One-step Preparation of Antibacterial Gelatin/Polycaprolactone Nanofibrous Janus Membranes for Efficient Hemostasis

Abstract

One cannot overstate the advantages of an ideal hemostasis material for the emergency rescue of wars and traffic accident victims, and it can significantly mitigate patient distress and minimize threat to life. Nonetheless, it is still a daunting task to obtain a hemostasis material encompassing desirable advantages, including safety, antibacterial activity, high efficiency, sufficient mechanical strength, cost-effectiveness, and so on. In this study, a one-step electrospinning strategy for achieving an efficient hemostatic membrane with a Janus structure is provided. Owing to the synergistic coagulation effect between gelatin nanofibers and zeolite powders (hydrophilic layer), the membrane exhibits excellent coagulation performance in vitro. Simultaneously, the hydrophobic layer's efficacy in preventing blood permeation further shortens bleeding time and lessens blood loss in vivo. Moreover, the membrane presents commendable flexibility, antibacterial activity, hemocompatibility, and noncytotoxicity, with promise to be used as a safe and efficient hemostatic dressing in clinical applications.

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

“…The versatility of this technology is manifested in the wide variety of configurations that can be used for fiber mats production. Among others, the use of multiple-fluid (e.g., coaxial or triaxial) electrospinning, dual spinneret, coelectrospinning, Janus structures, or several combinations allows the production of really advanced macromolecular structures. − Moreover, the combination of electrospinning with other technologies (laser, additive manufacturing techniques, electrohydrodynamic atomization, etc.) for improving biological performance is also possible. , Among other biopolymers and derivatives, ethyl cellulose (EC) is known to be hydrophobic, stable (both thermally and mechanically), and nontoxic, presenting an interesting option due to its safety and biocompatibility.…”

Fluorescence-Selective Absorption and Circularly Polarized Fluorescence Energy Transfer Assist the Generation of Multicolor Circularly Polarized Luminescence in Chiral Helical Polyacetylene-Based Janus Nanofibers

“…Delightedly, the past few years have witnessed the rapid development of an electrospinning technique, and it has proved to be an effective method for constructing flexible and continuous CPL nanofibers with a controlled morphology, uniformity, and the desired optical properties. − The advantages of electrospinning include ease of operation, reliable reproducibility, and low cost. Moreover, multilevel structured nanofibers have also been realized by electrospinning. , For instance, Janus nanofibers composed of two distinct materials or phases within a single fiber can be prepared by using a parallel electrospinning nozzle. − It can be expected that introducing a Janus structure into CPL nanofibers has many scientific significances, including (1) offering more options for chiral and fluorescence substances, especially the ones with different compatibility (e.g., one is water-soluble and the other is oil-soluble), and (2) providing a spatial isolation between a chiral substance and a fluorescence substance for better understanding the CPL generation mechanism/process. Unfortunately, to the best of our knowledge, there has been no report concerning CPL-active Janus nanofibers so far.…”