One-step preparation of multifunctional alginate microspheres loaded with <i>in situ</i>-formed gold nanostars as a photothermal agent

Hou, Fangli; Zhu, Yanhong; Zou, Qian; Zhang, Chun; Wang, Hong; Liao, Yonggui; Wang, Qin; Yang, Xiangliang; Yang, Yajiang

doi:10.1039/c9qm00276f

Cited by 15 publications

(5 citation statements)

References 48 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A solution of paraffin oil and calcium chloride with a concentration of 0.8% CaCl 2 was created using the emulsification-solvent evaporation technique outlined in [33]. Simultaneously, during the formation of droplets, the interfacial tension between the paraffin oil-sodium alginate phases is excessively high when conducting experiments without any surfactant.…”

Section: Methodsmentioning

confidence: 99%

Double-layer coated particles formed by one-step method based on microfluidic technology

Hu,

Chen,

Lin

et al. 2024

J. Micromech. Microeng.

View full text Add to dashboard Cite

This study used a microfluidic device with a focus-wrapping structure to create double-layer calcium alginate hydrogel drug particles in a one-step process. We validated the double-layer structure of the particles using both a fluorescence and regular light microscope. Curcumin and catalase were distributed independently in each layer, and we expected that such structure could play a role in the slow release of drugs. This scheme greatly reduces the need of hydrophilic and hydrophobic modification treatment, therefore greatly simplifies the experimental process. In the meantime, the requirement for injecting drugs into osteoarthritis and other diseases is expected to be realized, expanding the use of hydrogel in the medical field, because the microsphere is easy to generate, inexpensive, and strong in internal drug substitutability.

show abstract

Section: Methodsmentioning

confidence: 99%

Double-layer coated particles formed by one-step method based on microfluidic technology

Hu,

Chen,

Lin

et al. 2024

J. Micromech. Microeng.

View full text Add to dashboard Cite

show abstract

“…For most metal nanoparticles or metal oxide particles that are difficult to synthesize (such as Ta (Figure 6 A, ii) 93 and TaO x (Figure 6 A, iii) 103 nanoparticles), they can be encapsulated into the embolic matrix. For some nanoparticles that can be synthesized by precipitation or redox reactions (such as BaSO 4 (Figure 6 A, iv) 88 , 112 , Bi 2 S 3 124 , Au (Figure 6 A, ii) 125 ), they can be in situ generated within the embolic structure.…”

Section: Micro/nano Materials Used For Particulate Embolic Agentsmentioning

confidence: 99%

“…Its basic principle is to selectively embolize the hepatic tumor supply arteries with stimulus-responsive embolic agents, followed by external stimulation exposure to generate hysteretic heating of the embolized particles and hence the surrounding tissues 182 . For this purpose, micro/nano materials that are sensitive to external energy fields are often incorporated into the embolic matrices, such as magnetic-sensitive nanoparticles 171 , microwave-sensitive nanosheets 101 , HIFU-sensitive nanocapsules 120 , photothermal-sensitive nanostars 125 , and radiofrequency-sensitive nanoclusters 183 , etc. Besides, it can also realize active drug release via external energy regulation, which will enable a more flexible dosing regimen.…”

Section: Micro/nano Materials Used For Particulate Embolic Agentsmentioning

confidence: 99%

“…In order to further improve the therapeutic effect and simplify the repeated embolization step, the development of photothermal-sensitive embolic microspheres is meaningful. The basic strategy is similar to other stimulation-susceptible embolic agents introduced earlier, that is, the inclusion of photothermal conversion agents (such as gold 125 , iron oxide 206 , and bismuth 124 , 207 based nanoparticles) into the embolic matrix (Figure 8 D). For example, Huang et al synthesized photothermal-sensitive composite microspheres by an inverse emulsion copolymerization, in which polydopamine coated SPIO NPs (SPION@PDA) and doxorubicin were encapsulated (Figure 8 D, i) 206 .…”

Section: Micro/nano Materials Used For Particulate Embolic Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Bench-to-bedside development of multifunctional flexible embolic agents

