One-Year Outcomes of Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold in an Ovine Model

Patel, Jay M.; Merriam, Aaron R.; Culp, Brian M.; Gatt, Charles J.; Dunn, Michael G.

doi:10.1177/0363546515624913

Cited by 51 publications

(60 citation statements)

References 41 publications

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“…A resorbable total meniscus replacement scaffold composed of a woven poly(desaminotyrosyl‐tyrosine dodecyl ester dodecanoate) [poly(DTD DD)] fiber reinforced collagen‐hyaluronan (COL‐HA) sponge was previously developed . The scaffold was designed to match the circumferential tensile and axial compressive mechanics of the native ovine meniscus with appropriate porosity (>70%) for tissue infiltration.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical characterization of a novel collagen‐hyaluronan infused 3D‐printed polymeric device for partial meniscus replacement

et al. 2019

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The menisci transmit load by increasing the contact area and decreasing peak contact stresses on the articular surfaces. Meniscal lesions are among the most common orthopedic injuries, and resulting meniscectomies are associated with adverse polycaprolactone contact mechanics changes and, ultimately, an increased likelihood of osteoarthritis. Meniscus scaffolds were fabricated by 3D‐printing a network of circumferential and radial filaments of resorbable polymer (poly(desaminotyrosyl‐tyrosine dodecyl ester dodecanoate)) and infused with collagen‐hyaluronan. The scaffold demonstrated an instantaneous compressive modulus (1.66 ± 0.44 MPa) comparable to native meniscus (1.52 ± 0.59 MPa). The scaffold aggregate modulus (1.33 ± 0.51 MPa) was within 2% of the native value (1.31 ± 0.36 MPa). In tension, the scaffold displayed a comparable stiffness to native tissue (127.6–97.1 N/mm) and an ultimate load of 33% of the native value. Suture pull‐out load of scaffolds (83.1 ± 10.0 N) was within 10% of native values (91.5 ± 15.4 N). Contact stress analysis demonstrated the scaffold reduced peak contact stress by 60–67% and increased contact area by 38%, relative to partial meniscectomy. This is the first meniscal scaffold to match both the axial compressive properties and the circumferential tensile stiffness of the native meniscus. The improvement of joint contact mechanics, relative to partial meniscectomy alone, motivates further investigation using a large animal model. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2457–2465, 2019.

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Section: Introductionmentioning

confidence: 99%

Biomechanical characterization of a novel collagen‐hyaluronan infused 3D‐printed polymeric device for partial meniscus replacement

et al. 2019

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“…As propriedades mecânicas do implante deverão ser próximas ao do menisco nativo. Para efeitos de comparação, deve-se testar o menisco nativo com a mesma metodologia de caracterização empregada ao material/protótipo de interesse no estudo (8) Por uma abordagem biológica o scaffold deve permitir adesão celular e promover uma rede de restauração, incluindo células meniscais e elementos matriciais (8,9,23). Além disto, deve ser biocompatível e apresentar produtos atóxicos resultantes do processo de degradação ou de interação com o organismo.…”

Section: Resultsunclassified

“…Os principais testes empregados para a caracterização da performance mecânica são: testes de tração e de compressão(1,3,4,17,18,23,29,30,33,50,51,53,54,58,59).Outro fator importante para o desenvolvimento de um scaffold é a porosidade em sua estrutura, pois influencia na promoção da aderência e proliferação celular. Ela está ligada com a tendência de formação tecidual no interior do arcabouço(9,16,17,32,38).…”

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Engenharia no Século XXI - Volume 4

Tinô¹,

Batista²,

Fontes³

et al. 2019

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“…54,[78][79][80][81][82] Meniscal repair and replacement with the use of scaffold-based technology has been described in Europe, with encouraging short-term results reported. [83][84][85][86][87][88][89][90][91][92] In general, scaffolds are categorized based on whether they incorporate cells and whether they are synthetic or biologic in origin. 93 Other important features of scaffolds include their mechanical properties and the type of tissue they target (ie, articular cartilage, meniscus, ligamentous tissue).…”

Section: Role Of Biologic Therapymentioning

confidence: 99%

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

Frank

Cotter

Strauss

et al. 2018

J Am Acad Orthop Surg

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The management of complex cartilage and meniscal pathology in young, athletic patients is extremely challenging. Joint preservation surgery is most difficult in patients with concomitant knee pathologies, including cartilage defects, meniscal deficiency, malalignment, and/or ligamentous insufficiency. Clinical decision making for these patients is further complicated by articular cartilage lesions, which often are incidental findings; therefore, treatment decisions must be based on the confirmed contribution of articular cartilage lesions to symptomatology. Surgical management of any of the aforementioned knee pathologies that is performed in isolation typically results in acceptable patient outcomes; however, concomitant procedures for the management of concomitant knee pathologies often are essential to the success of any single procedure. The use of biologic therapy as an alternative to or to augment more conventional surgical management has increased in popularity in the past decade, and indications for biologic therapy continue to evolve. Orthopaedic surgeons should understand knee joint preservation techniques, including biologic and reconstructive approaches in young, high-demand patients.

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One-Year Outcomes of Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold in an Ovine Model

Cited by 51 publications

References 41 publications

Biomechanical characterization of a novel collagen‐hyaluronan infused 3D‐printed polymeric device for partial meniscus replacement

Biomechanical characterization of a novel collagen‐hyaluronan infused 3D‐printed polymeric device for partial meniscus replacement

Engenharia no Século XXI - Volume 4

The Utility of Biologics, Osteotomy, and Cartilage Restoration in the Knee

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