The cold-end system of a nuclear power plant is a key complex node connecting the power generation system with the variable environmental conditions, and its operation, economy, and stability have become the main obstacles to further improving the performance of the first and second circuits. The current research on the interactions between the cold-end system and the thermal cycle of nuclear power mainly adopts the micropower model, while the existing condenser model does not take into account the influence of the turbine exhaust resistance and exhaust flow and other factors on the condenser vacuum change caused by the change in the circulating water flow rate and temperature in determining the optimal vacuum. This ignores the interactions between the equipment and the interconnections between the parameters, which results in the reduction of the model’s accuracy. This paper takes a nuclear power unit as an example, adopts the “constant flow calculation” method to calculate the heat balance of the two-loop thermal system of the nuclear power plant, and constructs an integrated simulation model of the reaction environment variables, the cold-end system, and the thermal cycle. Taking the circulating water temperature and flow rate as variables, the errors of the separate condenser model and the coupled model in circulating water parameter changes were obtained under the condition of satisfying the thermal system operation, and the circulating water temperature and flow rate change ranges applied by the separate condenser model were analyzed in order to reduce the amount of calculations when the unit power error was 1%. The results show that the circulating water temperature is 4 °C, the applicable range of the circulating water flow rate is 42 m3/s to the rated flow rate, the applicable range of the circulating water temperature is 20 °C, the applicable range of the circulating water flow rate is 32.12 m3/s to the rated flow rate, the applicable range of the circulating water temperature is 26 °C, the applicable range of the circulating water flow rate is 38.63 m3/s to the rated flow rate, the applicable range of the circulating water temperature is 30 °C, and the applicable range of the circulating water flow rate is 45 m3/s to the rated flow rate. At a circulating water temperature of 26 °C, the applicable range of the circulating water flow is between 38.63 m3/s and the rated flow; at a circulating water temperature of 30 °C, the applicable range of the circulating water flow is between 45.64 m3/s and the rated flow.