One-Year Outcomes and Health Care Utilization in Survivors of Severe Acute Respiratory Syndrome

Tansey, Catherine M.

doi:10.1001/archinte.167.12.1312

Cited by 274 publications

(281 citation statements)

References 26 publications

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“…SARS cohorts have been studied at variable times of long-term follow-up; 2-year follow-up data has most recently become available [53]. What is different in the SARS cohort, in comparison to a group of ALI/ARDS patients or generally critically ill, is that the majority of patients did not require advanced support such as mechanical ventilation [54]. ICU length of stay was on average 10 days and 62% of patients received systemic corticosteroids [54].…”

Section: Musculoskeletal Causes Of Weakness Dyspnea and Fatiguementioning

confidence: 99%

Lung function and quality of life in survivors of the acute respiratory distress syndrome (ARDS)

Wilcox

Herridge

2011

La Presse Médicale

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Section: Musculoskeletal Causes Of Weakness Dyspnea and Fatiguementioning

confidence: 99%

Lung function and quality of life in survivors of the acute respiratory distress syndrome (ARDS)

Wilcox

Herridge

2011

La Presse Médicale

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“…3 The physical conditions of most of the patients continuously improved in the first year of follow-up, but their mental conditions showed limited signs of improvement. 4 The 1-year follow-up study after the outbreak found that some SARS survivors had persistent mental problems. 4,5 Many studies found that the status of being a health care worker at the time of SARS infection, [5][6][7][8][9][10] the severity of the infection, and the dosage of steroid usage were related to the short-term mental outcomes.…”

mentioning

confidence: 99%

Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors

Lam¹

2009

Arch Intern Med

702

560

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Background: Short-term follow-up studies of severe acute respiratory syndrome (SARS) survivors suggested that their physical conditions continuously improved in the first year but that their mental health did not. We investigated long-term psychiatric morbidities and chronic fatigue among SARS survivors.Methods: All SARS survivors from the hospitals of a local region in Hong Kong were assessed by a constellation of psychometric questionnaires and a semistructured clinical interview for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) to determine the presence of psychiatric disorders and chronic fatigue problems.Results: Of 369 SARS survivors, 233 (63.1%) participated in the study (mean period of time after SARS, 41.3 months). Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, and 27.1% met the modified 1994 Centers for Disease Control and Prevention criteria for chronic fatigue syndrome. Logistic regression analysis suggested that being a health care worker at the time of SARS infection (odds ratio [OR], 3.24; 95% confidence interval [CI], 1.12-9.39; P=.03), being unemployed at follow-up (OR, 4.71; 95% CI, 1.50-14.78; P=.008), having a perception of social stigmatization (OR, 3.03; 95% CI, 1.20-7.60; P=.02), and having applied to the SARS survivors' fund (OR, 2.92; 95% CI, 1.18-7.22; P=.02) were associated with an increased risk of psychiatric morbidities at follow-up, whereas application to the SARS survivors' fund (OR, 2.64; 95% CI, 1.07-6.51; P = .04) was associated with increased risk of chronic fatigue problems.Conclusions: Psychiatric morbidities and chronic fatigue persisted and continued to be clinically significant among the survivors at the 4-year follow-up. Optimization of the treatment of mental health morbidities by a multidisciplinary approach with a view for long-term rehabilitation, especially targeting psychiatric and fatigue problems and functional and occupational rehabilitation, would be needed.

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“…В нескольких наб людательных исследованиях уже проанализированы долгосрочные исходы пациентов после SARS [12][13][14].…”

Section: Discussionunclassified

“…C.M.Tansey et al представили результаты 12 ме сячного проспективного наблюдения за 117 больны ми, выжившими после эпизода SARS в Торонто [12]. Снижение пройденной дистанции в 6 MШT было выявлено у 31 % больных через 3 мес.…”

Section: Discussionunclassified

“…Относительно недавно появились исследования, посвященные долгосрочным последствиям ОПЛ / ОРДС, связанных с тяжелым острым респиратор ным синдромом [12][13][14], однако пока нет никаких данных о последствиях ОПЛ / ОРДС, вызванных пандемическим вирусом гриппа A / H1N1. Целью настоящего проспективного исследования явилось изучение долгосрочных последствий у больных, пе реживших ОПЛ / ОРДС, вызванный вирусом гриппа A / H1N1.…”

Section: оригинальные исследованияunclassified

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A one-year follow-up study of patients survived after ALI / ARDS caused by influenza A / H1N1

Авдеев¹,

Карчевская²,

Баймаканова³

et al. 2011

Pulʹmonologiâ (Mosk.)

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гг. мы стали свидетелями пандемии, вызванной вирусом гриппа А / H1N1 [1,2]. Панде мический вирус гриппа А / H1N1 отличался по сво ей патогенности от сезонного гриппа по 2 ключевым аспектам: во первых, вирусная инфекция гриппом А / H1N1 чаще всего поражала лиц более молодого возраста, а, во вторых, вирус был способен инфици ровать нижние дыхательные пути и вызвать быстро прогрессирующую пневмонию и острую дыхатель ную недостаточность (ОДН) [3]. В сезон пандемии гриппа A / H1N1 от 1 % до 10 % всех пациентов нуж дались в госпитализации, и общая летальность боль ных составила ~ 0,5 % [4]. При анализе данных боль ных гриппом A / H1N1, находившихся в отделениях интенсивной терапии (ОРИТ) разных городов РФ и разных стран, обращало на себя внимание рази тельное сходство этих пациентов: молодой возраст (в среднем 30-40 лет), очень высокая потребность в искусственной вентиляции легких (ИВЛ) (70-100 %) и очень высокая летальность (17-50 %) [5]. This was an open, prospective, 12 month study involved 22 patients survived from ALI / ARDS caused by influenza A / H1N1. The patients' lung function, arterial blood gases, physical tolerance in 6 min walking test (6MWT) and computed tomography (CT) of the lungs were monitored in 3, 6, and 12 months after discharge. During the follow up, all lung function parameters improved: FVC, TLC, and DLCO increased by 28.7 %, 17.5 % and 31.4 %, respectively (p < 0.05 for all). In a year after discharge, DLCO < 80 %pred. was found in 23 % of patients. At 12 months, the mean 6MWT distance increased from 454 ± 37 to 568 ± 47 m (р = 0.002). Significant improvement was noted in CT findings and 41% of patients had quite normal lung CT at 12 months. Therapy with NAC (n = 11) has led to more rapid improvement in DLCO (76.3 ± 11.8 %pred. vs 63.0 ± 10.6 %pred. in controls; р = 0.012) and 6MWT distance (533 ± 42 m vs 490 ± 46 m, respectively; р = 0.033) at 3 months. Therefore, patients survived from ALI / ARDS caused by influenza A / H1N1 demonstrated significant recovery of lung function, gas exchange, lung CT picture and physical tolerance but in some of them, persistent disorders of lung function (mainly in DLCO) and lung CT have been still found at 1 year after discharge. Treatment with NAC allowed more rapid improvement in DLCO and exercise tolerance. Key words: N acetylcysteine, influenza, acute respiratory distress syndrome. РезюмеЗадачей исследования было изучение долгосрочных последствий у больных, переживших острое повреждение легких / острый респираторный дистресс синдром (ОПЛ / ОРДС), вызванный вирусом гриппа A / H1N1, а также анализ влияния длительной терапии N ацетилцистеином -NAC (Флуимуцил, Zambon Group, Италия) на динамику клинических и функциональных изменений у данных пациентов. Исследование длительностью 12 мес. имело проспективный, открытый дизайн. В него были включены 22 больных, перенесших ОПЛ / ОРДС, вызванный вирусом гриппа A / H1N1. Через 3, 6 и 12 мес. после выписки пациентам проводились измерение функции внешнего дыхания (ФВД), газовый анализ артериальной крови, 6 минутный шаг...

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One-Year Outcomes and Health Care Utilization in Survivors of Severe Acute Respiratory Syndrome

Cited by 274 publications

References 26 publications

Lung function and quality of life in survivors of the acute respiratory distress syndrome (ARDS)

Lung function and quality of life in survivors of the acute respiratory distress syndrome (ARDS)

Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors

A one-year follow-up study of patients survived after ALI / ARDS caused by influenza A / H1N1

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