Online Literature Searching for Research Projects in Pharmaceutical Sciences

Saharan, Vikas Anand; Banerjee, Surojit; Dobhal, Swati; Sarangi, Manoj Kumar; Singh, Anupama

doi:10.1007/978-981-16-5180-9_14

Cited by 1 publication

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Candesartan's absorption, distribution, metabolism, and excretion mechanism were determined by accumulating data on its physicochemical properties, conducting in vitro experiments, and extending the experiments to humans TherapeuTic advances in drug safety with ex vivo correlated factors and scalars. 25 The final model was developed using the 18 compartments, each of which could be further divided into sub-compartments built into the PK-Sim software. 26 The input compound parameters of candesartan and candesartan cilexetil, including physicochemical properties, specific intestinal permeability, enzymatic kinetic, and glomerular filtration fraction (f GFR ) parameters, were obtained from DrugBank, the guidelines of the US Food and Drug Administration or the European Medicines Agency, and the literature.…”

Section: Adult Pbpk Model Developmentmentioning

confidence: 99%

Physiologically based pharmacokinetic modeling of candesartan to predict the exposure in hepatic and renal impairment and elderly populations

Guo,

Zhu,

Zhang

et al. 2023

Therapeutic Advances in Drug Safety

View full text Add to dashboard Cite

Background: Candesartan cilexetil is a widely used angiotensin II receptor blocker with minimal adverse effects and high tolerability for the treatment of hypertension. Candesartan is administered orally as the prodrug candesartan cilexetil, which is wholly and swiftly converted to the active metabolite candesartan by carboxylesterase during absorption in the intestinal tract. In populations with renal or hepatic impairment, candesartan’s pharmacokinetic (PK) behavior may be altered, necessitating dosage adjustments. Objectives: This study was conducted to examine how the physiologically based PK (PBPK) model characterizes the PKs of candesartan in adult and geriatric populations and to predict the PKs of candesartan in elderly populations with renal and hepatic impairment. Design: After developing PBPK models using the reported physicochemical properties of candesartan and clinical data, these models were validated using data from clinical investigations involving various dose ranges. Methods: Comparing predicted and observed blood concentration data and PK parameters was used to assess the fit performance of the models. Results: Doses should be reduced to approximately 94% of Chinese healthy adults for the Chinese healthy elderly population; approximately 92%, 68%, and 64% of that of the Chinese healthy adult dose in elderly populations with mild, moderate, and severe renal impairment, respectively; and approximately 72%, 71%, and 52% of that of the Chinese healthy adult dose in elderly populations with Child–Pugh-A, Child–Pugh-B, and Child–Pugh-C hepatic impairment, respectively. Conclusion: The results suggest that the PBPK model of candesartan can be utilized to optimize dosage regimens for special populations.

show abstract

Section: Adult Pbpk Model Developmentmentioning

confidence: 99%