2024
DOI: 10.1021/acs.analchem.4c02549
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Online, Bottom-up Characterization of Histone H4 4–17 Isomers

Cassandra N. Fuller,
Kevin Jeanne Dit Fouque,
Lilian Valadares Tose
et al.

Abstract: The "Histone Code" is comprised of specific types and positions of post-translational modifications (PTMs) which produce biological signals for gene regulation and have potential as biomarkers for medical diagnostics. Previous work has shown that electron-based fragmentation improves the sequence coverage and confidence of labile PTM position assignment. Here, we evaluated two derivatization methods (e.g., irreversible -propionylation and reversible−citraconylation) for bottom-up analysis of histone H4 4−17 pr… Show more

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