One year follow-up of post-partum-onset depression: the role of depressive symptom severity and personality disorders

Uğuz, Faruk; Akman, Cemal; Sahingoz, Mine; Kaya, Nazmiye; Kucur, Rahim

doi:10.1080/01674820802545818

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Rates of depression and anxiety were elevated in women with PCOS (33.1% and 21.4%, vs. 17.0% and 10.6% in controls, respectively). Other studies have found similar associations between PCOS and depression and anxiety 62 – 65 , and report that 40% of women with PCOS experienced clinical depression 64 , and 34% of women with PCOS were diagnosed with anxiety 62 . Our observed prevalence was higher than that found in the Swedish population (16.4% vs. 11.1% in PCOS cases vs. controls) 31 .…”

Section: Discussionmentioning

confidence: 58%

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

et al. 2018

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Elevated levels of prenatal testosterone may increase the risk for autism spectrum conditions (autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated prenatal testosterone and its precursor sex steroids, a hypothesis from the prenatal sex steroid theory is that women with PCOS should have elevated autistic traits and a higher rate of autism among their children. Using electronic health records obtained from the Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2014, we conducted three matched case-control studies. Studies 1 and 2 examined the risk of PCOS in women with autism (n = 971) and the risk of autism in women with PCOS (n = 26,263), respectively, compared with matched controls. Study 3 examined the odds ratio (OR) of autism in first-born children of women with PCOS (n = 8588), matched to 41,127 controls. In Studies 1 and 2 we found increased prevalence of PCOS in women with autism (2.3% vs. 1.1%; unadjusted OR: 2.01, 95% CI: 1.22–3.30) and elevated rates of autism in women with PCOS (0.17% vs. 0.09%, unadjusted OR: 1.94 CI: 1.37–2.76). In Study 3 we found the odds of having a child with autism were significantly increased, even after adjustment for maternal psychiatric diagnoses, obstetric complications, and maternal metabolic conditions (unadjusted OR: 1.60, 95% CI: 1.28–2.00; adjusted OR: 1.35, 95% CI: 1.06–1.73). These studies provide further evidence that women with PCOS and their children have a greater risk of autism.

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Section: Discussionmentioning

confidence: 58%

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

et al. 2018

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“…Our findings agree with data from previous research concerning the personality organization as a factor of vulnerability in perinatal depression, which had found two different premorbid personalities at the basis of perinatal depression, using different assessment tools. Some research has identified a specific bond between obsessive-compulsive or dependent personality traits and depressive perinatal risk [ 10 , 12 – 14 ]. Vulnerability elements were linked to feelings of guilt and inadequacy, low self-esteem, and scarce autonomy, in association with rumination, lack of assertiveness, and hypersensitivity toward refusal.…”

Section: Resultsmentioning

confidence: 99%

“…The tendency of these mothers to experience a state of growing anxiety, along with a predisposition to face intimate relationships with an attitude of hyperresponsibility, can transform the engagement in child care into an emotional burden that can overwhelm these patients, leading to a depressive condition. Akman et al noticed that women with an avoidant, dependent, or obsessive-compulsive personality disease had greater chances of postpartum depressive onset [ 10 ]; Uguz et al highlighted that the most significant signs during the first year after giving birth were higher scores on the Edinburgh Postnatal Depression Scale (EPDS) and the existence of a personality disorder, particularly obsessive-compulsive and dependent disorders [ 12 ]. Further research linked the fear of relationships (typical of a C-cluster personality disorder) with postnatal depression symptoms [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

MMPI-2: Cluster Analysis of Personality Profiles in Perinatal Depression—Preliminary Evidence

Meuti

Marini

Grillo

et al. 2014

The Scientific World Journal

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Background. To assess personality characteristics of women who develop perinatal depression. Methods. The study started with a screening of a sample of 453 women in their third trimester of pregnancy, to which was administered a survey data form, the Edinburgh Postnatal Depression Scale (EPDS) and the Minnesota Multiphasic Personality Inventory 2 (MMPI-2). A clinical group of subjects with perinatal depression (PND, 55 subjects) was selected; clinical and validity scales of MMPI-2 were used as predictors in hierarchical cluster analysis carried out. Results. The analysis identified three clusters of personality profile: two “clinical” clusters (1 and 3) and an “apparently common” one (cluster 2). The first cluster (39.5%) collects structures of personality with prevalent obsessive or dependent functioning tending to develop a “psychasthenic” depression; the third cluster (13.95%) includes women with prevalent borderline functioning tending to develop “dysphoric” depression; the second cluster (46.5%) shows a normal profile with a “defensive” attitude, probably due to the presence of defense mechanisms or to the fear of stigma. Conclusion. Characteristics of personality have a key role in clinical manifestations of perinatal depression; it is important to detect them to identify mothers at risk and to plan targeted therapeutic interventions.

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“…In a sample of 34 women with depressive symptoms assessed with the EPDS at six weeks and one year post partum, those with postpartum depression persisting at one year (EPDS score >12) were significantly more likely to have an axis II disorder (odds ratio 21.1, 1.49 to 2.47; P=0.02) 100. Mothers with strong borderline and narcissistic traits or disorders often have difficulty with effective parenting, and studies suggest that their dysregulation of affect and difficulty with empathy and mentalizing may all have negative effects on child development 101.…”

Section: Personalized Treatment For Specific Clinical Characteristicsmentioning

confidence: 99%

Management of perinatal depression with non-drug interventions

Johansen

Robakis

Williams

et al. 2019

BMJ

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Perinatal depression is a common disorder that has been associated with serious risks to mother and child. Recently, screening for depression in pregnant and postpartum women has increased, as has the development of new psychotherapy and non-drug treatment modalities. Matching patients to treatments can be challenging, and although research into personalized treatment of major depression in the general population has increased, no published guidelines focus on personalized treatment approaches to perinatal depression. In particular, guidelines on non-drug treatments are lacking. This review summarizes the evidence on personalized non-drug treatment of perinatal depression, how to incorporate patients’ preferences, novel treatments under investigation, and the potential role of biomarkers in matching patients to treatment. The review provides recommendations for future research in personalized care of perinatal depression.

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One year follow-up of post-partum-onset depression: the role of depressive symptom severity and personality disorders

Abstract: This study suggests that women with PPD, scoring high in the EPDS scale 6 weeks post-partum and having a personality disorder, run a higher risk for depression at 1-year follow-up.

Cited by 11 publications

References 27 publications

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

MMPI-2: Cluster Analysis of Personality Profiles in Perinatal Depression—Preliminary Evidence

Management of perinatal depression with non-drug interventions

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