One‐Year Changes in Symptoms of Depression and Weight in Overweight/Obese Individuals With Type 2 Diabetes in the Look AHEAD Study

Faulconbridge, Lucy F.; Wadden, Thomas A.; Rubin, Richard R.; Wing, Rena R.; Walkup, Michael P.; Fabricatore, Anthony N.; Coday, Mathilda; Dorsten, Brent Van; Mount, David L.; Ewing, Linda J.

doi:10.1038/oby.2011.315

Cited by 96 publications

(86 citation statements)

References 38 publications

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“…The author of this study (M.K.) had different attitudes than those of Faulconbridge et al [14] but partly the same opinions as Wild [16].…”

Section: Strength and Weakness In Relation To Other Studies And A Discontrasting

confidence: 44%

“…In their study, increased appetite, increased weight and tiredness were lower in obese patients than in the non-obese population. Faulconbridge et al [14] discovered that due to fears of a mood disorder, depressive individuals are excluded more often from weight loss trials. Similarly, depressive participants most likely will not lose weight to a satisfactory degree.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Depression and Severe Obesity: A Case-Control Study

Koski¹,

Naukkarinen²

2017

OJPsych

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Objectives: This study investigated the relationship between depression and obesity in severely obese retired individuals using the case-control method. Methods: The subject group consisted of 112 individuals receiving a permanent disability pension primarily due to obesity. The prevalence of depression was measured with a personal psychiatric interview and the Beck Depression Inventory (21). Male and female controls were selected separately, with five controls for male subjects and three controls for female subjects. The controls were matched with the subjects according to place of residence, age, time that pension was granted, and occupation. The statistical analyses included χ 2 tests, means, t-tests for paired variables, a conditional logistic linear model, correlation coefficients and the percent distributions. Results: Depression was diagnosed more often in the subject group than in the control group according to the psychiatric interview. Based on the conditional logistic linear model, individuals with severe obesity had a higher risk of depression than those in the control group. The most common disturbance was chronic depression in both groups. Additionally, there were significant findings regarding the outcome of depression for every classification in the psychiatric interview. According to the Beck Depression Inventory, depression was more common in subjects than in controls. However, slight depression was most common in the study group. Seven percent of the subjects had masked depression. The questions on the Beck Depression Inventory that measure irritability, indecisiveness, body image and ability to work were nearly significant. Regarding weight changes, the Beck Depression Inventory questions on both weight loss (p = 0.014) and weight gain (p = 0.017) were statistically significant. In the study group, individuals with BMI over 40 kg/m 2 gained the most weight; however, weight loss was very low overall. Regarding changes in appetite, the majority of the study group responded that they had a poorer appetite than previously. Conclusion:

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“…The author of this study (M.K.) had different attitudes than those of Faulconbridge et al [14] but partly the same opinions as Wild [16].…”

Section: Strength and Weakness In Relation To Other Studies And A Discontrasting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

The Relationship between Depression and Severe Obesity: A Case-Control Study

Koski¹,

Naukkarinen²

2017

OJPsych

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“…Severity of depressive symptoms at baseline did not influence the magnitude of weight lost (Faulconbridge et al, 2012). Obese females diagnosed with major depressive disorder receiving weekly group behavioural weight management for 16 weeks, combined with cognitive behaviour therapy (CBT) for depression, lost 11.4% of their initial weight and, compared to a non-depressed sample, depressed, obese individuals achieved similar weight loss following participation in a behavioural weight loss treatment (Linde et al, 2011).…”

Section: Accepted M Manuscriptmentioning

confidence: 95%

“…In a study by Faulconbridge et al (2012), overweight patients suffering from depression and type 2 diabetes lost 8.6% of their initial weight after a one year intensive…”

Section: Is Weight Loss Possible In Psychiatric Patients?mentioning

confidence: 99%

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Lopresti

Drummond

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

196

128

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Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations is reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined.

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“…Indeed, data from randomized controlled trials of structured group weight-loss interventions indicate that, on average, 80% of patients who enrol in such programmes go on to complete the treatment (Wadden & Butryn, 2003), with completers achieving a mean weight loss of 8e10% of their initial body weight within roughly 30 weeks (Wadden & Butryn, 2003). According to the 2013 Guidelines for the Management of Overweight and Obesity in Adults (Jensen et al, 2014), this amount of weight loss can be considered successful (i.e., in line with a 5e10% reduction of initial weight), being associated with a significant reduction in the incidence of type-2 diabetes (Knowler et al, 2002), and clinical improvements in weightrelated medical comorbidities (e.g., sleep apnoea, diabetes, hypertension, hyperlipidaemia) (Jensen et al, 2014), and psychosocial outcomes (e.g., mood, quality of life, and body image) (Dalle Grave et al, 2007;Faulconbridge et al, 2012;Fontaine, Barofsky, Bartlett, Franckowiak, & Andersen, 2004).…”

Section: Introductionmentioning

confidence: 97%