In Qatar, laparoscopic gastric sleeve (LGS) is a key surgical method for obesity treatment. This study assessed its impact on the lipid profiles of 863 obese patients, some with hyperlipidemia. Spanning five years (2015-2020), the research monitored metrics like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). Post-LGS, TC, and LDL levels decreased after three months, increased, and then significantly dropped from the 2<sup>nd</sup> to the 5<sup>th</sup> year. TG levels consistently declined over five years, while HDL saw a marked rise from six months to five years post-surgery. In conclusion, LGS positively influenced lipid profiles during certain post-operative periods.