One-step dry synthesis of an iron based nano-biocomposite for controlled release of drugs

Varghese, Sophia; Chaudhary, Jai Prakash; Ghoroi, Chinmay

doi:10.1039/d0ra01133a

Cited by 12 publications

(9 citation statements)

References 43 publications

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“…Conversely, the FeCNB spectrum displayed a distinctive peak at 630 cm −1 , which is attributed to the presence of the FeO group. 31 Importantly, none of the spectra for FeCNB films exhibited new peaks, suggesting the absence of covalent interactions between FeCNB and SA films. However, it is worth noting that there are changes in the intensity with a slight shift in the position of the peaks.…”

Section: Resultsmentioning

confidence: 98%

“…In Figure 3A, the XRD spectrum of FeCNB aligns well with the literature. 31 These peaks signify the presence of graphene and magnetite. The SA film displays characteristic peaks at 10.45°a nd 21.45°.…”

Section: Resultsmentioning

confidence: 99%

“…Synthesis of FeCNB and Fabrication of FeCNB-Incorporated Films. FeCNB was synthesized using a previously described method 31 (referred to as nano FeCNB). Precisely, FAS and SA were weighed in a ratio of 1:6 and mixed thoroughly in a mortar.…”

Section: Methodsmentioning

confidence: 99%

“…The developed nanocomposite exhibited a porous structure with magnetic properties and biocompatibility. 31 In the present study, FeCNB is incorporated into SA film, a biodegradable and biocompatible material, to serve as a nanofiller. It is hypothesized that the incorporation of FeCNB enhances the physicochemical properties of the SA film, including its cell adhesion properties and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

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Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Kumawat,

Dave,

Varghese

et al. 2024

ACS Appl. Mater. Interfaces

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Sodium alginate (SA) biopolymeric films have various limitations such as poor mechanical properties, high vapor permeability, lack of antibacterial activity, excessive burst release, and weak cell adhesion. To overcome these limitations, a strategy involving the integration of nanofillers into an SA film matrix is explored. In this context, a cost-effective iron-containing carbon nano biocomposite (FeCNB) nanofiller is developed using a solvent-free technique. This nanocomposite is successfully incorporated into the alginate film matrix at varying concentrations (0.05, 0.1, and 0.15%) aimed at enhancing its physicochemical and biological properties for biomedical applications. Characterization through FESEM and BET analyses confirms the porous nature of the FeCNB. EDX shows the FeCNB's uniform distribution upon its integration into the film matrix, albeit without strong chemical interaction with SA. Instead, hydrogen bonding interactions become apparent in the FTIR spectra. By incorporating the FeCNB, the mechanical attributes of the films are improved and the water vapor permeability approaches the desired range (2000−2500 g/ m 2 day). The film's swelling ratio reduction contributes to a decrease in water permeability. The antibacterial activity and sustained release property of the FeCNB-incorporated film are established using tetracycline hydrochloride (TCl), a model drug. The drug release profile resembled Korsmeyer-Peppas's release pattern. In vitro assessments via the MTT assay and scratch assay on NIH-3T3 cells reveal that FeCNB has no adverse effects on the biocompatibility of alginate films. The cell proliferation and adhesion to the SA film are significantly enhanced after infusion of the FeCNB. The in vivo study performed on the rat model demonstrates improved wound healing by FeCNB-impregnated films. Based on the comprehensive findings, the proposed FeCNB-incorporated alginate films prove to be a promising candidate for robust skin repair.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Kumawat,

Dave,

Varghese

et al. 2024

ACS Appl. Mater. Interfaces

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“…The peak at 290.06 eV is attributed to residual (C1s) impurities that have adsorbed on the sample’s surface when it was exposed to air, while the peak at 405.62 eV is attributed to N1s, which may be associated with the use of (NH 4 )H 2 PO 4 during the preparation. The binding energy at 715.98 eV corresponds to Fe 3+ (indicating the presence of Fe 2 O 3 ), while 728.72 eV corresponds to Fe 2+ (suggesting the presence of Fe 3 (PO 4 ) 2 , a form of nanostructured iron phosphate) [ 45 – 47 ]. The observed Cu2p3/2 and Cu2p1/2 binding energies (937.08 eV and 957.88 eV) correspond to the Cu2p3/2 and Cu2p1/2 core-level electrons, respectively.…”

Section: Discussionmentioning

confidence: 99%

Iron/Copper/Phosphate nanocomposite as antimicrobial, antisnail, and wheat growth-promoting agent

Abdullah,

Elbialy,

Amer

et al. 2024

BMC Biotechnol

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Background One of the current challenges is to secure wheat crop production to meet the increasing global food demand and to face the increase in its purchasing power. Therefore, the current study aimed to exploit a new synthesized nanocomposite to enhance wheat growth under both normal and drought regime. The effectiveness of this nanocomposite in improving the microbiological quality of irrigation water and inhibiting the snail’s growth was also assessed. Results Upon the employed one-step synthesis process, a spherical Fe/Cu/P nanocomposite was obtained with a mean particle size of 4.35 ± 1.524 nm. Cu2+, Fe2+, and P4+ were detected in the dried nanocomposite at 14.533 ± 0.176, 5.200 ± 0.208, and 34.167 ± 0.203 mg/ml concentration, respectively. This nanocomposite was found to exert antibacterial activity against Escherichia coli and Salmonella typhi. It caused good inhibition percent against Fusarium oxysporum (43.5 ± 1.47%) and reduced both its germination rate and germination efficiency. The lethal concentration 50 (LC50) of this nanocomposite against Lanistes carinatus snails was 76 ppm. The treated snails showed disturbance in their feeding habit and reached the prevention state. Significant histological changes were observed in snail digestive tract and male and female gonads. Drought stress on wheat’s growth was mitigated in response to 100 and 300 ppm treatments. An increase in all assessed growth parameters was reported, mainly in the case of 100 ppm treatment under both standard and drought regimes. Compared to control plants, this stimulative effect was accompanied by a 2.12-fold rise in mitotic index and a 3.2-fold increase in total chromosomal abnormalities. Conclusion The finding of the current study could be employed to mitigate the effect of drought stress on wheat growth and to enhance the microbiological quality of irrigation water. This is due to the increased efficacy of the newly synthesized Fe/Cu/P nanocomposite against bacteria, fungi, and snails. This methodology exhibits potential for promoting sustainable wheat growth and water resource conservation.

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Controlled Fabrication and Characterization of α-FeOOH Nanorods

Zhang

et al. 2022

J Inorg Organomet Polym

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One-step dry synthesis of an iron based nano-biocomposite for controlled release of drugs

Abstract: Schematics for synthesis and application of magnetic nano-biocomposite for control release of DOX.

Cited by 12 publications

References 43 publications

Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair

Iron/Copper/Phosphate nanocomposite as antimicrobial, antisnail, and wheat growth-promoting agent

Controlled Fabrication and Characterization of α-FeOOH Nanorods

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