Online beam monitoring in the treatment of ocular pathologies at the INFN Laboratori Nazionali del Sud-Catania

Givehchi, N.; Marchetto, F.; Valastro, L.; Ansarinejad, Abdolkazem; Attili, A.; Garella, Ma; Giordanengo, S.; Monaco, V.; Pardo-Montero, Juan; Sacchi, R.; Attanasio, Roberto; Bourhaleb, F.; Cirio, R.; Rosa, A. La; Pecka, A.; Peroni, C.; Cirrone, G.A.P.; Cuttone, G.; Donetti, M.; Iliescu, S.; Pittera, S.; Raffaele, L.

doi:10.1016/j.ejmp.2010.10.004

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Fig. 1 shows a picture of the treatment room and a sketch of the proton beam line, with indication of the main transport elements [23,24]. The proton beam exits in air through a 50 mm kapton window.…”

Section: Proton Beam Linementioning

confidence: 99%

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Marinelli¹,

Pompili²,

Prestopino³

et al. 2014

Nuclear Instruments and Methods in Physics Research Section A:

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a b s t r a c tA synthetic single crystal diamond based Schottky photodiode was tested at INFN-LNS on the proton beam line (62 MeV) dedicated to the radiation treatment of ocular disease. The diamond detector response was studied in terms of pre-irradiation dose, linearity with dose and dose rate, and angular dependence. Depth dose curves were measured for the 62 MeV pristine proton beam and for three unmodulated range-shifted proton beams; furthermore, the spread-out Bragg peak was measured for a modulated therapeutic proton beam. Beam parameters, recommended by the ICRU report 78, were evaluated to analyze depth-dose curves from diamond detector. Measured dose distributions were compared with the corresponding dose distributions acquired with reference plane-parallel ionization chambers. Field size dependence of the output factor (dose per monitor unit) in a therapeutic modulated proton beam was measured with the diamond detector over the range of ocular proton therapy collimator diameters (5-30 mm). Output factors measured with the diamond detector were compared to the ones by a Markus ionization chamber, a Scanditronix Hi-p Si stereotactic diode and a radiochromic EBT2 film. Signal stability within 0.5% was demonstrated for the diamond detector with no need of any pre-irradiation dose. Dose and dose rate dependence of the diamond response was measured: deviations from linearity resulted to be within 70.5% over the investigated ranges of 0.5-40.0 Gy and 0.3-30.0 Gy/min respectively. Output factors from diamond detector measured with the smallest collimator (5 mm in diameter) showed a maximum deviation of about 3% with respect to the high resolution radiochromic EBT2 film. Depth-dose curves measured by diamond for unmodulated and modulated beams were in good agreement with those from the reference plane-parallel Markus chamber, with relative differences lower than 7 1% in peak-to-plateau ratios, well within experimental uncertainties. A 2.5% variation in diamond detector response was observed in angular dependence measurements carried-out by varying the proton beam incidence angle in the polar direction. The dosimetric characterization of the tested synthetic single crystal diamond detector clearly indicates its suitability for relative dosimetry in ocular therapy proton beams, with no need of any correction factors accounting for dose rate and linear energy transfer dependence.

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Section: Proton Beam Linementioning

confidence: 99%

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Marinelli¹,

Pompili²,

Prestopino³

et al. 2014

Nuclear Instruments and Methods in Physics Research Section A:

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“…The experimental measurements were performed at the CATANA proton therapy facility (beam of 62 MeV/ A of energy) for the therapeutic treatment of choroidal or iris melanoma, eye melanoma tumors (INFN-LNS, Catania, Italy). Starting from 2016, CATANA facility allows animal irradiation, in collaboration with University of Catania, taking the advantage of a dedicated holding system in-house designed to perform high precision and reproducible small animal irradiation (Givehchi et al, 2011;Russo et al, 2017). The beam goes out in the air and flies for 3 m traversing through elements modifying its energy and the shape before hitting the target (scattering foils spreading the beam laterally; collimators defining beam profile and target shape; range shifter and modulator wheel modifying the particle range and the SOBP dimension).…”

Section: Catana Experimental Room and Dose Delivery Systemmentioning

confidence: 99%

Transcriptional modulations induced by proton irradiation in mice skin in function of adsorbed dose and distance

Licursi

Wang

Nisio

et al. 2021

Journal of Radiation Research and Applied Sciences

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Hadron therapy by proton beams represents an advanced anti-cancer strategy due to its highly localized dose deposition allowing a greater sparing of normal tissue and/or organs at risk compared to photon/electron radiotherapy. However, it is not clear to what extent nontargeted effects such as transcriptional modulations produced along the beamline may diffuse and impact the surrounding tissue. In this work, we analyze the transcriptome of protonirradiated mouse skin and choose two biomarker genes to trace their modulation at different distances from the beam's target and at different doses and times from irradiation to understand to what extent and how far it may propagate, using RNA-Seq and quantitative RT-PCR. In parallel, assessment of lipids alteration is performed by FTIR spectroscopy as a measure of tissue damage. Despite the observed high individual variability of expression, we can show evidence of transcriptional modulation of two biomarker genes at considerable distance from the beam's target where a simulation system predicts a significantly lower adsorbed dose. The results are compatible with a model involving diffusion of transcripts or regulatory molecules from high dose irradiated cells to distant tissue's portions adsorbing a much lower fraction of radiation.

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“…Through its path, the beam is intercepted by various elements and is modified in energy and shape in order to be used in clinical applications. Among these elements there are the scattering foils (to spread the beam laterally), collimators (to define beam profile in accordance to the tumour shape), monitor chambers (to measure the dose delivered) [20,21]. The presence of two x-ray tubes, positioned along and orthogonal to the beam direction, allows to verify the exact positioning of the target using radiopaque markers.…”

Section: Experimental Catana Beam Linementioning

confidence: 99%

Preliminary study for small animal preclinical hadrontherapy facility

Russo

Pisciotta

Cirrone

et al. 2017

Nuclear Instruments and Methods in Physics Research Section A:

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Online beam monitoring in the treatment of ocular pathologies at the INFN Laboratori Nazionali del Sud-Catania

Cited by 7 publications

References 9 publications

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Dosimetric characterization of a synthetic single crystal diamond detector in a clinical 62 MeV ocular therapy proton beam

Transcriptional modulations induced by proton irradiation in mice skin in function of adsorbed dose and distance

Preliminary study for small animal preclinical hadrontherapy facility

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