Wang¹,

Rao²

2023

Theranostics

View full text Add to dashboard Cite

Transarterial chemoembolization (TACE) has been demonstrated to provide a survival benefit for patients with unresectable hepatocellular carcinoma (HCC). However, conventional TACE still faces limitations associated with complications, side effects, unsatisfactory tumor responses, repeated treatment, and narrow indications. For further improvement of TACE, additional beneficial functions such as degradability, drug-loading and releasing properties, detectability, targetability, and multiple therapeutic modalities were introduced. The purpose here is to provide a comprehensive overview of current and emerging particulate embolization technology with respect to materials. Therefore, this review systematically identified and described typical features, various functions, and practical applications of recently emerging micro/nano materials as particulate embolic agents for TACE. Besides, new insights into the liquid metals-based multifunctional and flexible embolic agents were highlighted. The current development routes and future outlooks of these micro/nano embolic materials were also presented to promote advancement in the field.

show abstract

“…The mechanism of the PTT is based on the principle that the photothermal agents absorb the NIR light converting into heat, leading to cancer cell ablation and death [2]. In this regard, gold nanomaterials, such as gold nanostructure (gold nanoparticles (AuNPs) [3][4][5], gold nanorods (AuNRs) [6][7][8][9], gold nanocages (AuNCs) [10][11][12], gold nanostars [13][14][15], gold nanoshell [16][17][18] and gold nanoflowers [19]) have been developed as photothermal agents for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Double Drug-Loaded and pH/Thermal Sensitive Multifunctional Drug Delivery System for Tumor Photoacoustic Imaging-Guided Enhanced Chemo/Photothermal Therapy

Wang

Chen²,

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Owing to the tunability of longitudinal surface plasmon resonance (LSPR), ease of synthesizing small size and excellent stability, AuNRs have been developed as photothermal agents for cancer therapy. However, PTT alone could not kill cancer cells completely due to the local heterogeneous distribution of heat in tumors, penetration depth of light, light scattering and absorption. In addition, the treatment systems based on AuNRs hold disadvantages of loading one antitumor drug or a low therapeutic efficiency. Therefore, the construction of the AuNRs theranostic system to achieve imaging-guided dual drug delivery and enhanced photothermal therapy for tumor still remains a great challenge.Methods: The AuNRs were prepared using a seedless method. A mesoporous silica shell layer was coated on the surface of the AuNRs by sol-gel method. Double anticancer drugs, DOX and Btz, were loaded into the AuNRs@MSN nanoparticles through physical absorption and covalent conjugation, respectively.Results: The release of DOX and Btz is found pH/thermal dual responsive in vitro. Compared with AuNRs@MSN, PDA-AuNRs@MSN exhibits an increased near-infrared (NIR) absorption at 808 nm and an enhanced photothermal effect. In contrast to chemotherapy or photothermal therapy alone, the integrated D/B-PDA-AuNRs@MSN nanoparticles show higher cell apoptosis and enhanced tumor treatment efficacy in vitro and in vivo.Conclusions: In this study, we designed a double-drug loading, enhanced chemo/photothermal therapy and pH/thermal responsive drug delivery system for photoacoustic (PA) imaging-guided tumor therapy. We believe that the multifunctional D/B-PDA-AuNRs@MSN theranostic probe could serve as an effective probe for the treatment of cancers.

show abstract

One-step preparation of multifunctional alginate microspheres loaded with in situ-formed gold nanostars as a photothermal agent

Abstract: Alginate microspheres with encapsulated gold nanostars integrating chemoembolization and NIR-induced hyperthermia have been prepared via a feasible method.

Cited by 15 publications

References 48 publications

Double-layer coated particles formed by one-step method based on microfluidic technology

Double-layer coated particles formed by one-step method based on microfluidic technology

Bench-to-bedside development of multifunctional flexible embolic agents

Double Drug-Loaded and pH/Thermal Sensitive Multifunctional Drug Delivery System for Tumor Photoacoustic Imaging-Guided Enhanced Chemo/Photothermal Therapy

Contact Info

Product

Resources

About