One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

Francis, Arul Prakash; Ganapathy, Selvam; Palla, Venkata Rajsekhar; Murthy, P. Balakrishna; Ramaprabhu, Sundara; Devasena, T

doi:10.1016/j.toxrep.2015.02.003

Cited by 23 publications

(13 citation statements)

References 33 publications

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“…Pulmonary exposure to multiwalled carbon nanotubes (MWCNTs) results in lung inflammation, pulmonary fibrosis, and lung adenocarcinoma promotion as well as extrapulmonary transport to many areas of the body [[9], [10], [11], [12], [13], [14], [15], [16]]. MWCNT-induced inflammation and extrapulmonary transport have numerous effects in vivo, including cardiovascular effects, increased oxidative stress, reduced cognitive abilities in rats, and disruption of the reproductive cycle in female mice [3,15,[17], [18], [19], [20]].…”

Section: Introductionmentioning

confidence: 99%

Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure

et al. 2019

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“…Further, a chronic inhalation study has linked MWCNTs (Mitsui 7s) with fibrosis in rodents (Fukushima et al, in preparation). Studies have shown that the potential for inhaled MWCNTs to induce fibrosis is influenced by their physicochemical properties (Ma-Hock et al 2009 ; Mishra et al 2012 ; Sargent et al 2014 ; Francis et al 2015 ). Fibrosis is therefore an important and relevant end point to consider for the risk assessment of MWCNT.…”

Section: Fibrosis Induction By Mwcnts: An End Point Relevant To Assesmentioning

confidence: 99%

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

Clippinger¹,

Ahluwalia

Allen

et al. 2016

Arch Toxicol

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The increasing use of multi-walled carbon nanotubes (MWCNTs) in consumer products and their potential to induce adverse lung effects following inhalation has lead to much interest in better understanding the hazard associated with these nanomaterials (NMs). While the current regulatory requirement for substances of concern, such as MWCNTs, in many jurisdictions is a 90-day rodent inhalation test, the monetary, ethical, and scientific concerns associated with this test led an international expert group to convene in Washington, DC, USA, to discuss alternative approaches to evaluate the inhalation toxicity of MWCNTs. Pulmonary fibrosis was identified as a key adverse outcome linked to MWCNT exposure, and recommendations were made on the design of an in vitro assay that is predictive of the fibrotic potential of MWCNTs. While fibrosis takes weeks or months to develop in vivo, an in vitro test system may more rapidly predict fibrogenic potential by monitoring pro-fibrotic mediators (e.g., cytokines and growth factors). Therefore, the workshop discussions focused on the necessary specifications related to the development and evaluation of such an in vitro system. Recommendations were made for designing a system using lung-relevant cells co-cultured at the air–liquid interface to assess the pro-fibrogenic potential of aerosolized MWCNTs, while considering human-relevant dosimetry and NM life cycle transformations. The workshop discussions provided the fundamental design components of an air–liquid interface in vitro test system that will be subsequently expanded to the development of an alternative testing strategy to predict pulmonary toxicity and to generate data that will enable effective risk assessment of NMs.

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“…The most widely used techniques for the synthesis of carbon nanotubes (CNTs) are laser furnace, chemical vapor deposition, and arc discharge [31]. Their biomedical applications include biosensors, orthopedic prostheses, anticancer therapy, and tissue engineering [32]. The literature reports reveal that maternal exposure of CNTs might develop developmental toxicity such as teratogenicity [33].…”

Section: Introductionmentioning

confidence: 99%

“…The literature reports reveal that maternal exposure of CNTs might develop developmental toxicity such as teratogenicity [33]. The threat of nanotoxicity of CNTs is an increasing trend, as the global production of CNTs reaches several thousand tons per year [32]. Based on morphology, the carbon nanotube is generally classified into the two viz.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the agglomerates of SWCNTs caused granulomas in the proximal alveoli, and dispersed SWCNTs instigated interstitial fibrosis in the distal alveoli [43]. Similar to asbestos, MWCNTs have been reported to possess pathogenicity, owing to their larger durability and needle-like shape [32]. They found a wide variety of industrial applications in rechargeable batteries, water filters and sporting goods [44].…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of Zero- and One-Dimensional Carbon Nanomaterials

et al. 2019

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The zero (0-D) and one-dimensional (1-D) carbon nanomaterials have gained attention among researchers because they exhibit a larger surface area to volume ratio, and a smaller size. Furthermore, carbon is ubiquitously present in all living organisms. However, toxicity is a major concern while utilizing carbon nanomaterials for biomedical applications such as drug delivery, biosensing, and tissue regeneration. In the present review, we have summarized some of the recent findings of cellular and animal level toxicity studies of 0-D (carbon quantum dot, graphene quantum dot, nanodiamond, and carbon black) and 1-D (single-walled and multi-walled carbon nanotubes) carbon nanomaterials. The in vitro toxicity of carbon nanomaterials was exemplified in normal and cancer cell lines including fibroblasts, osteoblasts, macrophages, epithelial and endothelial cells of different sources. Similarly, the in vivo studies were illustrated in several animal species such as rats, mice, zebrafish, planktons and, guinea pigs, at various concentrations, route of administrations and exposure of nanoparticles. In addition, we have described the unique properties and commercial usage, as well as the similarities and differences among the nanoparticles. The aim of the current review is not only to signify the importance of studying the toxicity of 0-D and 1-D carbon nanomaterials, but also to emphasize the perspectives, future challenges and possible directions in the field.

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One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats

Cited by 23 publications

References 33 publications

Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure

Differential gene regulation in human small airway epithelial cells grown in monoculture versus coculture with human microvascular endothelial cells following multiwalled carbon nanotube exposure

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

Toxicity of Zero- and One-Dimensional Carbon Nanomaterials

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