One-Trial Memory for Object-Place Associations after Separate Lesions of Hippocampus and Posterior Parahippocampal Region in the Monkey

Málková, Ludiše; Mishkin, Mortimer

doi:10.1523/jneurosci.23-05-01956.2003

Cited by 231 publications

(177 citation statements)

References 62 publications

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“…This temporal profile suggests that perirhinal and other visual cortical regions can maintain visual memories accurately during intermediate spans and that the effects of perirhinal damage cannot be attributed solely to the disruption of signals going to and coming from the hippocampus. It also indicates that hippocampal deficits may be more difficult to detect in DMTS tasks that do not generate good, long delay performance (10,11,30).…”

Section: Discussionmentioning

confidence: 99%

“…The role of the hippocampus in this form of memory, on the other hand, cannot be as clearly inferred from existing data. For example, hippocampal damage in humans impairs performance on nonverbal recognition tasks, but the results in nonhuman primates are conflicting as to whether selective hippocampal damage impairs performance on visual recognition memory tasks (9)(10)(11)(12).…”

mentioning

confidence: 99%

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Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Prusky

Douglas

Nelson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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Visual recognition memory is subserved by a distributed set of neural circuits, which include structures of the temporal lobe. Conflicting experimental results regarding the role of the hippocampus in nonspatial forms of such memories have been attributed to species, task, and lesion discrepancies. We have overcome obstacles that have prevented a direct evaluation of the role of the hippocampus in this type of memory by developing for rats a nonspatial, picture-based, trial-unique, delayed matching-to-sample task that is a procedural analogue of standard visual recognition memory tasks used in primates. With this task, we demonstrate that rats have a visual memory profile, which is analogous to that in primates and depends on the function of perirhinal cortex. We also find that selective lesions of hippocampus impair delay-dependent visual memory with a profile different from that produced by damage to the perirhinal cortex. These data demonstrate that rats have a visual recognition memory system fundamentally similar to primates that depends on the function of the hippocampus.M ost theories of medial temporal lobe function are in agreement that the hippocampus and perirhinal cortex are important for learning and memory. The specific processes that depend on the hippocampus, however, have been the subject of intense debate: in general, agreement exists that hippocampal function is essential for spatial memory, but wide disagreement occurs on the role of the hippocampus in nonspatial, visual recognition memory, or more generally, in explicit or episodic memory (1-5).The hallmark of this type of memory is retrieval of specific information from a single event (or episode) (6, 7). Trial-unique, delayed, matching-to-sample (DMTS) and delayed, nonmatching-to-sample (DNMTS) tasks, in which the participant must choose between two or more items, one of which is an item seen only once previously, have become the standard for measuring recognition memory in humans and nonhuman primates. Studies in primates have clearly shown that damage to perirhinal cortex disrupts performance on these tasks (8). The role of the hippocampus in this form of memory, on the other hand, cannot be as clearly inferred from existing data. For example, hippocampal damage in humans impairs performance on nonverbal recognition tasks, but the results in nonhuman primates are conflicting as to whether selective hippocampal damage impairs performance on visual recognition memory tasks (9-12).Visual recognition memory tasks have had limited application in rodents, but in general, recognition memory has been found to be unaffected by hippocampal damage unless the memory task includes a spatial component (13)(14)(15). A striking example of the apparent spatial dependence of hippocampal function is found in a study by Dudchenko and colleagues (16), in which memory for places or odors was measured in DNMTS procedures. The memory for places, but not odors, was disrupted by selective damage to the hippocampus. Attempts to measure nonspatial visual recognitio...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Prusky

Douglas

Nelson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…The converse results were observed in the postrhinal cortex, that is, a response to spatial rearrangement but not to changing objects. In addition, while object recognition is impaired following perirhinal damage, object-location recognition is deficient following postrhinal damage in rats (Gaffan et al, 2004) and monkeys (Malkova and Mishkin, 2003;Alvarado and Bachevalier, 2005). Similarly, Norman and Eacott (2005) reported data suggesting that perirhinal lesions led to greater memory impairment for object pairings, whereas postrhinal lesions led to greater impairment in memory for the spatial context in which an object was presented.…”

Section: Parahippocampal/postrhinal Cortex and Mecmentioning

confidence: 98%

Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas

2008

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ABSTRACT:Whereas substantial recent evidence has suggested to some that the medial entorhinal cortex (MEC) plays a specialized role in spatial navigation, here we present evidence consistent with a broader role of the MEC in memory. A consideration of evidence on the anatomy and functional roles of medial temporal cortical areas and the hippocampus, and evidence from recordings from MEC neurons in rats performing a spatial memory task, suggest that the MEC may process information about both spatial and temporal context in support of episodic memory. V

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“…It was hypothesized that the D 1 -like antagonist SCH23390 would impair performance on the SOSS task, which is a more complex spatial working memory task. It was further predicted that the D 2 -selective antagonist raclopride would preferentially impair performance on the vsPAL task due to previous reports of a loss of D 2 expression in inferior temporal regions (Joyce et al 1998) which have been associated with object-in-place memory in monkeys (Malkova and Mishkin 2003), and findings of impaired memory after and D 2 -like antagonists (Arnsten et al 1995;Mehta et al 2001). Effects on PR, RTT and BMS tasks are predicted to be similar for the two compounds on the basis of prior results with drug-or food-reinforced responding (Nader et al 2002;Woolverton and Virus 1989) and motor function assays in monkeys.…”

Section: Introductionmentioning

confidence: 99%

Differential contributions of dopaminergic D1- and D2-like receptors to cognitive function in rhesus monkeys

et al. 2006

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Rationale-Dopaminergic neurotransmission is critically involved in many aspects of complex behavior and cognition beyond reward/reinforcement and motor function. Mental and behavioral disorders associated with major disruptions of dopamine neurotransmission, including schizophrenia, Attention Deficit/Hyperactivity Disorder, Parkinson's Disease, Huntington's Disease and substance abuse, produce constellations of neuropsychological deficits in learning, memory and attention in addition to other defining symptoms.Objective-To delineate the role dopaminergic D 1 -like and D 2 -like receptor subtypes play in complex brain functions.Methods-Monkeys (N=6) were trained on cognitive tests adapted from a human neuropsychological assessment battery (CANTAB; CAmbridge Neuropsychological Test Automated Battery). The battery included tests of spatial working memory (self-ordered spatial search task, SOSS), visuo-spatial associative memory and learning (visuo-spatial paired associates learning task, vsPAL) and motivation (progressive ratio task, PR). Tests of motor function (bimanual motor skill task, BMS; rotating turntable task, RTT) were also included. Effects of the dopamine D 2 -like antagonist raclopride (10-56 μg/kg, i.m.) and the D 1 -like antagonist SCH23390 (SCH; 3.2-56 μg/kg, i.m.) on cognitive performance were then determined.Results-Deficits on PR, RTT and BMS performance were observed after both raclopride and SCH23390. Spatial working memory accuracy was reduced to a greater extent by raclopride than by SCH which was unexpected, given prior reports on the involvement of D1 signaling for spatial working memory in monkeys. Deficits were observed on vsPAL performance after raclopride, but not after SCH23390. Conclusions-The intriguing results suggest a greater contribution of D 2 -like over D 1 -like receptors to both spatial working memory and object-location associative memory.

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One-Trial Memory for Object-Place Associations after Separate Lesions of Hippocampus and Posterior Parahippocampal Region in the Monkey

Cited by 231 publications

References 62 publications

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas

Differential contributions of dopaminergic D1- and D2-like receptors to cognitive function in rhesus monkeys

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