One-step preparation of branched PEG functionalized AIE-active luminescent polymeric nanoprobes

Chu, Jun; Lv, Qiulan; Guo, Chunliang; Xü, Dong; Wang, Ke; Huang, Hongye; Zhang, Xiaoyong; Wei, Yen

doi:10.1007/s11426-016-5578-z

Cited by 12 publications

(3 citation statements)

References 58 publications

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“…PEGylation is a process in which activated polyethylene glycol chains are covalently coupled to proteins and organic molecules by chemical methods. 63 With irreplaceable advantages of low toxicity, antigenicity, and good amphiphilicity, the PEG-functionalized nanomaterials could enter the body smoothly and hold promise for widespread applications in optical bioimaging. In our work, we have attempted to use the modified hydrophobic carbon quantum dots for in vivo application for the first time.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Hydrophobic Carbon Dots Derived from Organic Pollutants and Applications in NIR Anticounterfeiting and Bioimaging

et al. 2023

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In an effort to fulfill the strategy of sustainable development, Rhodamine B, a common and toxic organic pollutant in the textile industry, was reported for the first time as a single precursor to develop a kind of novel hydrophobic nitrogen-doped carbon dot (HNCD) through a green and facile one-pot solvothermal method. The HNCDs with an average size of 3.6 nm possess left and right water contact angles of 109.56°and 110.34°, respectively. The HNCDs manifest excitation wavelengthtunable and upconverted fluorescence from the ultraviolet (UV) to the near-infrared (NIR) range. Furthermore, the PEGylation of HNCDs enables them to be used as an optical marker for cell and in vivo imaging. Notably, the HNCDs with solvent-dependent fluorescence can be used for invisible inks with a wide range of light responses from UV−vis−NIR spectra. This work not only provides an innovative way to recycle chemical waste but also expands the potential application of HNCDs in NIR security printing and bioimaging.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Hydrophobic Carbon Dots Derived from Organic Pollutants and Applications in NIR Anticounterfeiting and Bioimaging

et al. 2023

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“…[2a–c,4] The combination therapies have been recognized as an effective strategy to improve their anticancer efficacies through their respective cell damage mechanisms. [4d,5] Many efforts have been made to improve the phototherapeutic efficacy through PDT/PTT synergy or photoinduced drug delivery, and their synergistic effects play a key role in maximizing their therapeutic efficacies,[5k,6] For instance, PTT of cyanine dyes can enhance chemotherapeutic efficacy through light‐induced drug release or cytoplasmic drug translocation. [2b,c,4c,e] Photothermal effect can also inhibit the expression of multidrug resistance‐associated protein 1 (MRP1) to reduce the efflux of a Pt (IV) prodrug for causing synergistic cytotoxicity against resistant A549 cells.…”

Section: Introductionmentioning

confidence: 99%

Mutually Synergistic Nanoparticles for Effective Thermo‐Molecularly Targeted Therapy

Luo

Wang

Deng

et al. 2017

Adv Funct Materials

104

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Photothermal therapy (PTT) is of particular importance as a highly potent therapeutic modality in cancer therapy. However, a critical challenge still remains in the exploration of highly effective strategy to maximize the PTT efficiency due to tumor thermoresistance and thus frequent tumor recurrence. Here, a rational fabrication of the micelles that can achieve mutual synergy of PTT and molecularly targeted therapy (MTT) for tumor ablation is reported. The micelles generate both distinct photothermal effect from Cypate through enhanced photothermal conversion efficiency and pH-dependent drug release. The micelles further exhibit effective cytoplasmic translocation of 17-allylamino-17-demethoxygeldanamycin (17AAG) through reactive oxygen species mediated lysosomal disruption caused by Cypate under irradiation. Translocated 17AAG specifically bind with heat shock protein 90 (HSP90), thereby inhibiting antiapoptotic p-ERK1/2 proteins for producing preferable MTT efficiency through early apoptosis. Meanwhile, translocated 17AAG molecules further block stressfully overexpressed HSP90 under irradiation and thus inhibit the overexpression of p-Akt for achieving the reduced thermoresistance of tumor cells, thus promoting the PTT efficiency through boosting both early and late apoptosis of Cypate. Moreover, the micelles possess enhanced resistance to photobleaching, preferable cellular uptake, and effective tumor accumulation, thus facilitating mutually synergistic PTT/MTT treatments with tumor ablation. These findings represent a general approach for potent cancer therapy.

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“…Polyethylene glycol (PEG) is a hydrophilic linear polymer and the most popular surface-passivating material. Moreover, PEG has been widely used to functionalize CDs for improving their PL performance. , However, the research on the CDs made from PEG as the carbon source has been rarely reported, and the obtained CDs usually suffer from low quantum yield (QY) and are easily quenched under strong acidic condition. For example, Fan et al used PEG with different molar weights (PEG 400N , PEG 1500N , and PEG 6000N ) as the carbon source to prepare CDs by a simple hydrothermal method, and their QYs were lower than 4%.…”

Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Acidophilic Highly-Photoluminescent Carbon Dots Modified by Ionic Liquid from Polyethylene Glycol

Chen

Yang

et al. 2017

ACS Omega

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Acidophilic highly-photoluminescent ionic liquid (IL)-modified carbon dots (CDs) were fabricated directly from polyethylene glycol-2000 (PEG 2000N ) by a simple one-step hydrothermal method in a system containing an IL (1-butyl-3-methylimidazolium bromide [C 4 mim]Br) and hydrochloric acid (HCl). In this process, PEG 2000N works as the carbon source, [C 4 mim]Br as the modifier, and HCl as the accelerator. CDs with low photoluminescence (PL) intensity and quantum yields (QYs) were generated in the system without H + , but CDs with high PL intensity and QYs could be prepared after H + was introduced. Moreover, with the increase of H + concentration, the QYs of the prepared CDs increase subsequently, and the highest QY reaches up to 43%. The formation mechanism was explored, and the results showed that H + changes the surface groups of the CDs generated without H + into those that exist on the CDs generated with H + , which further improves the PL performance of the CDs. Different from most CDs reported in the literature, the as-prepared CDs can still exhibit high PL intensity even under strong acidic condition.

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One-step preparation of branched PEG functionalized AIE-active luminescent polymeric nanoprobes

Cited by 12 publications

References 58 publications

Hydrophobic Carbon Dots Derived from Organic Pollutants and Applications in NIR Anticounterfeiting and Bioimaging

Hydrophobic Carbon Dots Derived from Organic Pollutants and Applications in NIR Anticounterfeiting and Bioimaging

Mutually Synergistic Nanoparticles for Effective Thermo‐Molecularly Targeted Therapy

One-Step Synthesis of Acidophilic Highly-Photoluminescent Carbon Dots Modified by Ionic Liquid from Polyethylene Glycol

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