One Thing after Another: Ecthyma Gangrenosum

Khoo, Teresa; Ford, Florence; Lobo, Zeena; Psevdos, George

doi:10.1016/j.amjmed.2017.12.038

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…[1] Other bacterial etiologies, including Escherichia coli, S aureus, Aeromonas hydrophila, and Mucor species, were detected in 29 (17.4%) cases. [4][5][6] Bacteremia is relatively common in cases of P aeruginosa infection, but rare in cases of infection with other bacterial species. [1] It was difficult to make a diagnosis in our on the first day of admission; the initial diagnosis was tick bite infection with cellulitis because there was no indication of leukemia, such as blasts on the blood smear.…”

Section: Discussionmentioning

confidence: 99%

“…In a detailed analysis of 167 EG cases, 123 (73.6%) cases were associated with P aeruginosa infection [1] . Other bacterial etiologies, including Escherichia coli , S aureus , Aeromonas hydrophila , and Mucor species, were detected in 29 (17.4%) cases [4–6] . Bacteremia is relatively common in cases of P aeruginosa infection, but rare in cases of infection with other bacterial species [1] .…”

Section: Discussionmentioning

confidence: 99%

“…Ecthyma gangrenosum (EG) is an uncommon cutaneous infection usually associated with Pseudomonas aeruginosa bacteremia in immunocompromised patients, particularly those with underlying malignant diseases [1,2] . Despite its rarity, especially in immunocompetent or nondiagnosed immunodeficiency patients, EG can present as the first manifestation of an underlying immunosuppression [3–6] . Here, we have reported a case of acute promyelocytic leukaemia (APL) presenting with EG as the first manifestation.…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] Despite its rarity, especially in immunocompetent or nondiagnosed immunodeficiency patients, EG can present as the first manifestation of an underlying immunosuppression. [3][4][5][6] Here, we have reported a case of acute promyelocytic leukaemia (APL) presenting with EG as the first manifestation.…”

Section: Introductionmentioning

confidence: 99%

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Acute myeloid leukaemia presenting with ecthyma gangrenosum as the first manifestation

Hadano

Yoshida-Sakai²,

Imamura³

et al. 2021

Medicine

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Rationale Ecthyma gangrenosum (EG) is an uncommon cutaneous infection usually associated with Pseudomonas aeruginosa bacteremia in immunocompromised patients, particularly those with underlying malignant diseases. Despite its rarity, especially in immunocompetent or nondiagnosed immunodeficiency patients, EG can present as the first manifestation of an underlying immunosuppression. Patient concerns A 42-year-old Japanese man was admitted to our hospital with a 3-day history of a painless red macule on his right forearm and fever. Diagnoses Blood culture on admission revealed the presence of Pseudomonas aeruginosa , whereas pus culture of the skin lesion showed Pseudomonas aeruginosa and methicillin-susceptible Staphylococcus aureus positivity. Interventions Additional bone marrow aspirate examination and immunophenotyping were performed to confirm the diagnosis of acute promyelocytic leukaemia with PML-retinoic acid alpha receptor. Outcomes The patient was successfully treated with a 14-day course of antibiotics, and no evidence of relapse was noted. The patient achieved complete remission after treatment for acute promyelocytic leukaemia. Lessons It should be kept in mind that EG is an important cutaneous infection that is typically associated with P aeruginosa bacteremia and the presence of underlying immunodeficiency, such as acute leukaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute myeloid leukaemia presenting with ecthyma gangrenosum as the first manifestation

Hadano

Yoshida-Sakai²,

Imamura³

et al. 2021

Medicine

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“…Ecthyma gangrenosum (EG) is a cutaneous infection most commonly associated with Pseudomonas bacteremia and usually occurring in immunocompromised patients [1]. The infection progresses sequentially from a maculopapular rash to hemorrhagic bullae, then to necrotic ulcerations with surrounding erythema [2].…”

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confidence: 99%

Ecthyma gangrenosum in a patient with febrile pancytopenia

Mrabat¹,

Baybay²,

Dassouly³

et al. 2022

Our Dermatol Online

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Ecthyma gangrenosum (EG) is a cutaneous infection most commonly associated with Pseudomonas bacteremia and usually occurring in immunocompromised patients [1]. The infection progresses sequentially from a maculopapular rash to hemorrhagic bullae, then to necrotic ulcerations with surrounding erythema [2]. Herein, we report a case of ecthyma gangrenosum in an immunologically compromised patient. A 65-year-old female was admitted to the oncohematology department for febrile pancytopenia. Blood work revealed severe thrombocytopenia at 15,000/mm³), an absolute neutrophil count of 180 cells/mm³, and anemia. A sternal bone marrow puncture found 15% of plasma cells. Four days after the admission, the patient had a painful, quickly extending lesion on the abdomen. She described erythema that progressed to pustules, then ulcerations. On general clinical evaluation, the patient was feverish at 40°C. A dermatological examination revealed the presence of a 6 cm purpuric patch on the left flank with a central necrotic eschar (Fig. 1). The diagnosis of ecthyma gangrenosum was reached and the patient was treated with ceftazidime and vancomycin. Unfortunately, having gone into septic shock, the patient died one week later.

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2018

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One Thing after Another: Ecthyma Gangrenosum

Cited by 3 publications

References 7 publications

Acute myeloid leukaemia presenting with ecthyma gangrenosum as the first manifestation

Acute myeloid leukaemia presenting with ecthyma gangrenosum as the first manifestation

Ecthyma gangrenosum in a patient with febrile pancytopenia

Prednisone

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