One-year follow-up of platelet-rich plasma to treat chronic upper patellar tendinopathies

Kaux, Jean‐François; Croisier, Jean-Louis; Bruyère, Olivier; Rohr, N; Goff, Caroline Le; Crielaard, Jean-Michel

doi:10.1016/j.rehab.2014.03.997

Cited by 22 publications

(47 citation statements)

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“…As performed in our previous study 18 , 1 year after infiltration, patients were contacted by phone by 111 the same examiner to fill out a standardized questionnaire on the pain severity and the return to 112 sports activities: 113 -pain during daily, professional and sports activities; 114 -the type of sport they practiced (the same or not as before tendinopathy); 115 -the level of sport they practiced (the same or not as before tendinopathy). 116…”

Section: Materials and Methods: 78mentioning

confidence: 99%

“…Interestingly, one study 69 demonstrated that PRP leads to a better clinical improvement than ESWT after 1 year 17 . Although it 70 is possible that a single infiltration is efficient in this indication 15,18 , most studies have, surprisingly, 71 evaluated the effects of multiple (n=2 or 3) successive infiltrations 13,14,17 . However, the 72 multiplication of infiltrations can reasonably be expected to increase the risks of complications (i.e.…”

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confidence: 99%

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Using platelet-rich plasma to treat jumper's knees: Exploring the effect of a second closely-timed infiltration

Kaux¹,

Croisier

Forthomme

et al. 2016

Journal of Science and Medicine in Sport

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Section: Materials and Methods: 78mentioning

confidence: 99%

mentioning

confidence: 99%

Using platelet-rich plasma to treat jumper's knees: Exploring the effect of a second closely-timed infiltration

Kaux¹,

Croisier

Forthomme

et al. 2016

Journal of Science and Medicine in Sport

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“…reports [8][9][10]. Briefly, the platelets are extracted using an apheresis machine (TEC.COM, Fresenius Kabi) which can lead to a reproducible platelet concentration of 850 000 units/microlitre, a value approximatively 4 times as high as in the whole blood [11].…”

Section: Are There Biologic Factors Of Good Prognosis After a Platelementioning

confidence: 99%

Are There Biologic Factors of Good Prognosis after a Platelet Rich Plasma (PRP) Injection for Tendinopathies ?

Libertiaux

Sancerne²,

Goff

et al. 2016

JESO

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Open Access Short communicationof extrinsinc factors include unadapted material, bad training planification, or usage of some drugs (quinolones, corticoids,…) [4]. Some patients are refractory to the traditional treatments (including physiotherapy, shockwaves, deep transverse massage, etc.) and thus need another option. Less invasive than surgery, Platelet-Rich Plasma (PRP) injection has become more and more popular over the last decades, particularly in sports medicine [5][6][7]. In this paper, in addition of presenting the data asserting the effectiveness of injections of reproducible PRP collected from an apheresis machine on different tendinopathies, we introduce another original contribution : the investigation of the possible correlation between several biomarkers and healing evolution to determine the factors of good prognosis, if any. Material and MethodsForty-eight patients (mean age = 49 y.o +/-10 y.o, min = 26 y.o, max = 77 y.o. ; 15 women and 33 men) afflicted with different pathologies participated in this study after they gave their informed consent (lateral epicondylitis (n=20), medial epicondylitis (n=3), tendinopathy of the gluteus medius (n=1), patellar tendinopathy (n=6), calcaneal tendinopathy (n=14), and plantar fasciitis (n=4)). To be recruited, the patients have had to suffer from a chronic tendinopathy for more than 3 months and be refractory to the following classical treatments : non steroidal anti inflammatory drugs, electrotherapy, deep transverse massage, eccentric revalidation and shockwaves therapy. A clinical examination was carried out to confirm the diagnosis and to exclude any other pathology, including metabolic disease. After this first step, a blood sample was drawn and analyzed to quantify the presence of various metabolic biomarkers (glycemia, thyroid hormons, cholesterolemia, uricemia) which are considered to be risk factors of tendinopathies. The initial pain assessment was made using a Visual Analogic Scale (VAS) of pain and a pressure algometer (Commander Algometer, Tech Medical) prior to the PRP collection. The PRP collection and injection protocol used has already been described in previous AbstractBackground : The aims of this study were to evaluate the effect of a single PRP injection followed by a standardized reeducation protocol among patients suffering from different tendinopathies, but otherwise healthy, and to determine the biomarkers that constitute good prognosis factors, if any.

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“…In the current decade, a therapy of autologous platelet-rich plasma (PRP) has been clinically applied for the treatment of the tendinopathy as tennis elbow, jumper's knee, Achilles tendinopathy, plantar fasciitis and other tendinopathies. Significant therapeutic effects of PRP were showed for lateral or medial epicondylitis in elbows, jumper's knee and Achilles tendinopathy compared to the conventional therapies as the injection of corticosteroid or a focused shockwave therapy [2][3][4][5][6][7][8][9][10][11][12] . On the other hand, there were some clinical examinations which showed no significant effects of PRP for the treatment of Achilles tendinopathy 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of autologous leukocyte-reduced platelet-rich plasma therapy for patellar tendinopathy in a rat treadmill model

Yoshida

Funasaki

Marumo

2016

MLTJ

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SummaryBackground: An autologous platelet-rich plasma (PRP) therapy has currently been applied for the tendinopathy; however, its efficacy and an optimal platelets concentration in PRP were uncertain. We analyzed them in an animal model prepared using a repetitive running exercise. Methods: We made the tendinopathy rat model of patellar tendon using a rodent treadmill machine. Rats with tendinopathy were injected with leukocyte-reduced PRP at the platelets concentration of 1.0×10 6 /µL (P10 group), PRP at the platelets concentration of 5.0×10 5 /µL (P5 group) or normal saline (control group) into the space between the patellar tendon and the fat pad bilaterally or were multiply dry-needled at the tibial insertion site (MN group) at once. To assess the pain-reliving effect, the spontaneous locomotor activities at night (12 h) were measured every day. Histological sections of the patellar tendon stained with hematoxylineosin or prepared by TdT-mediated dUTP nick end labeling were microscopically analyzed. Results: The numbers of spontaneous locomotor activities in the P10 group were significantly larger than those in the P5, MN or control groups and they recovered up to a healthy level. On histologic examinations, the numbers of microtears, laminations, or apoptotic cells in the patellar tendons in the P10 or P5 groups were significantly lower than those in the MN or control groups, although no significant differences were observed between the P10 and P5 groups. Conclusions:The injections of an autologous leukocyte-reduced PRP were effective for pain relief and for partial restoration of the patellar tendon in the tendinopathy rat model. The injections of a PRP at the platelets concentration of 1.0×10 6 /µL completely relieved the pain and were more effective than those at the platelets concentration of 5.0×10 5 /µL whereas there was no difference for the effect of histological restoration or apoptosis inhibition between them.

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One-year follow-up of platelet-rich plasma to treat chronic upper patellar tendinopathies

Cited by 22 publications

References 0 publications

Using platelet-rich plasma to treat jumper's knees: Exploring the effect of a second closely-timed infiltration

Using platelet-rich plasma to treat jumper's knees: Exploring the effect of a second closely-timed infiltration

Are There Biologic Factors of Good Prognosis after a Platelet Rich Plasma (PRP) Injection for Tendinopathies ?

Efficacy of autologous leukocyte-reduced platelet-rich plasma therapy for patellar tendinopathy in a rat treadmill model

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