003;Fregni et al, in press), cocaine (Camprodon, Martinez-Raga, Alonso-Alonso, Shih, & Pascual-Leone, 2007) and alcohol (Boggio et al, 2008) craving. Indeed, one of the most important areas participating in the cue-associated anticipation and planning of drug use involves DLPFC, an area involved in planning and memory (Wilson, Sayette, & Fiez, 2004).…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods

et al. 2008

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We aimed to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) with noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies food craving in healthy subjects. We performed a randomized sham-controlled cross-over study in which 23 subjects received sham and active tDCS (anode left/cathode right and anode right/ cathode left) of the DLPFC. Subjects were exposed to food and also watched a movie of food associated with strong craving. Desire for food consumption was evaluated by visual analogue scales (VAS) and food consumption before and after treatment. In addition we measured visual attention to food using an eye tracking system. Craving for viewed foods as indexed by VAS was reduced by anode right/cathode left tDCS. After sham stimulation, exposure to real food or foodrelated movie increased craving; whereas after anode left/cathode right tDCS, the food-related stimuli did not increase craving levels, as revealed by the VAS scale. Moreover, compared with sham stimulation, subjects fixated food-related pictures less frequently after anode right/cathode left tDCS and consumed less food after both active stimulation conditions. These changes were not related to mood changes after any type of tDCS treatment. The effects of tDCS on food craving might be related to a modulation of neural circuits associated with reward and decisionmaking.

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One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving

Cited by 237 publications

References 18 publications

Repetitive transcranial magnetic stimulation and drug addiction

Repetitive transcranial magnetic stimulation and drug addiction

Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study

Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods

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