Ongoing dissemination of OXA-244 carbapenemase-producing Escherichia coli in Switzerland and their detection

Masseron, Amandine; Poirel, Laurent; Falgenhauer, Linda; Imirzalioglu, Can; Kessler, Julie; Chakraborty, Trinad; Nordmann, Patrice

doi:10.1016/j.diagmicrobio.2020.115059

Cited by 14 publications

(19 citation statements)

References 31 publications

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“…Here, we used for the first time a systematic IMS approach for carbapenemase-producing Enterobacterales (CPE) in Germany by combining WGS data and epidemiological analyses on a national scale. Our results provide further evidence for the rapid and ongoing spread of bla OXA-244 [1,8]. In Germany, the spread was predominantly driven by genetically-clustered ST38 E. coli.…”

Section: Discussionsupporting

confidence: 59%

“…Multiple transmission hypotheses can be considered regarding the spread of OXA-244-producing E. coli isolates. The wide dissemination of these isolates in Europe [10,16,17] demonstrates the urgent need for additional investigations including additional data sources as well as enhanced screening capabilities [3].…”

Section: Kb Insertionmentioning

confidence: 99%

“…Although sensitivity as well as specificity of the PCR screening assay are high, bla OXA-244 has to be identified separately and is known be easily missed by phenotypic methods [17].…”

Section: Limitationsmentioning

confidence: 99%

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Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020

et al. 2020

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Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route.

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Section: Discussionsupporting

confidence: 59%

Section: Kb Insertionmentioning

confidence: 99%

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Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020

et al. 2020

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“…Recently, several federal states in Germany reported a rise in detection of community-acquired infections with ST38 OXA-244-producing E. coli [17]. Similar observations have been reported in other European countries [4,5,[19][20][21].…”

Section: Discussionsupporting

confidence: 73%

“…OXA-244 is a single-point mutation variant (Arg214Gly) of the globally circulating OXA-48 [3], resulting in lower minimum inhibitory concentration (MIC) values, which poses a major challenge for its detection [4,5].…”

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confidence: 99%

Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020

et al. 2020

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The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be under-reported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

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Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020

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Perreten

Poirel

et al. 2022

Eur J Clin Microbiol Infect Dis

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OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae. Bacteria-producing OXA-48-type enzymes are endemic in some parts of the world, including Europe and North Africa, and are a frequent cause of nosocomial infections. Despite the emergence of numerous OXA-48-type variants, the original variant, OXA-48, remains the most prevalent in E. coli. This study describes the epidemiology of OXA-48-producing E. coli isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) between January 2019 and December 2020.

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Ongoing dissemination of OXA-244 carbapenemase-producing Escherichia coli in Switzerland and their detection

Cited by 14 publications

References 31 publications

Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020

Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020

Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020

Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020

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