One-Step Repair in Talar Osteochondral Lesions

Giannini, Sandro; Buda, Roberto; Battaglia, Milva; Cavallo, Marco; Ruffilli, Alberto; Ramponi, Laura; Pagliazzi, Gherardo; Vannini, Francesca

doi:10.1177/0363546512467622

Cited by 166 publications

(118 citation statements)

References 33 publications

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“…Histological evaluation was not performed in this comparative study. Nevertheless, the osteochondral regeneration of both techniques was confirmed by histological samples in previous papers [6,8,9,12,17].…”

Section: Discussionsupporting

confidence: 59%

“…The BMDCT procedure was performed as previously described in other papers [5,8,17]. The BMDCT procedure started the day before surgery, with platelet-rich fibrin (PRF) gel collection.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…ACI is still considered one of the most reliable procedures for OLT, while BMDCT was applied with satisfactory results at four-year follow-up [4,5,10,11,17]. However, no studies comparing the outcomes of the two techniques in similar lesions are currently available.…”

Section: Introductionmentioning

confidence: 99%

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Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

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Section: Discussionsupporting

confidence: 59%

“…The BMDCT procedure was performed as previously described in other papers [5,8,17]. The BMDCT procedure started the day before surgery, with platelet-rich fibrin (PRF) gel collection.…”

Section: Surgical Proceduresmentioning

confidence: 99%

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Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Buda

Vannini

Castagnini

et al. 2015

International Orthopaedics (SICOT)

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“…Repair tissue showed comparable T2 values to hyaline cartilage 2 years and 4 years after bone marrow derived cell transplantation at the talus [170, 171]. T2 differed significantly between the superficial and deep layers 9.5 years after Mfx, detected via 7 T MRI [141].…”

Section: Resultsmentioning

confidence: 99%

Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques?

Jungmann

Baum

Bauer

et al. 2014

BioMed Research International

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Background. New quantitative magnetic resonance imaging (MRI) techniques are increasingly applied as outcome measures after cartilage repair. Objective. To review the current literature on the use of quantitative MRI biomarkers for evaluation of cartilage repair at the knee and ankle. Methods. Using PubMed literature research, studies on biochemical, quantitative MR imaging of cartilage repair were identified and reviewed. Results. Quantitative MR biomarkers detect early degeneration of articular cartilage, mainly represented by an increasing water content, collagen disruption, and proteoglycan loss. Recently, feasibility of biochemical MR imaging of cartilage repair tissue and surrounding cartilage was demonstrated. Ultrastructural properties of the tissue after different repair procedures resulted in differences in imaging characteristics. T2 mapping, T1rho mapping, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), and diffusion weighted imaging (DWI) are applicable on most clinical 1.5 T and 3 T MR scanners. Currently, a standard of reference is difficult to define and knowledge is limited concerning correlation of clinical and MR findings. The lack of histological correlations complicates the identification of the exact tissue composition. Conclusions. A multimodal approach combining several quantitative MRI techniques in addition to morphological and clinical evaluation might be promising. Further investigations are required to demonstrate the potential for outcome evaluation after cartilage repair.

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“…Indeed, most of these studies underlined the benefits that the HA derivatives, either as hydrogel or solid mesh, exerted in human diseases such as venous ulcers [107],[108], decubitus ulcers [109], oral mucosal lesions [110], surgical ablation of nevi/cutaneous tumors and cicatritial outcomes [111], talar dome and knee osteochondral lesions [112],[113], and cranial bone regeneration [114]. So far, no clinical trial started to verify whether such biomaterial can be useful also to repair the infarcted myocardium.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan and cardiac regeneration

et al. 2014

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Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations. In the heart HA is involved in physiological functions, such as cardiac development during embryogenesis, and in pathological conditions including atherosclerosis and myocardial infarction. Moreover, owing to its relevant biological properties, HA has been widely used as a biomaterial for heart regeneration after a myocardial infarction. Indeed, HA and its derivatives are biodegradable and biocompatible, promote faster healing of injured tissues, and support cells in relevant processes including survival, proliferation, and differentiation. Injectable HA-based therapies for cardiovascular disease are gaining growing attention because of the benefits obtained in preclinical models of myocardial infarction. HA-based hydrogels, especially as a vehicle for stem cells, have been demonstrated to improve the process of cardiac repair by stimulating angiogenesis, reducing inflammation, and supporting local and grafted cells in their reparative functions. Solid-state HA-based scaffolds have been also investigated to produce constructs hosting mesenchymal stem cells or endothelial progenitor cells to be transplanted onto the infarcted surface of the heart. Finally, applying an ex-vivo mechanical stretching, stem cells grown in HA-based 3D scaffolds can further increase extracellular matrix production and proneness to differentiate into muscle phenotypes, thus suggesting a potential strategy to create a suitable engineered myocardial tissue for cardiac regeneration.Electronic supplementary materialThe online version of this article (doi:10.1186/s12929-014-0100-4) contains supplementary material, which is available to authorized users.

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One-Step Repair in Talar Osteochondral Lesions

Abstract: One-step repair of OLTs had good clinical results that were durable over time, even though there was a slight decrease in AOFAS score at the latest follow-up. The quality of the regenerated tissue detected by MRI T2 mapping directly correlated with the clinical results.

Cited by 166 publications

References 33 publications

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation

Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques?

Hyaluronan and cardiac regeneration

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