We bring together in one place some of the main results and applications from our recent work on quantum information theory, in which we have brought techniques from operator theory, operator algebras, and graph theory for the first time to investigate the topic of distinguishability of sets of quantum states in quantum communication, with particular reference to the framework of one-way local quantum operations and classical communication (LOCC). We also derive a new graph-theoretic description of distinguishability in the case of a single-qubit sender.