One-step synthesis of carbon dots for selective bacterial inactivation and bacterial differentiation

Gao, Zhe; Yang, Dezhi; Yang, Wenjun; Yang, Yaling

doi:10.1007/s00216-019-02293-0

Cited by 31 publications

(33 citation statements)

References 47 publications

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“…The photosensitization effect for BrCND can be observed clearly in Figure 4 b, with increasing absorption values of BrCND corresponding to different dilutions of the samples [ 56 ]. In this case, no dark toxicity effects were observed for the concentration range of BrCND tested, as is common for other carbon dot photosensitization studies [ 3 , 16 , 17 , 19 , 22 , 49 , 51 , 55 ]. It must be noted, though, that it is not always true that carbon dots alone exhibit no toxicity to bacterial cells independent of a photosensitization mechanism [ 3 , 25 , 26 , 28 , 36 ].…”

Section: Carbon Nanodots As Photodynamic Antimicrobial Agentssupporting

confidence: 69%

“…Although the 10 h exposure interval shown here does in fact seem quite lengthy, the authors do additionally note a significant impairment of growth (monitored by OD590) after as little as 1 h exposure compared to the untreated control. Morphology changes have also been reported for Gram-positive bacteria treated with carbon dot photosensitizers including S. aureus [ 51 ].…”

Section: Carbon Nanodots As Photodynamic Antimicrobial Agentsmentioning

confidence: 96%

“…In fact, the structural, chemical, and photophysical characteristics of carbon dots imbue a strong versatility in their potential through tuning and modification. Accordingly, carbon dots are mentioned to have been employed for photocatalytic dye degradation [ 22 , 27 , 40 , 51 ], photocatalytic/electrical water splitting [ 22 , 52 ], solar devices [ 22 , 40 , 53 ], detection and biosensing [ 3 , 16 , 27 , 51 ], drug delivery [ 3 , 27 , 51 ], bioimaging [ 3 , 17 , 27 , 51 ], gene transmission [ 3 , 17 ], and even in LED technologies [ 27 , 54 ]—although this list is far from exhaustive and is ever-expanding, including APDT applications.…”

Section: Characterization Of Carbon Nanodots: An Overview Of Key Smentioning

confidence: 99%

“…It is intriguing to note also that in some cases, such as a 2018 study by Zhang et al [ 55 ], one Type I product is detected while the other is not (in their case, • OH was not detected by their methods). Type I products are in fact quite interconnected, potentially inter-converting rapidly as illustrated in the following reaction schematic [ 51 ]: CNDs + hv → e − + h + , O 2 + e − → O 2 •− , H 2 O + h + → H + + • OH, O 2 •− + H + → • O 2 H, H + + • O 2 H → H 2 O 2 , H 2 O 2 + e − → OH − + • OH, OH − + h + → • OH, …”

Section: Carbon Nanodots As Photodynamic Antimicrobial Agentsmentioning

confidence: 99%

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Carbon Nanodots in Photodynamic Antimicrobial Therapy: A Review

Knoblauch

Geddes

2020

Materials

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Antibiotic resistance development in bacteria is an ever-increasing global health concern as new resistant strains and/or resistance mechanisms emerge each day, out-pacing the discovery of novel antibiotics. Increasingly, research focuses on alternate techniques, such as antimicrobial photodynamic therapy (APDT) or photocatalytic disinfection, to combat pathogens even before infection occurs. Small molecule “photosensitizers” have been developed to date for this application, using light energy to inflict damage and death on nearby pathogens via the generation of reactive oxygen species (ROS). These molecular agents are frequently limited in widespread application by synthetic expense and complexity. Carbon dots, or fluorescent, quasi-spherical nanoparticle structures, provide an inexpensive and “green” solution for a new class of APDT photosensitizers. To date, reviews have examined the overall antimicrobial properties of carbon dot structures. Herein we provide a focused review on the recent progress for carbon nanodots in photodynamic disinfection, highlighting select studies of carbon dots as intrinsic photosensitizers, structural tuning strategies for optimization, and their use in hybrid disinfection systems and materials. Limitations and challenges are also discussed, and contemporary experimental strategies presented. This review provides a focused foundation for which APDT using carbon dots may be expanded in future research, ultimately on a global scale.

