One step processing of aminofunctionalized gate oxides

Arroyo-Hernández, María; Manso‐Silván, Miguel; López-Elvira, Elena; Múñoz, A.; Climent, A.; Duart, José Manuel Martínez

doi:10.1016/j.bios.2006.10.039

Cited by 20 publications

(18 citation statements)

References 15 publications

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“…Figure 8(a) shows the differences in the FTIR spectra as chemical or thermal oxidation treatment is used for stabilizing PSi. The most intense band at 1050-1100 cm -1 corresponding to asymmetric stretching in SiO [27] is present both in CoxPSi and ToxPSi; however, the intensity of this band is weaker in CoxPSi. This means that ToxPSi is a harsher oxidation process than CoxPSi, as also evident from the disappearance of the SiH peak at 615 cm -1 in ToxPSi.…”

Section: Resultsmentioning

confidence: 94%

“…The as-prepared PSi has a characteristic band at 615 cm -1 referred to as SiH. After Cox, two bands appear at every step of surface modification: a strong band at 1050-1100 cm -1 , assigned to asymmetric stretching in SiO [27], and a weak band at 835-795 cm -1 from the Si-OH bond [28]. It is clear that Cox stabilization leads to mostly oxidized PSi.…”

Section: Resultsmentioning

confidence: 99%

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Chemical stabilization of porous silicon for enhanced biofunctionalization with immunoglobulin

Naveas

Costa

Gallach

et al. 2012

Science and Technology of Advanced Materials

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Porous silicon (PSi) is widely used in biological experiments, owing to its biocompatibility and well-established fabrication methods that allow tailoring its surface. Nevertheless, there are some unresolved issues such as deciding whether the stabilization of PSi is necessary for its biological applications and evaluating the effects of PSi stabilization on the surface biofunctionalization with proteins. In this work we demonstrate that non-stabilized PSi is prone to detachment owing to the stress induced upon biomolecular adsorption. Biofunctionalized non-stabilized PSi loses the interference properties characteristic of a thin film, and groove-like structures resulting from a final layer collapse were observed by scanning electron microscopy. Likewise, direct PSi derivatization with 3-aminopropyl-triethoxysilane (APTS) does not stabilize PSi against immunoglobulin biofunctionalization. To overcome this problem, we developed a simple chemical process of stabilizing PSi (CoxPSi) for biological applications, which has several advantages over thermal stabilization (ToxPSi). The process consists of chemical oxidation in H 2 O 2 , surface derivatization with APTS and a curing step at 120• C. This process offers integral homogeneous PSi morphology, hydrophilic surface termination (contact angle θ = 26• ) and highly efficient derivatized and biofunctionalized PSi surfaces (six times more efficient than ToxPSi). All these features are highly desirable for biological applications, such as biosensing, where our results can be used for the design and optimization of the biomolecular immobilization cascade on PSi surfaces.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Chemical stabilization of porous silicon for enhanced biofunctionalization with immunoglobulin

Naveas

Costa

Gallach

et al. 2012

Science and Technology of Advanced Materials

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show abstract

“…Infrared spectroscopy (IR) is another useful tool for the surface chemical modification studying, in particular, for SAM investigation [19][20][21]. The FT-IR spectrums for the SAMs used in this work are presented in Fig.…”

Section: Ft-ir Resultsmentioning

confidence: 99%

Electrochemical studies of self-assembled monolayers using impedance spectroscopy

Einati

Mottel

Inberg

et al. 2009

Electrochimica Acta

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“…There are fewer reports on silanization in the vapor phase. 9,20–25 Vapor-phase modification offers obvious advantages in eliminating solvent use and not having substrates in direct contact with silane solutions in terms of avoiding excess water 9 and direct depositions of silane oligomers/polymers onto substrates. Vapor-phase depositions generally result in smooth silane monolayers, 20–23 which are attractive for many applications.…”

Section: Introductionmentioning

confidence: 99%

How To Prepare Reproducible, Homogeneous, and Hydrolytically Stable Aminosilane-Derived Layers on Silica

2011

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Five functional silanes, 3-aminopropyltriethoxysilane (APTES), 3-aminopropyltrimethoxysilane (APTMS), N-(2-aminoethyl)-3-aminopropyltriethoxysilane (AEAPTES), and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS), and N-(6-aminohexyl)aminomethyltriethoxysilane (AHAMTES) were assessed for the preparation of hydrolytically stable amine-functionalized silica substrates. These can be categorized into three groups (G1, G2, and G3) based on the intra-molecular coordinating ability of the amine functionality to the silicon center. Silanizations were carried out in anhydrous toluene as well as in the vapor phase at elevated temperatures. Aminosilane-derived layers prepared in solution are multilayers in nature and those produced in the vapor phase have monolayer characteristics. In general, vapor-phase reactions are much less sensitive to variations in humidity and reagent purity, are more practical than solution-phase method, and generate more reproducible results. Intra-molecular catalysis by the amine functionality is found to be important for both silanizaton and hydrolysis. The primary amine group in the G1 silanes (APTES and APTMS) can readily catalyze siloxane bond formation and hydrolysis to render their silane layers unstable toward hydrolysis. The amine functionality in the G3 silane (AHAMTES) is incapable of intra-molecular catalysis of silanization so that stable siloxane bonds between the silane molecules and surface silanols do not form easily. The secondary amine group in the G2 silanes (AEAPTES and AEAPTMS), on the other hand, can catalyze siloxane bond formation, but the intra-molecular catalysis of bond detachment is sterically hindered. The G2 silanes are the best candidates for preparing stable amine-functionalized surfaces. Between the two G2 aminosilanes, AEAPTES results in more reproducible silane layers than AEAPTMS in the vapor phase due to its lower sensitivity to water content in the reaction systems.

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One step processing of aminofunctionalized gate oxides

Cited by 20 publications

References 15 publications

Chemical stabilization of porous silicon for enhanced biofunctionalization with immunoglobulin

Chemical stabilization of porous silicon for enhanced biofunctionalization with immunoglobulin

Electrochemical studies of self-assembled monolayers using impedance spectroscopy

How To Prepare Reproducible, Homogeneous, and Hydrolytically Stable Aminosilane-Derived Layers on Silica

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