One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens

Zhou, Chengcheng; Jiang, Meijuan; Du, Jian; Bai, Haotian; Shan, Guo‐Gang; Kwok, Ryan T. K.; Chau, Joseph Lik Hang; Zhang, Jun; Lam, Jacky W. Y.; Huang, Peng; Tang, Ben Zhong

doi:10.1039/d0sc00256a

Cited by 72 publications

(57 citation statements)

References 59 publications

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“…Some specific AIEgens have been developed for the detection of fungi. [ 165,166 ] For example, Tang et al. fabricated a microenvironment‐sensitive AIEgen IQ‐Cm for visual fast discrimination of Gram‐negative bacteria, Gram‐positive bacteria, and fungi ( Figure ).…”

Section: Aiegens For Theranostic Treatment Of Fungimentioning

confidence: 99%

“…fabricated a microenvironment‐sensitive AIEgen IQ‐Cm for visual fast discrimination of Gram‐negative bacteria, Gram‐positive bacteria, and fungi ( Figure ). [ 166 ] The Gram‐negative bacteria E. coli possess double‐layered cell wall structure, which can restrict the entry to cytoplasm. In this situation, IQ‐Cm mainly binds with the membrane of E. coli with green emission.…”

Section: Aiegens For Theranostic Treatment Of Fungimentioning

confidence: 99%

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Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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The prevention and control of pathogenic bacteria, fungi, and viruses is a herculean task for all the countries since they greatly threaten global public health. Rapid detection and effective elimination of these pathogens is crucial for the treatment of related diseases. It is urgently demanded to develop new diagnostic and therapeutic strategies to combat bacteria, fungi, and viruses‐induced infections. The emergence of aggregation‐induced emission (AIE) luminogens (AIEgens) is a revolutionary breakthrough for the treatment of many diseases, including pathogenic infections. In this review, the main focus is on the applications of AIEgens for theranostic treatment of pathogenic bacteria, fungi, and viruses. Due to the AIE characteristic, AIEgens are promising fluorescent probes for the detection of bacteria, fungi, and viruses with excellent sensitivity and photostability. Moreover, AIEgen‐based theranostic platforms can be fabricated by introducing bactericidal moieties or designing AIE photosensitizers and AIE photothermal agents. The current strategies and ongoing developments of AIEgens for the treatment of pathogenic bacteria, fungi, and viruses will be discussed in detail.

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Section: Aiegens For Theranostic Treatment Of Fungimentioning

confidence: 99%

Section: Aiegens For Theranostic Treatment Of Fungimentioning

confidence: 99%

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Chen

Han

Tang

et al. 2021

Adv Healthcare Materials

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“…So far, several AIEgens coupled with bacteria recognition groups such as positively charged groups, along with antibiotics, boric acid, carbohydrates, and so on (Table 2), have been reported to image and eliminate pathogens on the basis of various binding interactions with bacteria. Most bacteria contain large amounts of anionic phospholipids, making their surfaces negatively charged and thus allowing positively charged Anionic phospholipids [25] Anionic phospholipids [32] Anionic phospholipids [40] Anionic phospholipids [39b]…”

Section: Aiegens Capable Of Bacterial Imaging and Ablationmentioning

confidence: 99%

AIEgens for Bacterial Imaging and Ablation

Borjihan

Dong

et al. 2021

Adv Healthcare Materials

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Accurate and sensitive diagnosis of pathogenic bacterial infection is a fundamental first step for correct bacteria management, helping to avoid the development of drug-resistant bacteria caused by the inappropriate use and overuse of antibiotics. Fluorescence probes as a promising visual tool can help identify pathogens rapidly and reliably. However, rigidly structured traditional fluorescence probes generally suffer from the drawback of aggregation-caused quenching (ACQ) effect, which greatly undermines their advantages with respect to sensitivity. Luminogens with aggregation-induced emission properties, namely AIEgens, can overcome the ACQ effect and certain AIEgen-based materials are capable of generating reactive oxygen species (ROS) in the aggregate states. Hence, they have become powerful tools for imaging and killing bacteria. This review summarizes the recent advances in AIEgens for the diagnosis and treatment of pathogen infections. Special attention has been paid to the molecular design, the application in bacterial imaging and ablation in vitro and in vivo, and the biocompatibility of AIEgens. Finally, the challenges and prospects are discussed in terms of using AIEgens to advance precision therapies for pathogen infections.

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“…In general, on account of their adverse hydrophobicity and ACQ nature to the imaging and PDT effects, most of reported NPs strategies are still unsuitable for traditional Ir(III) complexes 70 . Currently, ionic groups have attracted great interest in the biological field due to their unique water solubility, satisfying stability, low dark toxicity, and high cellular internalization under physiological conditions 71,72 . The preparation method of NPs by one‐step ion exchange is simple, feasible, and and give high yield.…”

Section: Improve Biocompatibility Strategiesmentioning

confidence: 99%

Recent advances of transition Ir(III) complexes as photosensitizers for improved photodynamic therapy

Zhang

2021

VIEW

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Photodynamic therapy (PDT), a minimally invasive procedure, usually required photosensitizer (PS) under light irradiation to convert the absorbed light energy into reactive oxygen species (ROS) to cause cancer cell apoptosis. The PSs with abundant excited triplet state play a critical role to guarantee the PDT effect. Transition Ir(III) complexes has been proved to be an effective PSs for PDT, owing to their high intersystem crossing (ISC) ability, tunable optical properties, long excited state lifetimes. However, poor biocompatibility, short excitation wavelength, and high oxygen dependence limit their biomedical applications. This review summarizes important progress of Ir(III) complexes as PS in improved PDT, including: (1) the strategy of nanoparticles is employed to improve their biocompatibility, and significantly enhance the cellular intracellular efficiency at the same time. (2) Their excitation wavelength is successfully extended by combining fluorophores, forming nanoscale Metal‐Organic frameworks (nMOFs) or two‐photon excited therapy. (3) Their therapeutic effect for antihypoxic tumors is enhanced by constructing mitochondrial‐targeted PS or type I PDT. In addition, simple modification of the precursor is beneficial to obtain a more excellent therapeutic effect. Finally, we brief summarize the current challenges and future research opportunities for Ir(III) complexes in this research field.

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One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens

Abstract: A simple AIEgen with three emission colors achieves rapid identification of Gram-negative bacteria, Gram-positive bacteria and fungi.

Cited by 72 publications

References 59 publications

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

AIEgens for Bacterial Imaging and Ablation

Recent advances of transition Ir(III) complexes as photosensitizers for improved photodynamic therapy

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