One step synthesis of 2-substituted 3-tri-(or di-)fluoromethyl-2-propenals in an ionic liquid

Kitazume, Tomoya; Nagura, Hirokatsu; Koguchi, Shinichi

doi:10.1016/j.jfluchem.2003.10.010

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Synthesis Of α-Functionally Substituted αβ-Unsaturated Aldehydes1

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2004

2021

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Cited by 8 publications

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“…In 2004, Kitazume et al [ 74 ] elaborated a one-stage synthesis of 2-substituted 3-tri-(or di-)-fluoromethyl-2-propenals using versatile aldehydes, tri- or di-fluoroacetaldehyde ethyl hemiacetal in the presence of diethylaminotrimethylsilane (DEATMS) in an ionic liquid. This protocol permits us to successfully construct 2-substituted propenals with high levels of selectivity of the geometric isomers ( Scheme 23 ).…”

Section: Synthesis Of α-Functionally Substituted αβ-Unsaturated Aldehydesmentioning

confidence: 99%

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

2021

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α-Functionalized α,β-unsaturated aldehydes is an important class of compounds, which are widely used in fine organic synthesis, biology, medicine and pharmacology, chemical industry, and agriculture. Some of the 2-substituted 2-alkenals are found to be the key metabolites in plant and animal cells. Therefore, the development of efficient methods for their synthesis attracts the attention of organic chemists. This review focusses on the recent advances in the synthesis of 2-functionally substituted 2-alkenals. The approaches to the preparation of α-alkyl α,β-unsaturated aldehydes are not included in this review.

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Section: Synthesis Of α-Functionally Substituted αβ-Unsaturated Aldehydesmentioning

confidence: 99%