One-step preparation of hydrophilic carbon nanofiber containing magnetic Ni nanoparticles materials and their application in drug delivery

Wang, Chih-Jen; Chen, Tse–Ching; Lin, Jarrn-Horng; Huang, Peng; Tsai, Hsing-Jui; Chen, Ching-Shiun

doi:10.1016/j.jcis.2014.10.073

Cited by 36 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature [30,39,40] shows that the pH-dependent adsorption/release is mostly characterized by pseudo-second-order kinetic model, whereas the that does not seem to be the governing release mechanism in the present study [38].…”

Section: Discussionmentioning

confidence: 55%

Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride

Jassal

Sengupta

Bhowmick

2015

Journal of Biomaterials Science, Polymer Edition

View full text Add to dashboard Cite

Functionalized electrospun polymer fibers are a promising candidate for controlled delivery of chemotherapeutic drugs to improve the therapeutic efficacy and to reduce the potential toxic effects by delivering the drug at a rate governed by the physiological need of the site of action. In this study, poly(caprolactone) (PCL) fibers were fabricated by electrospinning, followed by hydrolyzation to introduce functional groups on the fiber surface. Characterization studies were performed on these functionalized fibers using X-ray photoelectron spectroscopy, scanning electron microscopy, and Toluidine Blue O dye assay. The pH-sensitivity of the functional groups on the fiber surface and doxorubicin hydrochloride was utilized to bind the drug electrostatically to these functionalized PCL fibers. The effect of pH on drug loading and release kinetics was investigated. Results indicate successful electrostatic binding of the drug to functionalized electrospun fibers and a high drug payload. The drug delivery response can be modulated by introduction of suitable stimuli (pH).

show abstract

Section: Discussionmentioning

confidence: 55%

Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride

Jassal

Sengupta

Bhowmick

2015

Journal of Biomaterials Science, Polymer Edition

View full text Add to dashboard Cite

show abstract

“…The spinneret consists of two main units: the rotor (8), which fits into a stationary housing, i.e. stator (7). At the bottom a copper slide bushing (9) connects them, maintaining concentric position during the rotation.…”

Section: The Invented Electrospinning Processmentioning

confidence: 99%

“…Electrospinning is a popular method in research for generating nanofibers, since these can have applications in various sensor & engineering [1,2], biomedical [3][4][5] and pharmaceutical [6][7][8], etc.…”

Section: Introductionmentioning

confidence: 99%

Shear-aided annular needleless electrospinning

Molnár¹

2019

Mater. Res. Express

View full text Add to dashboard Cite

We briefly introduce a new approach for electrospinning in this paper. The novel high-speed electrospinning setup we invented involves a spinneret consisting of a cylindrical rotor placed within a concentric stator, both having a sharp metal edge. The solution gets out of the spinneret at the annular orifice in between these two edges forming a narrow liquid meniscus from which electrospinning jets are initiated. The setup applies mechanical shearing on the electrospinning solution. As the shear rate is increased (via the rotation speed) the viscosity of the shear-thinning solution decreases leading to enhanced Taylor-cone formation and the initiation of multiple jets. The throughput can be several orders of magnitude higher than that of the single capillary method and seems to be limited mainly by the evaporation rate of the solvent. With the small spinneret we reached 20 ml/h throughput for poly(ethyle oxide) solutions. The average fiber diameters decreased from 297 nm to 202 nm by applying shearing within the annulus.

show abstract

“…Recently, graphene and its derivatives have attracted an overwhelming interest for potential medical or biological applications such as biosensors, cellular imaging, and drug delivery [1][2][3][4][5][6][7][8][9] . Graphene based nanomaterials possess large specific surface areas (theoretical value ~ 2630 m 2 g -1 ) [2,10] and are able to complex with aromatic drugs via π-π stacking and/or hydrophobic interaction [11,12] for excellent drug storage property [13] .…”

Section: Introductionmentioning

confidence: 99%

Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide

Zheng

Xiao

2016

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Targeted drug delivery has become important, attractive and challenging in biomedical science and applications. Anti-HER2 antibody-conjugated poly-l-lysine functionalized reduced graphene oxide (anti-HER2-rGO-PLL) nanocarriers were prepared to efficiently deliver doxorubicin targeting at the nucleus of HER2 over-expressing cancer cells. The polycationic PLL was first covalently grafted to graphene oxide (GO) nanosheets followed by reduction to obtain rGO-PLL with high drug loading and good colloidal stability. The anti-HER2 antibodies were subsequently conjugated to the amino groups of PLL to achieve excellent cell uptake capability. Cellular uptake of anti-HER2-rGO-PLL into MCF7/HER2 cells is significantly higher than that of rGO-PLL due to the specific targeting of anti-HER2 to HER2 overexpressing breast cancer cells. Additionally the anti-HER2-rGO-PLL enables a fast accumulation of DOX inside the nucleus, its subcellular site of action. In vitro cytotoxicity measurements clearly reveal a seven fold improvement in the anticancer efficacy for anti-HER2-rGO-PLL/DOX in comparison to rGO-PLL/DOX. The enhanced anticancer efficacy could be ascribed to the different intracellular DOX distributions resulted from the different internalization routes that are energy-dependent macropinocytosis and energy-independent direct penetration by anti-HER2-rGO-PLL and rGO-PLL, respectively. The results demonstrate that anti-HER2 conjugated rGO-PLL developed is a promising vehicle for efficient nuclear delivery of chemotherapeutic agents to HER2 over-expressing tumours.

show abstract

One-step preparation of hydrophilic carbon nanofiber containing magnetic Ni nanoparticles materials and their application in drug delivery

Cited by 36 publications

References 37 publications

Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride

Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride

Shear-aided annular needleless electrospinning

Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide

Contact Info

Product

Resources

About