One-Stage Homotransplantation of the Liver Following Total Hepatectomy in Dogs

The past 60 years in liver surgery

“…A half century later, in 1955, Welch published the first description of a technique for liver transplantation in animals, 86 and the first experimental animal liver transplantation subsequently was performed by Moore and colleagues in 1959. 87 That work set the stage for the first human liver transplantation in 1963. 88 Unfortunately, the child aged 3 years with biliary atresia who received this first liver transplantation survived for only hours after receiving the graft.…”

A Brief History of Clinical Organ Transplantation

“…Nevertheless, during this phase techniques of experimental heart transplantation were developed by Lower and Shumway in Stanford [31]. Additionally, Starzl in Denver and Francis Moore at the Peter Bent Brigham Hospital in Boston each developed successful surgical techniques for transplanting the liver [32,33]. Experimentally head and limb transplants were performed by Demikov in Moscow, but at that time these were little more than a surgical curiosity rather than a serious move forward towards clinical application [34].…”

The Routinely Use of “Piggyback” Technique in Adult Orthotopic Liver Transplantation

“…Unfortunately, their model in dogs, did not tolerate blood flow interruption neither at the IVC, nor at the portal vein because they supposed half of the venous return of the animal. Bypass dispositive had to be developed to avoid the hemodynamic compromise that the total hepatectomy supposed in the animal (Moore, 1959) and, in the end, they were included as routine tools for transplantation surgery in the first era. Nevertheless, Calne and Starzl noticed that in human adults, it was not always necessary to bypass neither portal nor inferior cava vein blood flow during the anhepatic phase of the transplantation (Calne, 2008).…”