This literature review aims to understand the recent developments in the field of upscaling and upskilling in the digital transformation of business, from an Industry 5.0 prospective. It used a comprehensive search of relevant peer-reviewed journal articles, industry reports, and online sources to gather the relevant data. The findings indicate that upscaling is essential for industry 5.0, and that businesses should invest in upskilling and upscaling programs to meet the changing demands of the digital economy. This literature review provides a comprehensive analysis of the current state of upscaling and upskilling in the digital transformation of business and provides insights into the future direction of this field. It also highlights the importance of collaboration between businesses, governments, and educational institutions to ensure that the workforce is prepared for the future of work.