One-Step Synthesis of Versatile Antimicrobial Nano-Architected Implant Coatings for Hard and Soft Tissue Healing

Abstract

Dental implant failure remains a prevalent problem around the globe. The integration of implants at the interface of soft and hard tissues is complex and susceptible to instability and infections. Modifications to the surface of titanium implants have been developed to improve the performance, yet insufficient integration and biofilm formation remain major problems. Introducing nanostructures on the surface to augment the implant–tissue contact holds promise for facilitated implant integration; however, current coating processes are limited in their versatility or costs. We present a highly modular single-step approach to produce multicomponent porous bioactive nanostructured coatings on implants. Inorganic nanoparticle building blocks with complex compositions and architectures are synthesized in situ and deposited on the implants in a single step using scalable liquid-feed flame spray pyrolysis. We present hybrid coatings based on ceria and bioglass, which render the implant surfaces superhydrophilic, promote cell adhesion, and exhibit antimicrobial properties. By modifications to the bioglass/ceria nanohybrid composition and architecture that prevent biomineralization, the coating can instead be tailored toward soft tissue healing. The one-step synthesis of nano-architected tissue-specific coatings has great potential in dental implantology and beyond.

Titanium Nanobowl-Based Nest-Like Nanofiber Structure Prepared at Room Temperature and Pressure Promotes Osseointegration of Beagle Implants

“…Dental implantation, one of the most effective methods of repairing oral dentition defects and dentition loss, restores the morphology and function of patients’ oral and maxillofacial systems ( Elani et al, 2018 ; Guglielmotti et al, 2019 ). Medical pure titanium has become the preferred material for artificial implants because of its metal properties, corrosion resistance, biocompatibility, and bone-bonding properties ( Marin et al, 2013 ; Shubin Wang et al, 2020 ; Matter et al, 2021 ). There is usually no direct contact between the titanium implant and the bone, although a layer of fiber tissue is formed, which leads to poor osseointegration and implant failure ( Xia et al, 2018 ).…”

Advanced materials and technologies for oral diseases

“…(f) One-step synthesis of versatile antimicrobial nano-architected implant coatings for hard and soft tissue healing. Reproduced by permission from [ 210 ], copyright 2021, American Chemical Society. (g) Optical and scanning electron microscopy (SEM) images of different implant types studied.…”

“…For example, a scalable liquid-feed flame spray pyrolysis (LF-FSP) technique was used to construct a one-step synthetic nanostructured tissue-specific coating ( Figure 7(f) ). The coating is composed of CeO NPs and BG, and the composition of the material can be adjusted to achieve different soft and hard tissue healing patterns, thus giving individualized implants to different patients [ 210 ]. In addition, modification of graphene nanoparticles to the rough surface of the implant increases the hydrophilic properties of the implant surface, and graphene has good biocompatibility.…”

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

“…Recently, Matter et al developed a triple-functional implant surface, which possessed antimicrobial, osteogenic, and soft tissue integration properties ( Matter et al, 2021 ). Bioactive glass, cerium dioxide nanoparticles, and 2% of zinc doping were used to create the intriguing nanocoating.…”