One-Step Conversion of Methyl Ketones to Acyl Chlorides

Abstract

Treatment of aromatic and heteroaromatic methyl ketones with sulfur monochloride and catalytic amounts of pyridine in refluxing chlorobenzene leads to the formation of acyl chlorides. Both electron-rich and electron-poor aryl methyl ketones can be used as starting materials. The resulting C1-byproduct depends on the precise reaction conditions chosen.

The Conversion of tert-Butyl Esters to Acid Chlorides Using Thionyl Chloride

“…This compound was prepared according to the general procedure with an extended reaction time of 16 h and run in toluene (0.1 M), heated to 100 °C to provide 2i (0.080 g, 94%). 1 H and 13 C NMR are in accord with those reported in the literature …”

Modified Ferrocenes as Primary Driers for Formulations of Alkyd Paints

“…Yield: 14.6 g (86 mmol, 86%). Analytical and spectroscopic data are in line with those reported elsewhere [31].…”

Atom-efficient chlorination of benzoic acids with PCl3 generating acyl chlorides

“…We removed the reaction solution and washed the solid with toluene several times. After it was dried under vacuum, the solid obtained was dissolved in dimethyl sulfoxide (DMSO)-d6 and analyzed by 31 P NMR and 1 H spectrascopy. As depicted in Figure 1, two signals were observed at δ 2.16 and δ 0.09, respectively (ratio: 2.8/1.0), that accounted for phosphorus.…”