Onion and garlic oils inhibit tumor promotion

Belman, Sidney

doi:10.1093/carcin/4.8.1063

Cited by 208 publications

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“…The high degree of antimutgenicity of garlic extract is probably due to the wealth of organosulphur compounds it contains. Phytochemical constituents of garlic include ajoene, Allian allin, allycystein, diallylsulphide and over 100 other biologically useful secondary metabolites have been reported to be inherent in the valuable spice (Dorant, et al, 1993 andBelman, 1983).…”

Section: Resultsmentioning

confidence: 99%

Antimutagenic and potential anticarcinogenic activities of aloe-vera gel and aqueous garlic extract in the bacterial reverse mutation test (ames assay)

Ogunjobi¹,

Fagade²,

David³

2010

African Journal of Biomedical Research

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The study was carried out to verify the potential anticarcinogenic and antimutagenic activity of garlic and aloe-vera. The ability of aqueous garlic extract and Aloe-Vera gel to inhibit mutation in tester strain of Escherichia coli WP2 uvrA was determined in this study. (The tester E. coli tryptophan auxotroph strain was obtained from Yale University U.S.A.).The spontaneous mutation rate of E. coli WP 2 uvrA was determined in the Ames assay to be 2.2 x 10 -7 . The acridine mutagen showed 333.8% increase of spontaneously reverting colonies of the tester strain. Different concentrations of aqueous garlic extract and aloe-vera gel conferred varying degrees of antimutagenic activities on the tester E. coli WP2 uvrA. Aqueous garlic extract was found to have its highest antimutagenic activity at a concentration of 0.5g/cm 3 (the highest concentration tested) with 81.02% reduction in revertant colonies were observed. 0.1g/cm -3 and 0.25g/cm -3 garlic extract produced 72.16% and 74.82% reduction of revertant colonies respectively. Aloe-Vera gel produced 43.6%, 37.2% and 33.68% reduction in revertant colonies at concentration of 0.5ml, 0.2ml and 0.1ml per plate of the E. coli respectively. From the result obtained in this study, garlic has tremendous potential antimutagenic and anticarcinogenic substances..

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Section: Resultsmentioning

confidence: 99%

Antimutagenic and potential anticarcinogenic activities of aloe-vera gel and aqueous garlic extract in the bacterial reverse mutation test (ames assay)

Ogunjobi¹,

Fagade²,

David³

2010

African Journal of Biomedical Research

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“…The homogenized supernatant was centrifuged at 100 000g for 30 min. The amount of radioactive CO 2 produced from [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]ornithine was assayed to estimate the ODC activity. Statistical analysis Statistical analysis of data was performed by employing Student's t test.…”

Section: Immunohistochemical Staining Of Gst-p and Pcnamentioning

confidence: 99%

“…People who consume garlic regularly have a lower gastric cancer death rate. 1,2) Further, it has numerous chemical constituents which inhibit the progression of different types of cancer in experimental chemical carcinogeneses. [1][2][3][4][5][6][7][8][9][10][11] Many reports have emphasized the preventive potential of oilsoluble orangosulfur compounds (OSCs) present in the allium family, on chemical carcinogenesis.…”

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confidence: 99%

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Inhibitory Effects of S‐Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis

Vijayaraghavan

Wanibuchi

Takada

et al. 2000

Japanese Journal of Cancer Research

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The effects of S-methylcysteine (SMC) and cysteine on the promotion stages of rodent hepatocarcinogenesis in a medium-term bioassay previously developed by Ito were examined. Initiation was induced by a single dose of diethylnitrosamine (DEN), followed by dietary administration of the promoter sodium phenobarbital (NaPB) 2 weeks later, for 6 weeks. Partial hepatectomy was conducted on all the animals at week 3. Inhibitory potential was evaluated by analyzing two markers of carcinogenesis, namely numbers of glutathione S-transferase placental form (GST-P)-positive foci, and proliferating cell nuclear antigen (PCNA). In addition, the level of ornithine decarboxylase (ODC), one of the rate-limiting enzymes of polyamine metabolism induced by promoters, was analyzed. SMC and cysteine induced significant reduction in the areas of GST-P-positive foci. A significant reduction in the PCNA index was observed in the entire liver as well as in GST-Ppositive areas. SMC also induced down-regulation of the ODC enzyme activity. Thus, SMC and cysteine were found to inhibit the promotion stage of DEN-induced hepatocarcinogenesis. No cocarcinogenic effects were evident on administration of either of these chemicals with NaPB.

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“…Organosulfur compounds present in garlic and onions, such as allyl sulfide (DAS), allyl disulfide (DADS), and allyl methyl di-and trisulfide, and garlic and onion oil have been found to inhibit carcinogenesis in several organs (Belman, 1983;Wargovich et al, 1987;Sparnins et al, 1988;Wattenberg et al, 1989;Takahashi et al, 1992). Inhibition of the P450 enzymes responsible for the metabolic activation of the carcinogenic and toxic chemicals is believed to be a major mechanism of the observed chemopreventive effect of DAS (Takada et al, 1994;Burchell et al, 1995;Hong, 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of organosulfur compounds on the expression of UDP-glucuronosyltransferase and thyroid hormone level in TCDD-treated rats

Hong

Kim²

1997

Exp Mol Med

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In this study, we investigated the effect of organosulfur compounds including, diallyl sulfide (DAS), garlic extract, and dially disulfide (DADS) on inducible expression of UDP-glucuronosyltransferase (UGT1) and thyroid hormone level in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. We measured UGT1 gene expression in rat liver and lung tissues after treatments. We found that a correlation was found to exist between UGT1 gene expression and active T 4 concentrations. The total concentration of plasma T 4 decreased in TCDD-alone treated male and female rats compared to control animals (TCDDalone < control). Plasma T 4 concentration in TCDD + DAS, TCDD + garlic extract and TCDD + DADS treated groups were moderately higher than in TCDD alone animals, but lower than control animals. TCDD + DAS, TCDD + garlic extract and TCDD + DADS moderately increased T 4 glucuronidation and moderately reduced total T 4 . The nonthyroidal nature of thyroid hormone reduction observed in this study extends the evidence for microsomal enzyme inducers as indirect thyroid tumor promoters in rats. Furthermore, the results of present study suggest protective effects of DAS, garlic extract, or DADS on TCDDinduced changes.

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Onion and garlic oils inhibit tumor promotion

Abstract: The tumor yield and incidence of phorbol-myristate-acetate promotion were inhibited in a dose-dependent manner over the range of 10-10 000 micrograms onion oil, applied three times per week. Garlic oil was also inhibitory but was less effective.

Cited by 208 publications

References 0 publications

Antimutagenic and potential anticarcinogenic activities of aloe-vera gel and aqueous garlic extract in the bacterial reverse mutation test (ames assay)

Antimutagenic and potential anticarcinogenic activities of aloe-vera gel and aqueous garlic extract in the bacterial reverse mutation test (ames assay)

Inhibitory Effects of S‐Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis

Effect of organosulfur compounds on the expression of UDP-glucuronosyltransferase and thyroid hormone level in TCDD-treated rats

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