Ongoing symptoms after eradication of Helicobacter pylori: Psychiatric disorders may accompany!

Ünal, Hakan; Akın, Ebru; Aydın, I.; Korkmaz, Murat; Özel, Sevgi; Şelçuk, Haldun; Yılmaz, Uğur

doi:10.4318/tjg.2013.0582

Cited by 9 publications

(8 citation statements)

References 20 publications

(27 reference statements)

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“…The prevalence of probable case of depression found among patients with H . pylori infection (11.9%) in this study was lower than the findings of studies conducted in Turkey (24.1%) [ 38 ] and the Kingdom of Bahrain (32.1%) [ 20 ]. The difference may again be related to the tools used to assess depression (PHQ-9 vs Composite International Diagnostic Interview (CIDI) and Hamilton Depression Rating Scale (HDRS)).…”

Section: Discussioncontrasting

confidence: 86%

Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia

Soboka

Gudina²,

Gashaw³

et al. 2022

PLoS ONE

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Background Depression is the most common mental health problem, and frequently associated with physical illnesses. A link between depression, dyspepsia and Helicobacter pylori (H. pylori) infection has previously been reported. However, there is limited data regarding the association between these conditions from sub-Saharan Africa where they are highly prevalent. Objective This study aimed at elucidating the potential associations between depression, dyspepsia and H. pylori infection in Ethiopia. Methods We conducted a community based cross-sectional study involving urban and rural residents aged 13 years or older in Jimma Zone, southwest Ethiopia. A total of 871 participants were evaluated using a structured case reporting format for symptoms of dyspepsia and the patient health questionnaire (PHQ-9) for depression. Additionally, participants were assessed for H. pylori infection using stool antigen and serology tests. A multivariate logistic regression was used to identify the association between depression, dyspepsia and H. pylori infection after controlling for potential confounders. Results The prevalence of PHQ-9 scores indicative of probable case of depression among all participants was 10.9%. The prevalence of probable case of depression among patients who had at least one symptom of dyspepsia was 13.3% (X2 = 15.1 = p-value<0.001), while it was 11.9% (X2 = 1.23, p-value = 0.26) among patients who had H. pylori infection. Out of patients who took medications for their heartburn in the past 30 days, 14.9% (X2 = 3.6, p-value = 0.06) had probable case of depression. Dyspepsia symptoms such as epigastric discomfort (aOR = 2.59, 95%CI = 1.14, 5.87), postprandial fullness (aOR = 1.70, 95%CI = 1.48, 5.51), nausea (aOR = 1.71, 95%CI = 1.04, 2.82) excessive belching (aOR = 0.53, 95%CI = 0.31, 0.92) were associated with probable case of depression. However, being H. pylori test positive, gender, and age were not associated with probable case of depression. Conclusions There was an increased prevalence of probable case of depression among patients who had dyspepsia symptoms and H. pylori infection. Longitudinal studies are needed to examine possible further determinants of association between symptoms of dyspepsia and probable case of depression.

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Section: Discussioncontrasting

confidence: 86%

Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia

Soboka

Gudina²,

Gashaw³

et al. 2022

PLoS ONE

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“…They concluded that H. pylori eradication might be the key to success for the treatment of F.D patients and to prevent the development of gastric cancer [34]. Ünal et al enrolled 54 patients with functional dyspepsia and H. pylori infection without knowing their psychiatric illnesses [35]. They found 22 of them to have at least one psychiatric illness; the most common was depression in about 13 patients.…”

Section: Reviewmentioning

confidence: 99%

“…They found 22 of them to have at least one psychiatric illness; the most common was depression in about 13 patients. They concluded that psychiatric illness should be considered for patients who fail the treatment of symptoms after H. pylori eradication, as it will affect their treatment [35]. A prospective study by Kabeer et al to determine the prevalence of H. pylori and depression in patients with functional dyspepsia and to assess the outcome in three months after appropriate intervention enrolled 120 patients with functional dyspepsia, who underwent upper endoscopy to confirm H. pylori infection with either of two tests- the urease test or histopathology [36].…”

