One-step synthesis of photoluminescent carbon dots with excitation-independent emission for selective bioimaging and gene delivery

Yang, Xudong; Wang, Yang; Shen, Xiran; Su, Chunyan; Yang, Jinghua; Piao, Mingjun; Jia, Fei; Gao, Guanghui; Zhang, Long; Lin, Quan

doi:10.1016/j.jcis.2016.12.057

Cited by 121 publications

(53 citation statements)

References 51 publications

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“…introduced this phenomenon could come from the synergy effect dopants such as nitrogen and sulfur, which also helped enhance the QY of CDs . As for the PL mechanism, Lin and his co‐workers mentioned in another paper that CDs exhibiting excitation wavelength‐independent PL reflects surface states rather than size effect, and the surface states should be rather uniform . Such CDs are often reported to have solvent effect but with relatively low quantum yield ,.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent Carbon Dots: A Mixture of Heterogeneous Fractions

et al. 2018

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Photoluminescent carbon dots (CDs) fractions have been isolated from a gel-like material (GM), which was synthesized using a convenient one-step solvothermal route. In terms of purification, size exclusion chromatography (SEC) and dialysis were compared with acetone wash, which revealed the advantage of acetone wash. The pre-purified GM with acetone wash (A-GM) was further isolated by the reversed-phase preparative thin layer chromatography (TLC) with acetonitrile-water mixture (7 : 3; v /v ) as the developing solvent. As a result, there were four photoluminescent bands on the TLC plate, which indicated the presence of four photoluminescent fractions. Detailed characterization measurements such as UV/Vis absorption, fluorescence emission, attenuated total reflection Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, zeta potential, dynamic light scattering, atomic force microscopy, and TEM measurements were performed on all fractions to analyze their heterogeneous optical, structural, electrical, and morphological properties. Considering the comprehensive analysis, all isolated fractions were CDs. In addition, excitation wavelength-independent CDs were obtained with a mean size of 2.5 nm and high quantum yield (55 %). Furthermore, the study demonstrates that the excitation wavelength-dependent photoluminescence of GM could result from the mixture of different surface states of each CD fraction rather than multiple surface states of uniform CDs nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Photoluminescent Carbon Dots: A Mixture of Heterogeneous Fractions

et al. 2018

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“…A smart carrier was developed for redox-responsive controlled drug delivery by grafting carboxyl-abundant carbon dots to the surface of silica nanoparticles which was found to be pH-dependent (Jiao et al 2016); doxorubicin loaded on the grafted silica had high drug loading (up to 13.1%) and showed a high cellular uptake and an excellent therapeutic effect on cancer cells by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Additionally, gene delivery has been successfully illustrated with positively charged carbon dots which could be linked to plasmid DNA and efficiently transfect the therapeutic plasmid into cells with high efficiency and low cytotoxicity (Yang et al 2017b). It has been shown that hyaluronate and polyethylenimine-functionalized carbon dots were internalized readily into the cytoplasm of cancer via hyaluronate-receptormediated endocytosis; the functionalized carbon dots have excellent gene condensation compatibility via electrostatic attraction and protective capacity by preventing nuclease degradation ).…”

Section: Drug and Gene Delivery Systemsmentioning

confidence: 99%

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

2020

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Carbon and graphene quantum dots are prepared using top-down and bottom-up methods. Sustainable synthesis of quantum dots has several advantages such as the use of low-cost and non-toxic raw materials, simple operations, expeditious reactions, renewable resources and straightforward post-processing steps. These nanomaterials are promising for clinical and biomedical sciences, especially in bioimaging, diagnosis, bioanalytical assays and biosensors. Here we review green methods for the fabrication of quantum dots, and biomedical and biotechnological applications.

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“…They are composed of sp 2 =sp 3 -hybridized carbon atoms, have various surface functional groups, and possess composition-dependent fluorescence. This relatively new material has attracted huge interest in many fields including, but not limited to, electrocatalysis [6], biosensing [7][8][9][10], bioimaging [11][12][13][14], chemical sensing [15], and nanomedicine [16], due to their unique tunable photoluminescence (PL) properties, chemical inertness, high water solubility, ease and low cost of fabrication and, more importantly, low toxicity. Additionally, CQDs have also attracted considerable interest in various photocatalytic applications-environmental remediation [17][18][19][20][21], water splitting to produce H 2 production [22][23][24][25][26][27], CO 2 conversion [28][29][30], and synthesis of chemicals [28][29][30][31][32][33]-because when coupled with a semiconductor photocatalyst, CQDs can provide with several advantages, including improved light harvesting ability, efficient usage of the full spectrum of sunlight, efficient charge carrier separation, stability, and hinder charge recombination.…”

Section: Introductionmentioning

confidence: 99%

CQD-Based Composites as Visible-Light Active Photocatalysts for Purification of Water

Makama¹,

Umar²,

AbdulkadirSaidu³

2018

Visible-Light Photocatalysis of Carbon-Based Materials

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The unique physicochemical properties of carbon quantum dot-(CQD)-based photocatalysts, notably their exceptionally good light absorption in the UV and near-visible region, tunable photoluminescence, extraordinary upconversion photoluminescence, outstanding electron affinity, and photoinduced electron transfer, and electron mobility, have attracted considerable attention in different photocatalytic applications. In this review, we summarized the fundamental mechanism and thermodynamics of heterogeneous photocatalysis of aqueous pollutants and the fundamental multifaceted roles of CQDs in photoredox process. Furthermore, we discussed the recent developments in the use of CQD-based materials as visiblelight active photocatalysts in water purification. Finally, the challenges and future direction of CQD-based materials as photocatalytic materials for environmental decontamination were highlighted.

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One-step synthesis of photoluminescent carbon dots with excitation-independent emission for selective bioimaging and gene delivery

Cited by 121 publications

References 51 publications

Photoluminescent Carbon Dots: A Mixture of Heterogeneous Fractions

Photoluminescent Carbon Dots: A Mixture of Heterogeneous Fractions

Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review

CQD-Based Composites as Visible-Light Active Photocatalysts for Purification of Water

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