One-Year Multidisciplinary Follow-Up of Patients With COVID-19 Requiring Invasive Mechanical Ventilation

Zangrillo, Alberto; Belletti, Alessandro; Palumbo, Diego; Calvi, Maria Rosa; Guzzo, Francesca; Fominskiy, Evgeny; Ortalda, Alessandro; Nardelli, Pasquale; Ripa, Marco; Redaelli, Martina Baiardo; Borghi, Giovanni; Landoni, Giovanni; D’Amico, Filippo; Marmiere, Marilena; Righetti, Beatrice; Rocchi, Margherita; Saracino, Marco; Tresoldi, Moreno; Dagna, Lorenzo; Cobelli, Francesco De

doi:10.1053/j.jvca.2021.11.032

Cited by 44 publications

(49 citation statements)

References 71 publications

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“…Although several prospective studies have sought to examine long‐term CT changes in COVID‐19, these findings were limited by small cohort sizes 6,8–21 . In addition, the interpretations of each study varied due to the wide range of severity.…”

Section: Introductionmentioning

confidence: 99%

One‐year follow‐up CT findings in COVID‐19 patients: A systematic review and meta‐analysis

Watanabe

Iwagami

et al. 2022

Respirology

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Coronavirus disease 2019 (COVID-19) often causes radiological and functional pulmonary sequelae. However, evidence on 1-year follow-up of pulmonary sequelae is limited. We aimed to investigate the characteristics and time-course of pulmonary sequelae after recovery from COVID-19 through 1-year follow-up. We searched PubMed and EMBASE databases on 25 February 2022, and included studies with computed tomography (CT) findings at the 1-year follow-up. The extracted data on CT findings were analysed using a one-group meta-analysis. We further analysed the data in relation to COVID-19 severity, improvement rate and lung function. Fifteen eligible studies (N = 3134) were included. One year after COVID-19, 32.6% (95% CI 24.0-42.6, I 2 = 92.9%) presented with residual CT abnormalities. Ground-glass opacity and fibrotic-like changes were frequently observed in 21.2% (95% CI 15.4-28.4, I 2 = 86.7%) and 20.6% (95% CI 11.0-35.2, I 2 = 91.9%), respectively. While the gradual recovery was seen on CT (52.9% [midterm] vs. 32.6% [1 year]), the frequency of CT abnormalities was higher in the severe/ critical cases than in the mild/moderate cases (37.7% vs. 20.7%). In particular, fibrotic changes showed little improvement between 4-7 months and 1 year after COVID-19. Pulmonary function tests at 1 year also showed the decline in diffusing capacity of the lung for carbon monoxide, especially in severe/critical cases. Our meta-analysis indicated that residual CT abnormalities were common in hospitalized COVID-19 patients 1 year after recovery, especially fibrotic changes in severe/critical cases. As these sequelae may last long, vigilant observations and longer follow-up periods are warranted.

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Section: Introductionmentioning

confidence: 99%

One‐year follow‐up CT findings in COVID‐19 patients: A systematic review and meta‐analysis

Watanabe

Iwagami

et al. 2022

Respirology

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“…Although COVID-19 patients benefit from in-hospital rehabilitation [4], most patients do not qualify for this. Studies have shown promising results in recovery from COVID-19 [5,6], whereas others point out that some groups may still suffer from persisting respiratory impairments [7] and have low participation in society [8]. In-hospital care for COVID-19 has also been suggested to be a predictor of long sick leave [9].…”

Section: Introductionmentioning

confidence: 99%

Self-Assessed Aspects of Health 3 Months after COVID-19 Hospitalization—A Swedish Cross-Sectional Study

Larsson

Engwall

Palstam

et al. 2022

IJERPH

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It is not yet fully understood how the patients self-assess their overall health in the early recovery after COVID-19 and if certain patient groups are more prominent in perceived long-time effects of COVID-19. The aim of this study was to describe self-assessed aspects of health in body function, activity and participation 3 months after hospitalization due to COVID-19 and identify difference between groups depending in age, sex and level of hospital care. This cross-sectional study consists of self-assessed aspects of health and recovery in 168 participants (mean age 64 years old, 69% men) previously hospitalized patients due to COVID-19. We have previously published data, from hospital discharge, on this cohort were predominantly the older patients and previous ICU-treated participants were affected. In this study there were differences in between groups. Of the study population 72% perceived fatigue, 64% respiratory difficulties, 37% perceived symptoms of anxiety. Three-months after COVID-19 this cohort was overall still affected. The recovery process is multifaced and the cohort heterogeneous, hence the rehabilitation needs to be highly individualized, and the follow-up of this patient group is of importance regardless of age, sex and previous level of hospital care.

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“…Zangrillo et al 17 group applied a validated EuroQol Group EQ-5D-3L questionnaire in a follow-up of a small sample of patients (56) but found a smaller prevalence of post-COVID-19 symptoms in the 1-year follow-up, not distinguishing the symptoms time length.…”

Section: Discussionmentioning

confidence: 99%

“…Long-term, computed tomography images and other pulmonary sequelae were not evaluated in this study and will be the next steps. 16 , 17 , 20 , 21 …”

Section: Discussionmentioning

confidence: 99%

Post-discharge follow-up of patients with COVID-19: A Brazilian experience

et al. 2022

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Objective: The objective of this study is to evaluate post-acute symptoms in patients with confirmed severe and critical coronavirus disease 2019 infections. Methods: We evaluated patients with confirmed severe and critical coronavirus disease 2019 infections. Post-acute symptoms were defined as symptoms persisting 4 weeks after the onset of the symptoms and classified as pulmonary, muscular, hematologic, neuropsychiatric, renal, and dermatological. Results: We recovered data from 565 patients (43.7% female) with a mean age of 61.1 years. In 18.2%, at least one hospital readmission was necessary and 11.1% died. In 62.6%, there was at least one persistent symptom, and 28.8% had more than one. Among associated factors, obesity, intensive care support, and mechanical ventilation were related to persistent symptoms. Conclusion: The most prevalent symptoms were pulmonary and neuropsychiatric sequelae, as reported in previous studies. This finding underscores the severity of the coronavirus disease 2019 infection and the need for follow-up after recovery from the initial illness. Obese patients, those requiring mechanical ventilation, female patients, and increased hospital length are at greater chance of having persistent symptoms.

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One-Year Multidisciplinary Follow-Up of Patients With COVID-19 Requiring Invasive Mechanical Ventilation

Cited by 44 publications

References 71 publications

One‐year follow‐up CT findings in COVID‐19 patients: A systematic review and meta‐analysis

One‐year follow‐up CT findings in COVID‐19 patients: A systematic review and meta‐analysis

Self-Assessed Aspects of Health 3 Months after COVID-19 Hospitalization—A Swedish Cross-Sectional Study

Post-discharge follow-up of patients with COVID-19: A Brazilian experience

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