Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity

Sutherland, Tara E.; Shaw, Tovah N.; Lennon, Rachel; Herrick, Sarah E.; Rückerl, Dominik

doi:10.3389/fimmu.2021.715209

Cited by 12 publications

(10 citation statements)

References 88 publications

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“…15 Moreover, the macrophages have been reported to play a pivotal role in the progression of peritoneal deterioration. 14,32,33 Macrophages are likely to remain in peritoneal tissue after the onset of PD-related acute peritonitis. Notably, it has been reported that significance changes of the prevalence of macrophage/monocyte populations varies widely in PD patients, depending on the history of peritonitis.…”

Section: Discussionmentioning

confidence: 99%

“…NLRP3 inflammasome‐induced PD‐related acute peritonitis has been suggested to occur predominantly in the resident peritoneal monocytes and macrophages 15 . Moreover, the macrophages have been reported to play a pivotal role in the progression of peritoneal deterioration 14,32,33 . Macrophages are likely to remain in peritoneal tissue after the onset of PD‐related acute peritonitis.…”

Section: Discussionmentioning

confidence: 99%

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Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis

Kadoya,

Hirano,

Umeno

et al. 2023

The FASEB Journal

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During peritoneal dialysis (PD), the peritoneum is exposed to a bioincompatible dialysate, deteriorating the tissue and limiting the long‐term effectiveness of PD. Peritoneal fibrosis is triggered by chronic inflammation induced by a variety of stimuli, including peritonitis. Exposure to PD fluid alters peritoneal macrophages phenotype. Inflammasome activation triggers chronic inflammation. First, it was determined whether inflammasome activation causes peritoneal deterioration. In the in vivo experiments, the increased expression of the inflammasome components, caspase‐1 activity, and concomitant overproduction of IL‐1β and IL‐18 were observed in a mouse model of peritoneal fibrosis. ASC‐positive and F4/80‐positive cells colocalized in the subperitoneal mesothelial cell layer. These macrophages expressed high CD44 levels indicating that the CD44‐positive macrophages contribute to developing peritoneal deterioration. Furthermore, intravital imaging of the peritoneal microvasculature demonstrated that the circulating CD44‐positive leukocytes may contribute to peritoneal fibrosis. Bone marrow transplantation in ASC‐deficient mice suppressed inflammasome activation, thereby attenuating peritoneal fibrosis in a high glucose‐based PD solution‐injected mouse model. Our results suggest inflammasome activation in CD44‐positive macrophages may be involved in developing peritoneal fibrosis. The inflammasome‐derived pro‐inflammatory cytokines might therefore serve as new biomarkers for developing encapsulating peritoneal sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis

Kadoya,

Hirano,

Umeno

et al. 2023

The FASEB Journal

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“…One possible explanation for this effect is that long-term PD may affect the peritoneum, as Tara et al. [ 21 ] suggested. Alterations in tissue-resident macrophages could render long-term PD patients more susceptible to developing peritonitis.…”

Section: Discussionmentioning

confidence: 99%

Technique failure in peritoneal dialysis-related peritonitis: risk factors and patient survival

Yü

Zhu

et al. 2023

Renal Failure

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Objective This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The effect of peritonitis-associated technique failure on patient survival was also assessed. Methods Patients diagnosed with PDRP from January 1, 2010 to June 30, 2022 were retrospectively reviewed and analyzed. Relevant demographic, biochemical, and clinical data were collected. Univariate and multivariate logistic regression analyses were used to determine the predictors of peritonitis-associated technique failure in PD. Patients were divided into technique failure (F group) and nontechnique failure (NF group) groups. Patients were followed until death or until the date of Oct 1, 2022. Kaplan–Meier survival curves and landmark analysis were used to assess the survival of the PDRP cohort. Cox regression models were used to assess the association between potential risk factors and mortality. Results A total of 376 patients with 648 cases of PDRP were included in this study. Multivariate logistic regression analysis demonstrated that peritoneal dialysis (PD) duration (OR = 1.12 [1.03, 1.21], p = 0.005), dialysate WBC count on Day 3 after antibiotic therapy (OR = 1.41 [1.22, 1.64], p = 0.001), blood neutrophil-to-lymphocyte ratio (NLR) (OR = 1.83 [1.25, 2.70], p = 0.002), and serum lactate dehydrogenase (LDH) (OR = 4.13 [1.69, 10.11], p = 0.002) were independent predictors for technique failure in PDRP. Furthermore, serum high-density lipoprotein (HDL) (OR = 0.28 [0.13, 0.64], p = 0.002) was a protective factor against technique failure. According to the Kaplan–Meier analysis, patients experiencing peritonitis-associated technique failure had lower postperitonitis survival (log-rank = 4.326, p = 0.038). According to the landmark analysis, patients with a history of peritonitis-associated technical failures had a higher 8-year mortality after peritoneal dialysis. A Cox model adjusted for plausible predetermined confounders showed that technique failure was independently associated with all-cause mortality. Conclusions Dialysate WBC count on Day 3, PD duration, NLR, and LDH were independent risk factors for technique failure, whereas HDL was a protective factor. Peritonitis-associated technique failure had a higher risk of mortality and adverse effects on postperitonitis survival.

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“…A recent study showed that chronic exposure to PDFs alters resident MØs homeostatic phenotype, including the lost expression of anti-inflammatory and efferocytosis markers and enhanced inflammatory response [ 57 ]. Another study demonstrated the role of M1 instead of M2 MØs in peritoneal damage by depleting and transplanting different MØs populations into PDF-exposed mice [ 58 ].…”

Section: Cellular and Molecular Mechanisms Implicated In The Damage O...mentioning

confidence: 99%

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Trionfetti

Marchant

González-Mateo

et al. 2023

IJMS

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Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient KRT presenting benefices as home therapy. In PD patients, the peritoneum is chronically exposed to PD fluids containing supraphysiologic concentrations of glucose or other osmotic agents, leading to the activation of cellular and molecular processes of damage, including inflammation and fibrosis. Importantly, peritonitis episodes enhance peritoneum inflammation status and accelerate peritoneal injury. Here, we review the role of immune cells in the damage of the peritoneal membrane (PM) by repeated exposure to PD fluids during KRT as well as by bacterial or viral infections. We also discuss the anti-inflammatory properties of current clinical treatments of CKD patients in KRT and their potential effect on preserving PM integrity. Finally, given the current importance of coronavirus disease 2019 (COVID-19) disease, we also analyze here the implications of this disease in CKD and KRT.

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Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity

Cited by 12 publications

References 88 publications

Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis

Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis

Technique failure in peritoneal dialysis-related peritonitis: risk factors and patient survival

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

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