One-step reduction of graphene oxide with l-glutathione

Pham, Tuan Anh; Kim, Jeong-Sik; Kim, Jeong Su; Jeong, Yeon Tae

doi:10.1016/j.colsurfa.2011.05.019

Cited by 178 publications

(69 citation statements)

References 29 publications

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“…FTIR spectra of GO are shown in Figure 3A. The FTIR spectra of the GO sample accorded well with previously published reports, [38][39][40] showing various oxygen configurations. An intense and broad peak appeared at around 3,440 cm -1 , assigned to the stretching mode of an O-H bond, revealed the abundance of hydroxyl groups in GO.…”

Section: Ftir Analysis Of Rgo-agnpssupporting

confidence: 75%

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Yuan¹,

Gurunathan²

2017

IJN

116

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Background Cisplatin (Cis) is a widely used chemotherapeutic drug for treating a variety of cancers, due to its ability to induce cell death in cancer cells significantly. Recently, graphene and its modified nanocomposites have gained much interest in cancer therapy, due to their unique physicochemical properties. The objective of this study was to investigate the combination effect of Cis and a reduced graphene oxide–silver nanoparticle nanocomposite (rGO-AgNPs) in human cervical cancer (HeLa) cells. Materials and methods We synthesized AgNPs, rGO, and rGO-AgNP nanocomposites using C-phycocyanin. The synthesized nanomaterials were characterized using various analytical techniques. The anticancer properties of the Cis, rGO-AgNPs, and combination of Cis and rGO-AgNPs were evaluated using a series of cellular assays, such as cell viability, cell proliferation, LDH leakage, reactive oxygen species generation, and cellular levels of oxidative and antioxidative stress markers such as malondialdehyde, glutathione, SOD, and CAT. The expression of proapoptotic, antiapoptotic, and autophagy genes were measured using real-time reverse-transcription polymerase chain reaction. Results The synthesized AgNPs were well dispersed, homogeneous, and spherical, with an average size of 10 nm and uniformly distributed on graphene sheets. Cis, GO, rGO, AgNPs, and rGO-AgNPs inhibited cell viability in a dose-dependent manner. The combination of Cis and rGO-AgNPs showed significant effects on cell proliferation, cytotoxicity, and apoptosis. The combination of Cis and rGO-AgNPs had more pronounced effects on the expression of apoptotic and autophagy genes, and also significantly induced the accumulation of autophagosomes and autophagolysosomes, which was associated with the generation of reactive oxygen species. Conclusion Our findings substantiated rGO-AgNPs strongly potentiating Cis-induced cytotoxicity, apoptosis, and autophagy in HeLa cells, and hence rGO-AgNPs could be potentially applied to cervical cancer treatment as a powerful synergistic agent with Cis or any other chemotherapeutic agents.

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Section: Ftir Analysis Of Rgo-agnpssupporting

confidence: 75%

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Yuan¹,

Gurunathan²

2017

IJN

116

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“…On the other hand, the strong sharp diffraction signal at 2% = 26.5°, corresponding to the reflection of graphene nanoplatelets' (002) crystal diffraction plane [24] (see insert in Figure 7), although is reduced with decreasing the concentration of nanoplatelets, does not fully disappear after foaming, indicating that there is no full exfoliation of the graphene nanoplatelets [1,14,15].…”

Section: Morphology and Structurementioning

confidence: 96%

Graphene nanoplatelets-reinforced polyetherimide foams prepared by water vapor-induced phase separation

Abbasi¹,

Antunes²,

Velasco³

2015

Express Polym. Lett.

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Abstract. The present work considers the preparation of medium-density polyetherimide foams reinforced with variable amounts of graphene nanoplatelets (1-10 wt%) by means of water vapor-induced phase separation (WVIPS) and their characterization . A homogeneous closed-cell structure with cell sizes around 10 µm was obtained, with foams exhibiting zero crystallinity according to X-ray diffraction (XRD). Thermogravimetric analysis under nitrogen showed a two-step thermal decomposition behaviour for both unfilled and graphene-reinforced foams, with foams containing graphene presenting thermal stability improvements, related to a physical barrier effect promoted by the nanoplatelets. Thermo-mechanical analysis indicated that the specific storage modulus of the nanocomposite foams significantly increased owing to the high stiffness of graphene and finer cellular morphology of the foams. Although foamed nanocomposites displayed no further sign of graphene nanoplatelets exfoliation, the electrical conductivity of these foams was significant even for low graphene contents, with a tunnel-like model fitting well to the evolution of the electrical conductivity with the amount of graphene.

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“…As seen, the equilibrium concentration 14 (C e , g L -1 ) and equilibrium adsorption capacity values (q e , mg g -1 ) were fitted by their linearized expressions [29][30][31][32][42][43][44]. Accordingly, the maximum adsorption capacity for GO and SRGO were calculated by the Langmuir equation, as follows:…”

Section: Adsorption Of Go-based Materialsmentioning

confidence: 99%

“…However, to date, chemically derived graphene oxide (GO) from graphite has revealed a variety of potential uses because of its flexibility and relatively cheap fabrication. Like a graphene precursor, a subsequent GO reduction could restore the sp 2 carbon structure via various methods such as annealing [4], solvothermal/hydrothermal processes [5][6][7], or different kinds of reductants [8][9][10][11][12][13][14][15]. However, compared to mechanical exfoliation, functionalities (as defects) can be meanwhile imperfectly introduced onto graphene sheet surfaces.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide adsorption enhanced by in situ reduction with sodium hydrosulfite to remove acridine orange from aqueous solution

Sun

Fugetsu

2012

Journal of Hazardous Materials

206

107

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Graphene oxide (GO) is a highly effective adsorbent, and its absorbing capability is further enhanced through its in situ reduction with sodium hydrosulfite as the reductant. Acridine orange is the selected target to eliminate with GO as the adsorbent.Under identical conditions, GO without the in situ reduction showed a maximum adsorption capacity of 1.4 g g -1 , and GO with the in situ reduction provided a maximum adsorption capacity of 3.3 g g -1 . Sodium hydrosulfite converts carbonyl groups on GO into hydroxyl groups, which function as the key sites for the adsorption enhancement.

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One-step reduction of graphene oxide with l-glutathione

Cited by 178 publications

References 29 publications

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Graphene nanoplatelets-reinforced polyetherimide foams prepared by water vapor-induced phase separation

Graphene oxide adsorption enhanced by in situ reduction with sodium hydrosulfite to remove acridine orange from aqueous solution

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One-step reduction of graphene oxide with l-glutathione

Cited by 178 publications

References 29 publications

Combination of graphene oxide&ndash;silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Combination of graphene oxide&ndash;silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Graphene nanoplatelets-reinforced polyetherimide foams prepared by water vapor-induced phase separation

Graphene oxide adsorption enhanced by in situ reduction with sodium hydrosulfite to remove acridine orange from aqueous solution

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Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells