One-Year Outcomes of Intraarticular Fat Transplantation for Thumb Carpometacarpal Joint Osteoarthritis: Case Review of 99 Joints

Haas, E.; Eisele, Angelika; Arnoldi, Andreas; Paolini, Marco; Ehrl, Denis; Volkmer, Elias; Giunta, Riccardo E.

doi:10.1097/prs.0000000000006378

Cited by 33 publications

(37 citation statements)

References 31 publications

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“…Recent human studies have demonstrated satisfactory results with the intra-articular administration of purified and micro-fragmented adipose tissue for the treatment of knee, 18,19 subtalar, 20 carpometacarpal 21,22 and thumb osteoarthritis. [23][24][25] In veterinary literature, a recent study 26 suggested clinical evidence of pain control over a period of up to 180 days with intra-articular administration of autologous purified and micro-fragmented adipose tissue for the treatment of osteoarthritis in dogs. Several authors evaluated the effects of simultaneous intra-articular injection of culture-expanded autologous adipose-derived stem cells and platelet-rich plasma, [27][28][29][30][31] or plasma rich in growth factors 28,29 in dogs with stifle osteoarthritis 27 and hip osteoarthritis 28-32 using a plate force 29,30,32 or Tekscan pressuresensitive walkway analysis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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Objective The aim of this study was to investigate the safety, feasibility and clinical efficacy of a single intra-articular injection of autologous and purified micro-fragmented adipose tissue for the treatment of osteoarthritis (OA) in dogs. Study Design Twenty-one client-owned dogs with radiographically confirmed OA were recruited into this prospective study. Lameness and discomfort were evaluated by physical examination at day 0 and then 14, 30, 60 and 180 days after injection. Kinetic data and temporospatial parameters were obtained using a pressure-sensing walkway. Peak vertical force, vertical impulse and percentages of body weight distribution were determined. Owner perception data regarding their own dog's physical activity were also collected using the Canine Brief Pain Inventory. Results Radiographic scores for OA from days 0 to 180 were similar, except in two dogs. No major side effects were noted after injection. Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post-injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%). In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0. Conclusion Regenerative autologous adipose tissue injection therapy is a promising alternative to traditional analgesics treatment in patients with OA, associated with significant reductions in pain and lameness, delayed disease progression and improved quality of life.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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“…The following complications were described by Haas et al . 13 : one haematoma after liposuction occurred out of 89 patients (99 CMC joints). One patient suffered from severe pain and subsequently received firstly intravenous analgesics, later, after discharge, the pain was treated with oral medication and stopped 3 weeks postoperatively.…”

Section: Resultsmentioning

confidence: 98%

“…The wider cohort of patients available so far was published by Haas et al . 13 , who performed fat grafting in 99 first CMC joints. They found that pain under stress at 2 and 6 weeks as well as 3, 6 and 12 months was significantly lower than at baseline (p<0.001).…”

Section: Resultsmentioning

confidence: 99%

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Autologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis

Alessandri‐Bonetti¹,

Rovere²,

Fulchignoni³

et al. 2020

Orthop Rev (Pavia)

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Rhizarthrosis is a progressive and disabling pathology affecting the carpometacarpal joint. It’s very common in elderly patients and typically affects postmenopausal women. The diagnosis of rhizarthrosis is mainly made by using different physical examination tests and by evaluating the type of pain and it’s then confirmed by imaging. Over the last few years increasing attention has been devoted to the assessment of new treatment techniques for rhizarthrosis. In this context intra-articular injection of autologous fat grafting for cartilage regeneration has demonstrated promising results in experimental settings as an alternative to open surgery procedures. The aim of this study was therefore to sum up the evidences available so far on autologous fat grafting as an emerging treatment for patients affected by carpometacarpal rizarthrosis. An electronic literature research was carried out on Pubmed, Google Scholars and Cochrane Library using “fat grafting”, “fat graft”, “adipose”, “fat transfer” and “lipoaspirate” as search terms. Authors believe autologous fat grafting is an interesting technique, that hand surgeon should keep in mind especially in early stages of rhizarthrosis were pain has not been solved with non-surgical treatment.

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“…Data on a wider cohort of TBOA patients (n 99) treated with autologous fat injection was derived from the most recent study by Haas et al (Haas et al, 2020). They reported that pain during activities at 2 and 6 weeks as well as 3, 6, and 12 months was significantly lower than at baseline.…”

Section: New Emerging Intra-articular Therapiesmentioning

confidence: 99%

New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?

et al. 2021

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Thumb-base osteoarthritis (TBOA) is a common condition, mostly affecting post-menopausal women, often inducing a significant impact on quality of life and hand functionality. Despite its high prevalence and disability, the therapeutic options in TBOA are still limited and few have been investigated. Among the pharmacological strategies for TBOA management, it would be worthwhile to mention the injection-based therapy. Unfortunately, its efficacy is still the subject of debate. Indeed, the 2018 update of the European League Against Rheumatism (EULAR) recommendations for the management of hand osteoarthritis (OA) stated that intra-articular (IA) injections of glucocorticoids should not generally be used, but may be considered in patients with painful interphalangeal joints, without any specific mention to the TBOA localization and to other widely used injections agents, such as hyaluronic acid (HA) and platelet-rich plasma (PRP). Even American College of Rheumatology (ACR) experts conditionally recommended against IA HA injections in patients with TBOA, while they conditionally encouraged IA glucocorticoids. However, the recommendations from international scientific societies don’t often reflect the clinical practice of physicians who routinely take care of TBOA patients; indeed, corticosteroid injections are a mainstay of therapy in OA, especially for patients with pain refractory to oral treatments and HA is considered as a safe and effective treatment. The discrepancy with the literature data is due to the great heterogeneity of the clinical trials published in this field: indeed, the studies differ for methodology and protocol design, outcome measures, treatment (different formulations of HA, steroids, PRP, and schedules) and times of follow-up. For these reasons, the current review will provide deep insight into the injection-based therapy for TBOA, with particular attention to the different employed agents, the variety of the schedule treatments, the most common injection techniques, and the obtained results in terms of efficacy and safety. In depth, we will discuss the available literature on corticosteroids and HA injections for TBOA and the emerging role of PRP and other injection agents for this condition. We will consider in our analysis not only randomized controlled trials (RCTs) but also recent pilot or retrospective studies trying to step forward to identify satisfactory management strategies for TBOA.

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One-Year Outcomes of Intraarticular Fat Transplantation for Thumb Carpometacarpal Joint Osteoarthritis: Case Review of 99 Joints

Cited by 33 publications

References 31 publications

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Autologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis

New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?

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