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Section: Carbon Nanodots As Photodynamic Antimicrobial Agentssupporting

confidence: 69%

Section: Carbon Nanodots As Photodynamic Antimicrobial Agentsmentioning

confidence: 96%

Section: Characterization Of Carbon Nanodots: An Overview Of Key Smentioning

confidence: 99%

Section: Carbon Nanodots As Photodynamic Antimicrobial Agentsmentioning

confidence: 99%

See 2 more Smart Citations

Carbon Nanodots in Photodynamic Antimicrobial Therapy: A Review

Knoblauch

Geddes

2020

Materials

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“…Interestingly, these strategies were exemplified by Sidhu et al, who achieved both the coating of standard citric acid-based CNPs with penicillin G, and the direct preparation of penicillin-based CNPs using the antibiotic as a carbon source [147] (Figure 11a), which made the NPs intrinsically hostile towards pathogens with and without light. The use of ampicillin as a carbon source in CNPs was also recently reported, and led to CNPs killing preferentially Gram+ bacteria with ROS generation under visible light irradiation [148]. In addition, by using appropriate building blocks, either in the core or on the surface, the ROS generation efficiency could be fine-tuned by Mandal et al, whose CNPs were derived from anthraquinone derivatives.…”

Section: Synthetic and Other Bio-inspired Polymer Conjugatesmentioning

confidence: 94%

Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy

2020

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Photodynamic inactivation of microorganisms has gained substantial attention due to its unique mode of action, in which pathogens are unable to generate resistance, and due to the fact that it can be applied in a minimally invasive manner. In photodynamic therapy (PDT), a non-toxic photosensitizer (PS) is activated by a specific wavelength of light and generates highly cytotoxic reactive oxygen species (ROS) such as superoxide (O2−, type-I mechanism) or singlet oxygen (1O2*, type-II mechanism). Although it offers many advantages over conventional treatment methods, ROS-mediated microbial killing is often faced with the issues of accessibility, poor selectivity and off-target damage. Thus, several strategies have been employed to develop target-specific antimicrobial PDT (aPDT). This includes conjugation of known PS building-blocks to either non-specific cationic moieties or target-specific antibiotics and antimicrobial peptides, or combining them with targeting nanomaterials. In this review, we summarise these general strategies and related challenges, and highlight recent developments in targeted aPDT.

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Antibacterial Carbon Dots: Mechanisms, Design, and Applications

Zhao

Liu

Wang

et al. 2023

Adv Healthcare Materials

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The increase in antibiotic resistance promotes the situation of developing new antibiotics at the forefront, while the development of non‐antibiotic pharmaceuticals is equally significant. In the post‐antibiotic era, nanomaterials with high antibacterial efficiency and no drug resistance make them attractive candidates for antibacterial materials. Carbon dots (CDs), as a kind of carbon‐based zero‐dimensional nanomaterial, are attracting much attention for their multifunctional properties. The abundant surface states, tunable photoexcited states, and excellent photo‐electron transfer properties make sterilization of CDs feasible and are gradually emerging in the antibacterial field. This review provides comprehensive insights into the recent development of CDs in the antibacterial field. The topics include mechanisms, design, and optimization processes, and their potential practical applications are also highlighted, such as treatment of bacterial infections, against bacterial biofilms, antibacterial surfaces, food preservation, and bacteria imaging and detection. Meanwhile, the challenges and outlook of CDs in the antibacterial field are discussed and proposed.

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One-step synthesis of carbon dots for selective bacterial inactivation and bacterial differentiation

Cited by 31 publications

References 47 publications

Carbon Nanodots in Photodynamic Antimicrobial Therapy: A Review

Carbon Nanodots in Photodynamic Antimicrobial Therapy: A Review

Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy

Antibacterial Carbon Dots: Mechanisms, Design, and Applications

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