One-step liquid chromatographic method for the determination of oxytetracycline in fish muscle

Liquid chromatographic determination and depletion profile of oxytetracycline in milk after repeated intramuscular administration in sheep

“…However, it is well known [9,24] that this technique suffer from batch-to-batch variability and column clogging, and is invariably time consuming to use, in addition to adding to the cost of the sample preparation.…”

The processes affecting oxytetracycline contamination of groundwater in a phreatic aquifer underlying industrial fish ponds in Israel

“…It is also biologically active in humans. This particular antibiotic is the main focus of this study, for, it is widely used in aquaculture, mainly as a growth promoter and to prevent infection (Coyne et al 2004). Lalumera et al (2004) found that 75% of the given drug is released from the body of the fish through secretions as a non-metabolite molecule, which directly discharges to the aquatic environment.…”

Simultaneous determination of selected veterinary antibiotics in gilthead seabream (Sparus Aurata) by liquid chromatography–mass spectrometry

“…For this reason, other techniques, such as chromatography or electrophoresis [9], have been proposed to overcome these shortcomings, and liquid chromatography (LC) is the most frequently approach used. In relation to detection methods, they are diverse and include UV [10,11] or fluorescence detection [12,13]. However, Public Health Agencies, based on European Union guidelines, rely on the detection by mass spectrometry (MS) for confirmation of antibiotics in foodstuffs [14], considering that it provides more reliable identification and confirmation of these analytes than conventional detectors.…”