Section: Reviewmentioning

confidence: 99%

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

Quraan

Beriwal

Sangay

et al. 2019

Cureus

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The clinical practice of adding antidepressant drugs to the therapy for the eradication of Helicobacter pylori (H. pylori) in addition to the standard drug regimen is not yet well established. This study aims to establish if there is an association between H. pylori gastritis and depression and to further analyze the therapeutic effect of antidepressants on symptomatic relief in gastritis. A systematic review was done using articles collected within the last seven years without regional or language localization obtained using PubMed, PubMed Central® (PMC), Google Scholar, and the Cochrane controlled trials. The search terms included Helicobacter pylori, depression, functional dyspepsia, and antidepressants. We selected three randomized controlled trials (RCTs), eight cross-sectional studies, four prospective studies, one cohort study, and two review articles. Trials that were prescribed antidepressants for clinical improvement of dyspepsia in patients with H. pylori gastritis that showed no improvement after eradication therapy standard regimen were included. In conclusion, patients who showed no improvement in functional dyspepsia after H. pylori eradication were seen to improve on antidepressant therapy. Further investigation and studies to analyze this correlation are recommended.

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“…It is also possible that psychiatric disorders in H. pylori-infected subjects result from disease overlap, with comorbidity in 40% of patients with functional dyspepsia, of which depression is the most prevalent (24%) [111] .…”

Section: Disordersmentioning

confidence: 99%

“…Furthermore, additional placebo-controlled trials and a meta-analysis did not show improvement in dyspeptic symptoms with H. pylori eradication [129][130][131] . Discrepancies regarding symptomatic response to H. pylori eradication may relate to commonly occurring comorbid psychiatric disorders, which can affect treatment outcome [111] . H. pylori infection is also considered a cause of visceral hypersensitivity in patients with IBS, as individuals reporting typical abdominal discomfort after rectal barostat testing were more frequently H. pylori positive [42,43] .…”

Section: H Pylori and Visceral Sensitivitymentioning

confidence: 99%

Brain-gut axis in the pathogenesis ofHelicobacter pyloriinfection

Budzyński¹

2014

WJG

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Helicobacter pylori (H. pylori) infection is the main pathogenic factor for upper digestive tract organic diseases. In addition to direct cytotoxic and proinflammatory effects, H. pylori infection may also induce abnormalities indirectly by affecting the brain-gut axis, similar to other microorganisms present in the alimentary tract. The brain-gut axis integrates the central, peripheral, enteric and autonomic nervous systems, as well as the endocrine and immunological systems, with gastrointestinal functions and environmental stimuli, including gastric and intestinal microbiota. The bidirectional relationship between H. pylori infection and the brain-gut axis influences both the contagion process and the host's neuroendocrine-immunological reaction to it, resulting in alterations in cognitive functions, food intake and appetite, immunological response, and modification of symptom sensitivity thresholds. Furthermore, disturbances in the upper and lower digestive tract permeability, motility and secretion can occur, mainly as a form of irritable bowel syndrome. Many of these abnormalities disappear following H. pylori eradication. H. pylori may have direct neurotoxic effects that lead to alteration of the brain-gut axis through the activation of neurogenic inflammatory processes, or by microelement deficiency secondary to functional and morphological changes in the digestive tract. In digestive tissue, H. pylori can alter signaling in the brain-gut axis by mast cells, the main brain-gut axis effector, as H. pylori infection is associated with decreased mast cell infiltration in the digestive tract. Nevertheless, unequivocal data concerning the direct and immediate effect of H. pylori infection on the brain-gut axis are still lacking. Therefore, further studies evaluating the clinical importance of these host-bacteria interactions will improve our understanding of H. pylori infection pathophysiology and suggest new therapeutic approaches.

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Ongoing symptoms after eradication of Helicobacter pylori: Psychiatric disorders may accompany!

Abstract: Background/aims: The precise mechanism of functional dyspepsia is yet to be elucidated. Helicobacter pylori infection and psychi

Cited by 9 publications

References 20 publications

Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia

Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

Brain-gut axis in the pathogenesis ofHelicobacter pyloriinfection

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