One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

Li, Yinglei; Wang, Junfeng; He, Wei; Lin, Xiuping; Zhou, Xin; Liu, Yonghong

doi:10.1007/s10600-017-1994-3

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…et al, 2014), five cytochalasins ( 138 – 142 ) (Wang et al, 2015b), and three alkaloids ( 143 – 145 ) when cultivated in a rotary liquid medium (Wang et al, 2015c). However, only phenethyl 5-hydroxy-4-oxohexanoate ( 146 ) was traced in rice medium (Li Y. L. et al, 2017). Bioassay suggested that compounds 143 – 146 possessed in vitro cytotoxicity against cancer cell lines A549, BGC823, Huh-7, K562, H1975, MCF-7, HL60, U937, Hela, and MOLT-4 with IC 50 values in range of 0.24–45 μM.…”

Section: Cultivation Conditionmentioning

confidence: 99%

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

et al. 2019

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Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents.

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Section: Cultivation Conditionmentioning

confidence: 99%

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

et al. 2019

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“…Until now, about twenty 4-hydroxy-2-pyridone alkaloids with a decalin ring have been reported and showed significant cytotoxicity, antimicrobial activity and AChE inhibitory activity, but only arthpyrones A–C were isolated from marine-derived fungus [ 6 , 14 , 15 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Our current study contributed eight new members ( 1 – 8 ) to this structural class from a deep-sea-derived fungus Arthrinium sp.…”

Section: Discussionmentioning

confidence: 99%

“…Marine fungi have been considered to be an invaluable resource for bioactive compounds and play an important role in the search for novel antimicrobial compounds [ 1 , 2 , 3 ]. Fungi of the genus Arthrinium are widely distributed throughout the world and have proven to produce diverse secondary metabolites with a variety of bioactivities, including cytotoxicity [ 4 , 5 , 6 , 7 ], antimicrobial [ 8 ], anti-HSV [ 9 ], AChE inhibitory [ 4 ], COX-2 inhibitory [ 10 ], syncytium formation inhibitory [ 11 ] and Maxi-K channel modulatory [ 12 ] activities, as well as lethality against brine shrimp [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008

et al. 2018

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Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D–K (1–8), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2-c]pyridin-3(2H)-one motif. Compounds 3–6 and 9 exhibited moderate to significant antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 values ranging from 1.66–42.8 μM, while 9 displayed cytotoxicity against two human osteosarcoma cell lines (U2OS and MG63) with IC50 values of 19.3 and 11.7 μM, respectively.

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“…For instance, cytotoxic cytochalasins, pyridone alkaloids and polyketides, along with naphthalene glycosides with COX-2 inhibitory activity, were obtained from the sponge-derived fungus A . arundinis ZSDS1-F3 [ 6 , 7 , 8 , 9 ]; arundifungin with antifungal property was isolated from another A . arundinis species [ 10 ]; griseofulvin derivatives showing lethality against the brine shrimp Artemia salina were reported from a gorgonian-derived Arthrinium fungus [ 11 ]; antiangiogenic diterpenes were discovered from the marine species A .…”

Section: Introductionmentioning

confidence: 99%

New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

Bao

et al. 2018

Molecules

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Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.

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One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

Cited by 12 publications

References 13 publications

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008

New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

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