One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

Abstract

Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe3O4 and γ-Fe2O3). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biologically active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphology, structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and physical properties. The specificity of the chemical bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

“…Weak ferromagnetic properties prevent particles from clumping together, ensuring they remain uniformly dispersed out in the desired location, which promotes cellular absorption and drugs delivery. Bioactive nanosystems based on the synthesized magnetic composites (HA-Fe x O y ) with adsorbed biologically active substances have been developed for potential in vivo applications, particularly in the field of bone disease treatment [ 122 ].…”

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

“…Regarding shape, the reinforcing materials for CaPO 4 include particles [941,942], platelets [943,944], whiskers [580,664,[945][946][947], and fibers [948][949][950][951][952], regarding their sizes, they can be of nano-(Section 5.3 above), micro-, and macro-dimensions, and certainly they can be of diverse chemical composition. Namely, zirconia and PSZ [931][932][933][934]945,[953][954][955][956][957][958][959][960][961], magnesia [962], alumina [941,944,[963][964][965][966], alumina + magnesia [967], titania [968][969][970][971], alumina + titania [972], iron oxides [973][974][975][976] (Figure 9), other oxides and mixtures thereof ...…”

“…Namely, zirconia and PSZ [931][932][933][934]945,[953][954][955][956][957][958][959][960][961], magnesia [962], alumina [941,944,[963][964][965][966], alumina + magnesia [967], titania [968][969][970][971], alumina + titania [972], iron oxides [973][974][975][976] (Figure 9), other oxides and mixtures thereof [947,[977][978][979][980][981][982], silica and/or glass [983][984][985][986][987][988][989][990][991][9...…”