One-Step Synthesis of Pyridine Derivatives from Malononitrile with Bisarylidenecycloalkanone under Microwave Irradiation

Abstract

Six pyridine derivatives were synthesised by one-step reaction of malononitrile with 2,5-bisarylidenecyclopentanones or 2,6-bisarylidenecyclohexanones in methanol / sodium hydroxide under microwave irradiation in 75~92% yields.

Synthesis, biological activities, and future perspectives of steroidal monocyclic pyridines

“…One procedure for the synthesis of pyridine derivatives is from the reactions of unsaturated ketones with active methylene compounds. 66 The reactions might proceed through a Michael addition reaction, followed by a cyclization reaction. Amr et al 67 reported a versatile and efficient procedure for the synthesis of pyridosteroids utilizing the reactivity of steroids with an unsaturated ketone core in their reactions with various reagents.…”

“…One procedure for the synthesis of pyridine derivatives is from the reactions of unsaturated ketones with active methylene compounds. 66 The reactions might proceed through a Michael addition reaction, followed by a cyclization reaction. Amr et al 67 Moffat oxidation is a chemical reaction for the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively.…”

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

“…The montmorillonite clay contains both acidic and basic sites, and behaves as a ditopic catalyst that allows for the direct formation of 292. The same synthetic strategy was employed to construct substituted 4 Η − pyran derivatives by condensation of α,β-unsaturated ketones with activated methylene compounds such as malononitrile [421].…”

Efficient Synthesis of 6,7-Dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile Compounds and Their Applicability As Inhibitor Films for Steel Alloy Corrosion: Collective Computational and Practical Approaches

“… 17 The pyridine moiety is more attractive because of its widespread chemical applications. 18 , 19 For example, 3-cyanopyridine derivatives have many uses, such as IKKb inhibitors and A2A adenosine receptor antagonists. 20 Recently, several protocols have been reported to produce 3-cyanopyridine derivatives.…”

“…Heterocyclic components containing nitrogen are seemingly the essential component in the structure of numerous novel designs and the synthesis of organic components and they naturally exist as alkaloid compounds, which are vital for use as medicinal drug compounds . The pyridine moiety is more attractive because of its widespread chemical applications. , For example, 3-cyanopyridine derivatives have many uses, such as IKKb inhibitors and A2A adenosine receptor antagonists . Recently, several protocols have been reported to produce 3-cyanopyridine derivatives.…”