One year changes in QCT and DXA bone densities following bariatric surgery in a multiethnic Asian cohort

Tan, Hong Chang; Tan, Margaret; Tham, Kwang Wei; Pasupathy, Shanker; Eng, Alvin; Ganguly, Sonali; Lai, Oi Fah; Ng, Alvin Choong Meng

doi:10.1016/j.afos.2015.08.001

Cited by 12 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inconformity of this result might be due to the different follow-up time. As for the lumbar spine (LS) BMD, all studies found comparable results between GB and SG groups [25,27,[33][34][35]. Though we found no significant difference in BMD with the presence of differences in other indicators mentioned above, we believe this result could be explained.…”

Section: Discussioncontrasting

confidence: 44%

“…Nevertheless, after analysis, we concluded that obese patients were more likely to suffer from secondary hyperparathyroidism after GB than after SG, although this issue requires more high-quality clinical studies for further confirmation. Carrasco et al concluded that femoral neck (FN) BMD decreased more profoundly after GB (follow-up of 24 months) [34], while other related studies reported similar results in terms of FN BMD between two groups (follow-up of 12 months) [25,33]. The inconformity of this result might be due to the different follow-up time.…”

Section: Discussionmentioning

confidence: 94%

“…Two reviewers then excluded 238 articles after screening titles and abstracts independently, and 41 articles were assessed for eligibility. Ultimately, 13 studies [24][25][26][27][28][29][30][31][32][33][34][35][36] were selected for inclusion.…”

Section: Literature Searchmentioning

confidence: 99%

See 2 more Smart Citations

Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis

Tian

Fan

et al. 2019

OBES SURG

View full text Add to dashboard Cite

Background Gastric bypass (GB) and sleeve gastrectomy (SG) are two common types of bariatric surgery that carry many potential complications. Among these complications, bone metabolism-related diseases have attracted substantial attention; however, no meta-analysis of them has been performed to date. Methods We searched PubMed, Web of Science, The Cochrane Library, and Embase to identify relevant studies published before January 2019. The following indicators were evaluated: serum parathyroid hormone (PTH), calcium, phosphorus and 25hydroxyvitamin D levels, body mass index (BMI), and bone mineral density (BMD). Results Thirteen studies met our inclusion criteria. Overall results showed that patients undergoing GB had lower levels of 25hydroxyvitamin D (MD = − 1.85, 95% CI (− 3.32, − 0.39) P = 0.01) and calcium (MD = − 0.15, 95% CI (− 0.24, − 0.07) P = 0.0006) as well as higher levels of PTH (MD = 3.58, 95% CI (0.61, 7.09) P = 0.02) and phosphorus (MD = 0.22, 95% CI (0.10, 0.35) P = 0.0005). The results of BMI and BMD were comparable in each group. Conclusion Our meta-analysis suggested that obese patients undergoing GB had lower levels of serum calcium and 25hydroxyvitamin D as well as higher levels of serum phosphorus and PTH. To prevent postoperative bone metabolism-related diseases, appropriate postoperative interventions should be undertaken for particular surgical procedures.

show abstract

Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis

Tian

Fan

et al. 2019

OBES SURG

View full text Add to dashboard Cite

show abstract

“…First, there is a high risk of selection bias due to the lack of randomization in all but 2 small studies ( 20 , 22 ). Second, there might also be a lack of statistical power due to the small sample size, with 6 studies having less than 50 participants ( 12 , 14 , 15 , 19 , 20 , 22 ). Third, type 2 diabetes is, despite having an increased risk of fragility fractures, associated with a higher BMD and lower bone turnover markers ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg)

Hofsø

Hillestad

Halvorsen

et al. 2020

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health. Objective To compare changes in bone mineral density and markers of bone turnover one year after SG and RYGB. Design, Setting, Patients, and Interventions Randomized, triple-blind, single-center trial at a tertiary care center in Norway. Primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB. Main Outcome Measures Changes in areal bone mineral density (aBMD) and bone turnover markers. Results Femoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n=44) than after SG (n=48) [mean (95% CI) between group differences -2.8 % (-0.8 to -4.7), -3.0 % (-0.9 to -5.0), -4.2 % (-2.1 to -6.4), and -0.5 % (0.6 to -1.6), respectively]. The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG, (both time x group, P<0.001). The changes in femoral neck, total hip and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P<0.05) and not weight change. Conclusions RYGB was associated with greater reduction in aBMD and greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.

show abstract

“…For example, when comparing SG to RYGB, achieved weight loss is less robust (9), with fewer nutrient deficiencies (10) and less pronounced increases in bone turnover (11,12,13). In the past decade, over a dozen studies have reported on change in BMD following SG using DXA (12,14,15,16,17,18,19,20,21,22,23,24), with primary design features and findings reported in Table 1. Six-, 12-, and 24-month percent change in total hip and lumbar spine BMD are also depicted graphically in Fig.…”

Section: Sleeve Gastrectomy and Bone Lossmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Bone complications of bariatric surgery: updates on sleeve gastrectomy, fractures, and interventions

Beavers

Greene

2020

European Journal of Endocrinology

View full text Add to dashboard Cite

Despite well recognized improvements in obesity-related comorbidities, increasing evidence implicates bariatric surgery in the onset of adverse skeletal health outcomes. The purpose of this review is to provide a focused update in three critical areas: 1) emergent data on sleeve gastrectomy and bone loss, 2) evidence linking bariatric surgery to incident fracture, and 3) intervention strategies designed to mitigate surgical bone loss. Better understanding of these issues will inform our treatment of skeletal health for patients planning bariatric surgery.

show abstract

One year changes in QCT and DXA bone densities following bariatric surgery in a multiethnic Asian cohort

Cited by 12 publications

References 31 publications

Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis

Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis

Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg)

MANAGEMENT OF ENDOCRINE DISEASE: Bone complications of bariatric surgery: updates on sleeve gastrectomy, fractures, and interventions

Contact Info

Product

Resources

About